Shahid Beheshti University of Medical Sciences and Health Services

About: Shahid Beheshti University of Medical Sciences and Health Services is a education organization based out in Tehran, Iran. It is known for research contribution in the topics: Population & Cancer. The organization has 19456 authors who have published 33659 publications receiving 365676 citations.

Reliability and Validity of the Persian Version of the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS)

Abstract: Objectives: The aim was to evaluate the validity and reliability of the persian version of Yale-Brown Obsessive- Compulsive Scale (Y-BOCS). Method: The sum of 140 patients with obsessive-compulsive disorder (OCD) and 30 individual participants without OCD were selected via convenient sampling as experimental and control groups respectively. Data gathering was done using Y-BOCS, Structured Clinical Interview for DSM-IV axis-I disorders (SCID-I) and Symptom Checklist-90-Revised Obsessive- Compulsive Symptoms (SCL-90-R-OCS). Reliability coefficients were calculated by Cronbach's alpha, split-half, and test- retest reliability. For validity assessment, concurrent criterion-related validity in correlation with SCID-I and SCL-90-R-OCS, and construct validity (exploratory factor analysis) were executed. In order to normalize the Y- BOCS after insuring that the distribution is normal and does not have kurtosis and skewness, mean and standard deviation were used as the most appropriate central tendencies and deviation. Results: Optimal levels of internal consistency scores (symptom checklist 0.97, severity scale 0.95) split-half reliability (symptom checklist 0.93, severity scale 0.89), and test-retest reliability (0.99) were calculated. Concurrent reliability were examined and established by correlating the Y-BOCS with the SCL-90-R-OCS and SCID-I. Exploratory factor analysis was also examined, which indicated three factors for symptom checklist scale and two factors for symptom severity scale. Cutoff point value (9) was also determined. Conclusion: The results supported satisfactory validity and reliability of translated form of Yale-brown Obsessive-Compulsive Scale for research and clinical diagnostic applications.

Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial

Abstract: In vitro and animal studies have reported that young broccoli sprouts improve oxidative stress status in diabetic condition. The objective of this double-blind, placebo-controlled, randomized clinical trial was to investigate the effects of broccoli sprouts powder (BSP) on some oxidative stress parameters in type 2 diabetes patients. A total of 81 patients with type 2 diabetes were randomly assigned to one of three treatment groups for 4 weeks. The groups received either 10 g/d BSP (n=27), 5 g/d BSP (n=29) or placebo (n=25). Serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and oxidized low density lipoprotein (LDL) cholesterol were measured at baseline and at 4 weeks after treatment. In all, 63 patients in three groups were included in the analysis: 10 g/d BSP (n=21), 5 g/d (n=22) and placebo (n=20). After 4 weeks, consumption of BSP resulted in significant decrease in MDA (P=0.001 for treatment effect), oxidized low density lipoprotein cholesterol (P=0.03 for treatment effect), OSI (P=0.001 for treatment effect) and significant increase in TAC (P=0.001 for treatment effect). No effects were found on TOS. BSP had favorable effects on oxidative stress status in type 2 diabetes patients.

Lipid ratios and appropriate cut off values for prediction of diabetes: a cohort of Iranian men and women

Abstract: Background Dyslipidemia is a risk factor for incident type 2 diabetes; however, no study has specifically assessed the lipid ratios (i.e. total cholesterol (TC)/high density lipoprotein cholesterol (HDL-C) and triglyceride (TG)/HDL-C) as predictors of diabetes. We aimed to compare the independent association between the different lipid measures with incident diabetes over a median follow up of 6.4 years in Iranian men and women.