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Institution

Saskatchewan Health

GovernmentRegina, Saskatchewan, Canada
About: Saskatchewan Health is a government organization based out in Regina, Saskatchewan, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 442 authors who have published 489 publications receiving 7728 citations.


Papers
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Journal ArticleDOI
TL;DR: Factors that influence WTSR of SFs are identified and indicates that HCPs make tradeoffs between patient preference and other outcome characteristics, which can inform clinical scenarios and models aiming to understand shared decision-making, patient and family opportunity to benefit, and cost-effectiveness.

6 citations

Journal ArticleDOI
TL;DR: Findings highlight the need for mandated GF folate food fortification policy among children with CD on the gluten-free diet and folate content of household food purchases.
Abstract: The lack of mandated folate enrichment of gluten-free (GF) grains in Canada has been suspected to contribute to suboptimal folate intake among children suffering from Celiac disease (CD). Children ...

6 citations

Journal ArticleDOI
TL;DR: Strategies to help improve home-based dialysis included improved education, local support, integrated traditional medicine, cultural sensitivity, and leadership prioritization.
Abstract: Background:Renal replacement options or dialysis can be delivered in the home setting or hospital setting. Home dialysis offers a number of benefits over hospital-delivered dialysis. These advantag...

6 citations

Journal ArticleDOI
TL;DR: The process and outcomes of creating and evaluating the feedback of research findings to healthcare aides and the importance of understanding organizational routines and the impact of corporate restructuring were key themes emerging from the case study.
Abstract: Background This report is an introduction to a series of three research papers that describe the evolution of the approaches taken by the Translating Research in Elder Care (TREC) research team during its first four years to feed back the research findings to study participants. TREC is an observational multi-method health services research project underway in 36 nursing homes in the prairie provinces of Canada. TREC has actively involved decision makers from the sector in all stages from initial planning, through data collection to dissemination activities. However, it was not planned as a fully integrated knowledge translation project. These three papers describe our progress towards fully integrated knowledge translation—with respect to timely and requested feedback processes. The first paper reports on the process and outcomes of creating and evaluating the feedback of research findings to healthcare aides (unregulated health professionals). These aides provide over 80% of the direct care in our sample and actively requested the feedback as a condition of their continued cooperation in the data acquisition process. The second paper describes feedback from nursing home administrators on preliminary research findings (a facility annual report) and evaluation of the reports’ utility. The third paper discusses an approach to providing a more in-depth form of feedback (expanded feedback report) at one of the TREC nursing homes.

6 citations

Journal ArticleDOI
01 Mar 2019
TL;DR: This retrospective data analysis demonstrated a clustering of variant T PMT genotypes with phenotypes, no significant influence of age and sex on TPMT activity, and an equal distribution of ITPA variants among various TPMt subgroups.
Abstract: Background: Therapeutic efficacy and toxicity of thiopurine drugs (used as anticancer and immunosuppressant agents) are affected by thiopurine S-methyltransferase (TPMT) enzyme activity. TPMT genotype and/or phenotype is used to predict the risk for adverse effects before drug administration. Inosine triphosphate pyrophosphatase (ITPA) is another enzyme involved in thiopurine metabolism. In this study, we aimed to evaluate (a) frequency of various TPMT phenotypes and genotypes, (b) correlations between them, (c) influence of age and sex on TPMT activity, and (d) distribution of ITPA variants among various TPMT subgroups. Methods: TPMT enzyme activity was determined by LC-MS/MS. TPMT (*2,*3A–C) and ITPA (rs1127354, rs7270101) genotypes were determined using a customized TaqMan® OpenArray®. Results: TPMT enzyme activity varied largely (6.3–90 U/mL). The frequency of low, intermediate, normal, and high activity was 0.5% (n = 230), 13.1% (n = 5998), 86.1% (n = 39448), and 0.28% (n = 126), respectively. No significant difference in TPMT activity in relation to age and sex was found. Genotype analysis revealed the frequency of variant TPMT alleles was 6.73% (*3A, n = 344), 0.05% (*3B, n = 2), 2.22% (*3C, n = 95), and 0.42% (*2, n = 19). Analysis of paired phenotype and genotype showed that TPMT activity in samples with variant allele(s) was significantly lower than those without variant alleles. Lastly, an equal distribution of ITPA variants was found among normal and abnormal TPMT activity. Conclusions: This retrospective data analysis demonstrated a clustering of variant TPMT genotypes with phenotypes, no significant influence of age and sex on TPMT activity, and an equal distribution of ITPA variants among various TPMT subgroups.

6 citations


Authors

Showing all 449 results

NameH-indexPapersCitations
Gary R. Hunter7133716410
Lisa M. Lix5946213778
Peter O'Hare551269246
Edward D. Chan542249014
Paul Babyn5430711466
Roland N. Auer521208564
Paul N. Levett441378486
Alan A. Boulton391835253
Carl D'Arcy381295002
Vikram Misra371164363
Andrew W. Lyon281092449
Denis C. Lehotay27521756
Gary F. Teare26612749
Greg B. Horsman25491727
Emina Torlakovic24961899
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20232
20221
2021116
202088
201959
201836