Institution
Saudi Aramco
Company•Houston, Texas, United States•
About: Saudi Aramco is a company organization based out in Houston, Texas, United States. It is known for research contribution in the topics: Carbonate & Catalysis. The organization has 7107 authors who have published 9227 publications receiving 84639 citations. The organization is also known as: Aramco & Arabian-American Oil Company.
Topics: Carbonate, Catalysis, Drilling fluid, Hydraulic fracturing, Combustion
Papers published on a yearly basis
Papers
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TL;DR: Disease caused by MERS-CoV presents with a wide range of clinical manifestations and is associated with substantial mortality in admitted patients who have medical comorbidities, and major gaps in knowledge of the epidemiology, community prevalence, and clinical spectrum of infection and disease need urgent definition.
Abstract: Summary Background Middle East respiratory syndrome (MERS) is a new human disease caused by a novel coronavirus (CoV). Clinical data on MERS-CoV infections are scarce. We report epidemiological, demographic, clinical, and laboratory characteristics of 47 cases of MERS-CoV infections, identify knowledge gaps, and define research priorities. Methods We abstracted and analysed epidemiological, demographic, clinical, and laboratory data from confirmed cases of sporadic, household, community, and health-care-associated MERS-CoV infections reported from Saudi Arabia between Sept 1, 2012, and June 15, 2013. Cases were confirmed as having MERS-CoV by real-time RT-PCR. Findings 47 individuals (46 adults, one child) with laboratory-confirmed MERS-CoV disease were identified; 36 (77%) were male (male:female ratio 3·3:1). 28 patients died, a 60% case-fatality rate. The case-fatality rate rose with increasing age. Only two of the 47 cases were previously healthy; most patients (45 [96%]) had underlying comorbid medical disorders, including diabetes (32 [68%]), hypertension (16 [34%]), chronic cardiac disease (13 [28%]), and chronic renal disease (23 [49%]). Common symptoms at presentation were fever (46 [98%]), fever with chills or rigors (41 [87%]), cough (39 [83%]), shortness of breath (34 [72%]), and myalgia (15 [32%]). Gastrointestinal symptoms were also frequent, including diarrhoea (12 [26%]), vomiting (ten [21%]), and abdominal pain (eight [17%]). All patients had abnormal findings on chest radiography, ranging from subtle to extensive unilateral and bilateral abnormalities. Laboratory analyses showed raised concentrations of lactate dehydrogenase (23 [49%]) and aspartate aminotransferase (seven [15%]) and thrombocytopenia (17 [36%]) and lymphopenia (16 [34%]). Interpretation Disease caused by MERS-CoV presents with a wide range of clinical manifestations and is associated with substantial mortality in admitted patients who have medical comorbidities. Major gaps in our knowledge of the epidemiology, community prevalence, and clinical spectrum of infection and disease need urgent definition. Funding None.
1,275 citations
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TL;DR: In this paper, a detailed chemical kinetic mechanism has been developed to describe the oxidation of small hydrocarbon and oxygenated hydrocarbon species, such as formaldehyde, methanol, acetaldehyde, and ethanol.
Abstract: A detailed chemical kinetic mechanism has been developed to describe the oxidation of small hydrocarbon and oxygenated hydrocarbon species. The reactivity of these small fuels and intermediates is of critical importance in understanding and accurately describing the combustion characteristics, such as ignition delay time, flame speed, and emissions of practical fuels. The chosen rate expressions have been assembled through critical evaluation of the literature, with minimum optimization performed. The mechanism has been validated over a wide range of initial conditions and experimental devices, including flow reactor, shock tube, jet-stirred reactor, and flame studies. The current mechanism contains accurate kinetic descriptions for saturated and unsaturated hydrocarbons, namely methane, ethane, ethylene, and acetylene, and oxygenated species; formaldehyde, methanol, acetaldehyde, and ethanol.
925 citations
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TL;DR: Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene, a regulator of insulin secretion, mapped to 11p15.1 by means of fluorescence in situ hybridization.
Abstract: Familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion, is linked to chromosome 11p14-15.1. The newly cloned high-affinity sulfonylurea receptor (SUR) gene, a regulator of insulin secretion, was mapped to 11p15.1 by means of fluorescence in situ hybridization. Two separate SUR gene splice site mutations, which segregated with disease phenotype, were identified in affected individuals from nine different families. Both mutations resulted in aberrant processing of the RNA sequence and disruption of the putative second nucleotide binding domain of the SUR protein. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene.
781 citations
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580 citations
Authors
Showing all 7123 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hannes Jung | 159 | 2069 | 125069 |
Ian F. Akyildiz | 117 | 612 | 99653 |
Robert Turner | 111 | 557 | 58744 |
Praveen Kumar | 88 | 1339 | 35718 |
Yu Han | 84 | 429 | 28745 |
Amos Nur | 79 | 314 | 23560 |
Dimitris C. Lagoudas | 67 | 501 | 18356 |
Yousung Jung | 60 | 212 | 17452 |
Richard W. Baker | 58 | 246 | 23289 |
Wei Wang | 58 | 774 | 15085 |
Gautam Kalghatgi | 50 | 117 | 7841 |
Valentin N. Parmon | 49 | 703 | 11514 |
M. A. Abido | 49 | 292 | 12124 |
Jack Dvorkin | 48 | 290 | 14908 |
Gary Mavko | 47 | 286 | 11799 |