Institution
Saskatchewan Health
Government•Regina, Saskatchewan, Canada•
About: Saskatchewan Health is a government organization based out in Regina, Saskatchewan, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 442 authors who have published 489 publications receiving 7728 citations.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Investigating a possible association between statin use and breast cancer (BRCA) in eligible women from 1989 to mid-1997 and an age-sex-matched nonexposed group were followed up to 8.5 years revealed increases in risk in short-term statinusers and statin users with long-term hormone replacement therapy (HRT) exposure.
93 citations
••
TL;DR: Analytical sensitivities were equivalent between LDTs and most commercially available methods, and some commercially available real-time RT-PCR assays.
92 citations
••
TL;DR: The CCRS provides a robust, high quality data source that may be used to inform policy, clinical practice and service delivery in Ontario and they provide a benchmark for comparisons with other jurisdictions implementing the RAI 2.0 in similar populations.
Abstract: Evidence informed decision making in health policy development and clinical practice depends on the availability of valid and reliable data. The introduction of interRAI assessment systems in many countries has provided valuable new information that can be used to support case mix based payment systems, quality monitoring, outcome measurement and care planning. The Continuing Care Reporting System (CCRS) managed by the Canadian Institute for Health Information has served as a data repository supporting national implementation of the Resident Assessment Instrument (RAI 2.0) in Canada for more than 15 years. The present paper aims to evaluate data quality for the CCRS using an approach that may be generalizable to comparable data holdings internationally. Data from the RAI 2.0 implementation in Complex Continuing Care (CCC) hospitals/units and Long Term Care (LTC) homes in Ontario were analyzed using various statistical techniques that provide evidence for trends in validity, reliability, and population attributes. Time series comparisons included evaluations of scale reliability, patterns of associations between items and scales that provide evidence about convergent validity, and measures of changes in population characteristics over time. Data quality with respect to reliability, validity, completeness and freedom from logical coding errors was consistently high for the CCRS in both CCC and LTC settings. The addition of logic checks further improved data quality in both settings. The only notable change of concern was a substantial inflation in the percentage of long term care home residents qualifying for the Special Rehabilitation level of the Resource Utilization Groups (RUG-III) case mix system after the adoption of that system as part of the payment system for LTC. The CCRS provides a robust, high quality data source that may be used to inform policy, clinical practice and service delivery in Ontario. Only one area of concern was noted, and the statistical techniques employed here may be readily used to target organizations with data quality problems in that (or any other) area. There was also evidence that data quality was good in both CCC and LTC settings from the outset of implementation, meaning data may be used from the entire time series. The methods employed here may continue to be used to monitor data quality in this province over time and they provide a benchmark for comparisons with other jurisdictions implementing the RAI 2.0 in similar populations.
82 citations
••
McGill University1, Jewish General Hospital2, McGill University Health Centre3, McMaster University4, University of Manitoba5, University of British Columbia6, University of Western Ontario7, Université de Montréal8, Saskatchewan Health9, York University10, University of Toronto11, University of Calgary12
TL;DR: Use of incretin-based drugs was not associated with an increased risk of acute pancreatitis compared with other oral antidiabetic drugs and there was no evidence of a duration-response association.
Abstract: Importance The association between incretin-based drugs, such as dipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide 1 (GLP-1) agonists, and acute pancreatitis is controversial. Objective To determine whether the use of incretin-based drugs, compared with the use of 2 or more other oral antidiabetic drugs, is associated with an increased risk of acute pancreatitis. Design, Setting, and Participants A large, international, multicenter, population-based cohort study was conducted using combined health records from 7 participating sites in Canada, the United States, and the United Kingdom. An overall cohort of 1 532 513 patients with type 2 diabetes initiating the use of antidiabetic drugs between January 1, 2007, and June 30, 2013, was included, with follow-up until June 30, 2014. Exposures Current use of incretin-based drugs compared with current use of at least 2 oral antidiabetic drugs. Main Outcomes and Measures Nested case-control analyses were conducted including hospitalized patients with acute pancreatitis matched with up to 20 controls on sex, age, cohort entry date, duration of treated diabetes, and follow-up duration. Hazard ratios (HRs) and 95% CIs for hospitalized acute pancreatitis were estimated and compared current use of incretin-based drugs with current use of 2 or more oral antidiabetic drugs. Secondary analyses were performed to assess whether the risk varied by class of drug (DPP-4 inhibitors and GLP-1 agonists) or by duration of use. Site-specific HRs were pooled using random-effects models. Results Of 1 532 513 patients included in the analysis, 781 567 (51.0%) were male; mean age was 56.6 years. During 3 464 659 person-years of follow-up, 5165 patients were hospitalized for acute pancreatitis (incidence rate, 1.49 per 1000 person-years). Compared with current use of 2 or more oral antidiabetic drugs, current use of incretin-based drugs was not associated with an increased risk of acute pancreatitis (pooled adjusted HR, 1.03; 95% CI, 0.87-1.22). Similarly, the risk did not vary by drug class (DPP-4 inhibitors: pooled adjusted HR, 1.09; 95% CI, 0.86-1.22; GLP-1 agonists: pooled adjusted HR, 1.04; 95% CI, 0.81-1.35) and there was no evidence of a duration-response association. Conclusions and Relevance In this large population-based study, use of incretin-based drugs was not associated with an increased risk of acute pancreatitis compared with other oral antidiabetic drugs.
81 citations
••
University of Ottawa1, Population Health Research Institute2, Laval University3, Halifax4, University of Western Ontario5, University of Toronto6, Université de Montréal7, Chinook Regional Hospital8, McGill University9, Libin Cardiovascular Institute of Alberta10, Queen's University11, Horizon Health Network12, Montreal Heart Institute13, Sunnybrook Health Sciences Centre14, University of British Columbia15, Royal Columbian Hospital16, Saskatchewan Health17, Centre Hospitalier Universitaire de Sherbrooke18, Radboud University Nijmegen19
TL;DR: This study identified 5 independent predictors of device infection and developed a novel infection risk score in the largest cardiac implantable electronic device trial to date, warranting validation in an independent cohort.
78 citations
Authors
Showing all 449 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gary R. Hunter | 71 | 337 | 16410 |
Lisa M. Lix | 59 | 462 | 13778 |
Peter O'Hare | 55 | 126 | 9246 |
Edward D. Chan | 54 | 224 | 9014 |
Paul Babyn | 54 | 307 | 11466 |
Roland N. Auer | 52 | 120 | 8564 |
Paul N. Levett | 44 | 137 | 8486 |
Alan A. Boulton | 39 | 183 | 5253 |
Carl D'Arcy | 38 | 129 | 5002 |
Vikram Misra | 37 | 116 | 4363 |
Andrew W. Lyon | 28 | 109 | 2449 |
Denis C. Lehotay | 27 | 52 | 1756 |
Gary F. Teare | 26 | 61 | 2749 |
Greg B. Horsman | 25 | 49 | 1727 |
Emina Torlakovic | 24 | 96 | 1899 |