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Institution

Sapienza University of Rome

EducationRome, Lazio, Italy
About: Sapienza University of Rome is a education organization based out in Rome, Lazio, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 62002 authors who have published 155468 publications receiving 4397244 citations. The organization is also known as: La Sapienza & Università La Sapienza di Roma.


Papers
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Journal ArticleDOI
TL;DR: This article performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects, and genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 controls.
Abstract: We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 controls. Variants from 13 new regions reached genome-wide significance (P(combined) < 5 x 10(-8)); most contain genes with immune functions (BACH2, CCR4, CD80, CIITA-SOCS1-CLEC16A, ICOSLG and ZMIZ1), with ETS1, RUNX3, THEMIS and TNFRSF14 having key roles in thymic T-cell selection. There was evidence to suggest associations for a further 13 regions. In an expression quantitative trait meta-analysis of 1,469 whole blood samples, 20 of 38 (52.6%) tested loci had celiac risk variants correlated (P < 0.0028, FDR 5%) with cis gene expression.

894 citations

Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott1, T. D. Abbott2, Fausto Acernese3  +1319 moreInstitutions (78)
02 Nov 2017-Nature
TL;DR: A measurement of the Hubble constant is reported that combines the distance to the source inferred purely from the gravitational-wave signal with the recession velocity inferred from measurements of the redshift using the electromagnetic data.
Abstract: On 17 August 2017, the Advanced LIGO1 and Virgo2 detectors observed the gravitational-wave event GW170817—a strong signal from the merger of a binary neutron-star system3. Less than two seconds after the merger, a γ-ray burst (GRB 170817A) was detected within a region of the sky consistent with the LIGO–Virgo-derived location of the gravitational-wave source4, 5, 6. This sky region was subsequently observed by optical astronomy facilities7, resulting in the identification8, 9, 10, 11, 12, 13 of an optical transient signal within about ten arcseconds of the galaxy NGC 4993. This detection of GW170817 in both gravitational waves and electromagnetic waves represents the first ‘multi-messenger’ astronomical observation. Such observations enable GW170817 to be used as a ‘standard siren’14, 15, 16, 17, 18 (meaning that the absolute distance to the source can be determined directly from the gravitational-wave measurements) to measure the Hubble constant. This quantity represents the local expansion rate of the Universe, sets the overall scale of the Universe and is of fundamental importance to cosmology. Here we report a measurement of the Hubble constant that combines the distance to the source inferred purely from the gravitational-wave signal with the recession velocity inferred from measurements of the redshift using the electromagnetic data. In contrast to previous measurements, ours does not require the use of a cosmic ‘distance ladder’19: the gravitational-wave analysis can be used to estimate the luminosity distance out to cosmological scales directly, without the use of intermediate astronomical distance measurements. We determine the Hubble constant to be about 70 kilometres per second per megaparsec. This value is consistent with existing measurements20, 21, while being completely independent of them. Additional standard siren measurements from future gravitational-wave sources will enable the Hubble constant to be constrained to high precision.

892 citations

Journal ArticleDOI
TL;DR: A new paradigm for the design of transmitter space-time coding is introduced that is referred to as linear precoding, which leads to simple closed-form solutions for transmission over frequency-selective multiple-input multiple-output (MIMO) channels, which are scalable with respect to the number of antennas, size of the coding block, and transmit average/peak power.
Abstract: We introduce a new paradigm for the design of transmitter space-time coding that we refer to as linear precoding. It leads to simple closed-form solutions for transmission over frequency-selective multiple-input multiple-output (MIMO) channels, which are scalable with respect to the number of antennas, size of the coding block, and transmit average/peak power. The scheme operates as a block transmission system in which vectors of symbols are encoded and modulated through a linear mapping operating jointly in the space and time dimension. The specific designs target minimization of the symbol mean square error and the approximate maximization of the minimum distance between symbol hypotheses, under average and peak power constraints. The solutions are shown to convert the MIMO channel with memory into a set of parallel flat fading subchannels, regardless of the design criterion, while appropriate power/bits loading on the subchannels is the specific signature of the different designs. The proposed designs are compared in terms of various performance measures such as information rate, BER, and symbol mean square error.

891 citations

Journal ArticleDOI
TL;DR: A consensus scheme for diagnosing malnutrition in adults in clinical settings on a global scale is proposed and it is recommended that the etiologic criteria be used to guide intervention and anticipated outcomes.
Abstract: Summary Rationale This initiative is focused on building a global consensus around core diagnostic criteria for malnutrition in adults in clinical settings Methods In January 2016, the Global Leadership Initiative on Malnutrition (GLIM) was convened by several of the major global clinical nutrition societies GLIM appointed a core leadership committee and a supporting working group with representatives bringing additional global diversity and expertise Empirical consensus was reached through a series of face-to-face meetings, telephone conferences, and e-mail communications Results A two-step approach for the malnutrition diagnosis was selected, ie, first screening to identify “at risk” status by the use of any validated screening tool, and second, assessment for diagnosis and grading the severity of malnutrition The malnutrition criteria for consideration were retrieved from existing approaches for screening and assessment Potential criteria were subjected to a ballot among the GLIM core and supporting working group members The top five ranked criteria included three phenotypic criteria (non-volitional weight loss, low body mass index, and reduced muscle mass) and two etiologic criteria (reduced food intake or assimilation, and inflammation or disease burden) To diagnose malnutrition at least one phenotypic criterion and one etiologic criterion should be present Phenotypic metrics for grading severity as Stage 1 (moderate) and Stage 2 (severe) malnutrition are proposed It is recommended that the etiologic criteria be used to guide intervention and anticipated outcomes The recommended approach supports classification of malnutrition into four etiology-related diagnosis categories Conclusion A consensus scheme for diagnosing malnutrition in adults in clinical settings on a global scale is proposed Next steps are to secure further collaboration and endorsements from leading nutrition professional societies, to identify overlaps with syndromes like cachexia and sarcopenia, and to promote dissemination, validation studies, and feedback The diagnostic construct should be re-considered every 3–5 years

885 citations

Book ChapterDOI
TL;DR: This paper presents a new ontology language, based on Description Logics, that is particularly suited to reason with large amounts of instances and a novel mapping language that is able to deal with the so-called impedance mismatch problem.
Abstract: Many organizations nowadays face the problem of accessing existing data sources by means of flexible mechanisms that are both powerful and efficient. Ontologies are widely considered as a suitable formal tool for sophisticated data access. The ontology expresses the domain of interest of the information system at a high level of abstraction, and the relationship between data at the sources and instances of concepts and roles in the ontology is expressed by means of mappings. In this paper we present a solution to the problem of designing effective systems for ontology-based data access. Our solution is based on three main ingredients. First, we present a new ontology language, based on Description Logics, that is particularly suited to reason with large amounts of instances. The second ingredient is a novel mapping language that is able to deal with the so-called impedance mismatch problem, i.e., the problem arising from the difference between the basic elements managed by the sources, namely data, and the elements managed by the ontology, namely objects. The third ingredient is the query answering method, that combines reasoning at the level of the ontology with specific mechanisms for both taking into account the mappings and efficiently accessing the data at the sources.

884 citations


Authors

Showing all 62745 results

NameH-indexPapersCitations
Charles A. Dinarello1901058139668
Gregory Y.H. Lip1693159171742
Peter A. R. Ade1621387138051
H. Eugene Stanley1541190122321
Suvadeep Bose154960129071
P. de Bernardis152680117804
Bart Staels15282486638
Alessandro Melchiorri151674116384
Andrew H. Jaffe149518110033
F. Piacentini149531108493
Subir Sarkar1491542144614
Albert Bandura148255276143
Carlo Rovelli1461502103550
Robert C. Gallo14582568212
R. Kowalewski1431815135517
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023405
20221,106
20219,796
20209,753
20198,332
20187,615