Institution
Sapienza University of Rome
Education•Rome, Lazio, Italy•
About: Sapienza University of Rome is a education organization based out in Rome, Lazio, Italy. It is known for research contribution in the topics: Population & Medicine. The organization has 62002 authors who have published 155468 publications receiving 4397244 citations. The organization is also known as: La Sapienza & Università La Sapienza di Roma.
Topics: Population, Medicine, Context (language use), Cancer, Nonlinear system
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors used the ATLAS detector to detect dijet asymmetry in the collisions of lead ions at the Large Hadron Collider and found that the transverse energies of dijets in opposite hemispheres become systematically more unbalanced with increasing event centrality, leading to a large number of events which contain highly asymmetric di jets.
Abstract: By using the ATLAS detector, observations have been made of a centrality-dependent dijet asymmetry in the collisions of lead ions at the Large Hadron Collider. In a sample of lead-lead events with a per-nucleon center of mass energy of 2.76 TeV, selected with a minimum bias trigger, jets are reconstructed in fine-grained, longitudinally segmented electromagnetic and hadronic calorimeters. The transverse energies of dijets in opposite hemispheres are observed to become systematically more unbalanced with increasing event centrality leading to a large number of events which contain highly asymmetric dijets. This is the first observation of an enhancement of events with such large dijet asymmetries, not observed in proton-proton collisions, which may point to an interpretation in terms of strong jet energy loss in a hot, dense medium.
630 citations
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TL;DR: In this article, a model to account for the role of the ceramic fillers in enhancing the transport properties of PEO-based composite polymer electrolytes is proposed, supported by a series of specifically addressed electrochemical tests which included the determination of the conductivity and of the lithium transference number of various composite electrolyte samples differing from the type of the surface states of a ceramic filler.
630 citations
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Curie Institute1, Memorial Sloan Kettering Cancer Center2, University of Antwerp3, University of Düsseldorf4, European Institute of Oncology5, Hospital Clínico San Carlos6, Imperial College Healthcare7, University of Cambridge8, Sapienza University of Rome9, Autonomous University of Barcelona10, Université libre de Bruxelles11, Katholieke Universiteit Leuven12, University of Ulm13, Saarland University14, Université catholique de Louvain15, University of Hamburg16, Paris Descartes University17, University of Paris-Sud18
TL;DR: These data confirm the independent prognostic effect of CTC count on progression-free survival and overall survival and also improves the prognostication of metastatic breast cancer when added to full clinicopathological predictive models, whereas serum tumour markers do not.
Abstract: Summary Background We aimed to assess the clinical validity of circulating tumour cell (CTC) quantification for prognostication of patients with metastatic breast cancer by undertaking a pooled analysis of individual patient data. Methods We contacted 51 European centres and asked them to provide reported and unreported anonymised data for individual patients with metastatic breast cancer who participated in studies between January, 2003, and July, 2012. Eligible studies had participants starting a new line of therapy, data for progression-free survival or overall survival, or both, and CTC quantification by the CellSearch method at baseline (before start of new treatment). We used Cox regression models, stratified by study, to establish the association between CTC count and progression-free survival and overall survival. We used the landmark method to assess the prognostic value of CTC and serum marker changes during treatment. We assessed the added value of CTCs or serum markers to prognostic clinicopathological models in a resampling procedure using likelihood ratio (LR) χ 2 statistics. Findings 17 centres provided data for 1944 eligible patients from 20 studies. 911 patients (46·9%) had a CTC count of 5 per 7·5 mL or higher at baseline, which was associated with decreased progression-free survival (hazard ratio [HR] 1·92, 95% CI 1·73–2·14, p Interpretation These data confirm the independent prognostic effect of CTC count on progression-free survival and overall survival. CTC count also improves the prognostication of metastatic breast cancer when added to full clinicopathological predictive models, whereas serum tumour markers do not. Funding Janssen Diagnostics, the Nuovo-Soldati foundation for cancer research.
630 citations
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TL;DR: In this paper, the authors examined the possibility for hidden and open charm diquark-antidiquark states deducing spectra from constituent quark masses and spin-spin interactions, and showed that heavy light diquarks can be the building blocks of a rich spectrum of states which can accommodate some of the newly observed charmoniumlike resonances not fitting a pure $c\overline{c}$ assignment.
Abstract: Heavy-light diquarks can be the building blocks of a rich spectrum of states which can accommodate some of the newly observed charmoniumlike resonances not fitting a pure $c\overline{c}$ assignment. We examine this possibility for hidden and open charm diquark-antidiquark states deducing spectra from constituent quark masses and spin-spin interactions. Taking the $X(3872)$ as input we predict the existence of a ${2}^{++}$ state that can be associated to the $X(3940)$ observed by Belle and reexamine the state claimed by SELEX, $X(2632)$. The possible assignment of the previously discovered states ${D}_{s}(2317)$ and ${D}_{s}(2457)$ is discussed. We predict $X(3872)$ to be made of two components with a mass difference related to ${m}_{u}\ensuremath{-}{m}_{d}$ and discuss the production of $X(3872)$ and of its charged partner ${X}^{\ifmmode\pm\else\textpm\fi{}}$ in the weak decays of ${B}^{+,0}$.
629 citations
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TL;DR: Together with their spontaneous commitment to cardiac and angiogenic differentiation, transplanted CDCs serve as “role models,” recruiting endogenous regeneration and improving tissue resistance to ischemic stress.
Abstract: Rationale: Multiple biological mechanisms contribute to the efficacy of cardiac cell therapy. Most prominent among these are direct heart muscle and blood vessel regeneration from transplanted cells, as opposed to paracrine enhancement of tissue preservation and/or recruitment of endogenous repair. Objective: Human cardiac progenitor cells, cultured as cardiospheres (CSps) or as CSp-derived cells (CDCs), have been shown to be capable of direct cardiac regeneration in vivo. Here we characterized paracrine effects in CDC transplantation and investigated their relative importance versus direct differentiation of surviving transplanted cells. Methods and Results: In vitro, many growth factors were found in media conditioned by human adult CSps and CDCs; CDC-conditioned media exerted antiapoptotic effects on neonatal rat ventricular myocytes, and proangiogenic effects on human umbilical vein endothelial cells. In vivo, human CDCs secreted vascular endothelial growth factor, hepatocyte growth factor, and insuli...
628 citations
Authors
Showing all 62745 results
Name | H-index | Papers | Citations |
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Charles A. Dinarello | 190 | 1058 | 139668 |
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Peter A. R. Ade | 162 | 1387 | 138051 |
H. Eugene Stanley | 154 | 1190 | 122321 |
Suvadeep Bose | 154 | 960 | 129071 |
P. de Bernardis | 152 | 680 | 117804 |
Bart Staels | 152 | 824 | 86638 |
Alessandro Melchiorri | 151 | 674 | 116384 |
Andrew H. Jaffe | 149 | 518 | 110033 |
F. Piacentini | 149 | 531 | 108493 |
Subir Sarkar | 149 | 1542 | 144614 |
Albert Bandura | 148 | 255 | 276143 |
Carlo Rovelli | 146 | 1502 | 103550 |
Robert C. Gallo | 145 | 825 | 68212 |
R. Kowalewski | 143 | 1815 | 135517 |