Institution
Schering-Plough
About: Schering-Plough is a based out in . It is known for research contribution in the topics: Receptor & Cytokine. The organization has 7637 authors who have published 8799 publications receiving 469191 citations.
Topics: Receptor, Cytokine, Alkyl, Immune system, T cell
Papers published on a yearly basis
Papers
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TL;DR: The revised RECIST includes a new imaging appendix with updated recommendations on the optimal anatomical assessment of lesions, and a section on detection of new lesions, including the interpretation of FDG-PET scan assessment is included.
20,760 citations
TL;DR: Losartan conferred significant renal benefits in patients with type 2 diabetes and nephropathy, and it was generally well tolerated.
Abstract: Background Diabetic nephropathy is the leading cause of end-stage renal disease. Interruption of the renin–angiotensin system slows the progression of renal disease in patients with type 1 diabetes, but similar data are not available for patients with type 2, the most common form of diabetes. We assessed the role of the angiotensin-II–receptor antagonist losartan in patients with type 2 diabetes and nephropathy. Methods A total of 1513 patients were enrolled in this randomized, double-blind study comparing losartan (50 to 100 mg once daily) with placebo, both taken in addition to conventional antihypertensive treatment (calcium-channel antagonists, diuretics, alpha-blockers, beta-blockers, and centrally acting agents), for a mean of 3.4 years. The primary outcome was the composite of a doubling of the base-line serum creatinine concentration, end-stage renal disease, or death. Secondary end points included a composite of morbidity and mortality from cardiovascular causes, proteinuria, and the rate of prog...
6,547 citations
TL;DR: In patients with chronic hepatitis C, the most effective therapy is the combination of peginterferon alfa-2b 1.5 microg/kg per week plus ribavirin, and this randomised trial found that the benefit is mostly achieved in patients with HCV genotype 1 infections.
6,228 citations
TL;DR: It is shown that the orphan nuclear receptor RORgammat is the key transcription factor that orchestrates the differentiation of this effector cell lineage of proinflammatory T helper cells and its potential as a therapeutic target in inflammatory diseases is highlighted.
4,616 citations
TL;DR: The pharmaceutical industry faces considerable challenges, both politically and fiscally, and the fiscal pressures that face the industry from the perspective of R&D are dealt with.
Abstract: The pharmaceutical industry faces considerable challenges, both politically and fiscally. Politically, governments around the world are trying to contain costs and, as health care budgets constitute a very significant part of governmental spending, these costs are the subject of intense scrutiny. In the United States, drug costs are also the subject of intense political discourse. This article deals with the fiscal pressures that face the industry from the perspective of R&D. What impinges on productivity? How can we improve current reduced R&D productivity?
3,746 citations
Authors
Showing all 7637 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Lewis L. Lanier | 159 | 554 | 86677 |
| Eugene C. Butcher | 146 | 446 | 72849 |
| Jacques Banchereau | 143 | 634 | 99261 |
| Joseph Lau | 140 | 1048 | 99305 |
| Giorgio Trinchieri | 138 | 433 | 78028 |
| Victor J. Dzau | 130 | 688 | 66047 |
| George Q. Daley | 127 | 490 | 75000 |
| Jay H. Hoofnagle | 121 | 434 | 57008 |
| Elliott Kieff | 118 | 346 | 42541 |
| John J. Fung | 115 | 1011 | 52924 |
| Lee M. Nadler | 109 | 412 | 41367 |
| Gerald J. Gleich | 108 | 606 | 46698 |
| Jean-Yves Blay | 104 | 808 | 45637 |
| Henry N. Ginsberg | 104 | 413 | 51009 |
| Anne O'Garra | 100 | 235 | 59951 |