scispace - formally typeset
Search or ask a question
Institution

Shahid Beheshti University of Medical Sciences and Health Services

EducationTehran, Iran
About: Shahid Beheshti University of Medical Sciences and Health Services is a education organization based out in Tehran, Iran. It is known for research contribution in the topics: Population & Cancer. The organization has 19456 authors who have published 33659 publications receiving 365676 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: Analysis of high-resolution structures of linezolid has demonstrated that it binds a deep cleft of the 50S ribosomal subunit that is surrounded by 23S rRNA nucleotides, which is considered as a useful antibiotic to treat infections in the ICU.
Abstract: Linezolid can be considered as the first member of the class of oxazolidinone antibiotics. The compound is a synthetic antibiotic that inhibits bacterial protein synthesis through binding to rRNA. It also inhibits the creation of the initiation complex during protein synthesis which can reduce the length of the developed peptide chains, and decrease the rate of reaction of translation elongation. Linezolid has been approved for the treatment of infections caused by vancomycin-resistant Enterococcus faecium, hospital-acquired pneumonia caused by Staphylococcus aureus, complicated skin and skin structure infections (SSSIs), uncomplicated SSSIs caused by methicillin-susceptible S. aureus or Streptococcus pyogenes, and community-acquired pneumonia caused by Streptococcus pneumoniae. Analysis of high-resolution structures of linezolid has demonstrated that it binds a deep cleft of the 50S ribosomal subunit that is surrounded by 23S rRNA nucleotides. Mutation of 23S rRNA was shown to be a linezolid resistance mechanism. Besides, mutations in specific regions of ribosomal proteins uL3 and uL4 are increasingly associated with linezolid resistance. However, these proteins are located further away from the bound drug. The methicillin-resistant S. aureus and vancomycin-resistant enterococci are considered the most common Gram-positive bacteria found in intensive care units (ICUs), and linezolid, as an antimicrobial drug, is commonly utilized to treat infected ICU patients. The drug has favorable in vitro and in vivo activity against the mentioned organisms and is considered as a useful antibiotic to treat infections in the ICU.

189 citations

Journal ArticleDOI
TL;DR: Although Ramadan fasting is safe for all healthy individuals, those with various diseases should consult their physicians and follow scientific recommendations.
Abstract: Background: Muslims fast from sunrise to sunset during the month of Ramadan, the 9th lunar month. The duration of fasting varies from 13 to 18 h/day. Fasting includes avoidance of d

187 citations

Journal ArticleDOI
TL;DR: RA content in different species of Labiatae was 0.0-58.5 mg g-1 of dried plants and the highest amount of RA was found in Mentha species especially M. spicata, which can be considered as a new source of rosmarinic acid.
Abstract: Background: Plants of Labiatae are used in traditional medicine and phytotherapy. Rosmarinic acid (RA) is a phenolic compound which is found in many genus of Labiatae and exhibits important biological activities. Materials and Methods: In this investigation, RA contents of 29 species of Labiatae named Salvia officinalis, Salvia limbata, Salvia virgata, Salvia hypoleuca, Salvia macrosiphon, Salvia choloroleuca, Melissa officinalis, Origanum vulgare, Lavandula angustifolia, Rosmarinus officinalis, Thymus daenensis, Thymus citriodorous, Thymus pubescens, Thymus vulgaris, Zataria multiflora, Mentha piperita, Mentha pulegium, Mentha longifolia, Mentha spicata, Mentha aquatica, Mentha crispa, Perovskia artemisoides, Zhumeria majdae, Satureja hortensis, Satureja khuzistanica, Satureja bachtiarica, Satureja atropatana, Satureja mutica and Satureja macrantha were determined by using high-performance liquid chromatographic method. Results: The results showed that RA content in different species of Labiatae was 0.0-58.5 mg g -1 of dried plants. The highest amount of RA was found in Mentha species especially M. spicata. Conclusion: M. spicata can be considered as a new source of rosmarinic acid .

185 citations

Journal ArticleDOI
TL;DR: Use of metformin is more effective in reducing oxidative stress compared with lifestyle modification alone and in cases, after three months treatment, there was a significant reduction in AOPP.

185 citations

Journal ArticleDOI
TL;DR: The eastern Mediterranean region is going through a crucial health phase, and the Arab uprisings and the wars that followed, coupled with ageing and population growth, will have a major impact on the region's health and resources.

184 citations


Authors

Showing all 19557 results

NameH-indexPapersCitations
Paul F. Jacques11444654507
Mohammad Abdollahi90104535531
Fereidoun Azizi80127941755
Roya Kelishadi7385333681
Nima Rezaei72121526295
Neal D. Freedman6832716908
Jamie E Craig6838015956
Amir Hossein Mahvi6368615816
Adriano G. Cruz6134612832
Ali Montazeri6162517494
Parvin Mirmiran5663715420
Harry A. Lando532429432
Fatemeh Atyabi533109985
Daniel Granato532359406
Pejman Rohani5219213386
Network Information
Related Institutions (5)
Tehran University of Medical Sciences
57.2K papers, 878.5K citations

98% related

Shiraz University of Medical Sciences
21K papers, 247.5K citations

97% related

Mashhad University of Medical Sciences
18.7K papers, 252.5K citations

96% related

Isfahan University of Medical Sciences
19.5K papers, 248.6K citations

94% related

Tarbiat Modares University
32.6K papers, 526.3K citations

88% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202332
2022187
20214,346
20204,415
20193,809
20183,480