Shahid Beheshti University of Medical Sciences and Health Services

About: Shahid Beheshti University of Medical Sciences and Health Services is a education organization based out in Tehran, Iran. It is known for research contribution in the topics: Population & Cancer. The organization has 19456 authors who have published 33659 publications receiving 365676 citations.

The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action.

Abstract: Anthocyanins are natural phenolic pigments with biological activity. They are well-known to have potent antioxidant and antiinflammatory activity, which explains the various biological effects reported for these substances suggesting their antidiabetic and anticancer activities, and their role in cardiovascular and neuroprotective prevention. This review aims to comprehensively analyze different studies performed on this class of compounds, their bioavailability and their therapeutic potential. An in-depth look in preclinical, in vitro and in vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, antiobesity as well as their antidiabetes and anticancer effects.

Antimicrobial activity of calcium hydroxide in endodontics: a review.

Abstract: The purpose of endodontic therapy is to preserve the patient's natural teeth without compromising the patient's local or systemic health. Calcium hydroxide has been included in several materials and antimicrobial formulations that are used in several treatment modalities in endodontics, such as inter-appointment intracanal medicaments. The purpose of this article was to review the antimicrobial properties of calcium hydroxide in endodontics. Calcium hydroxide has a high pH (approximately 12.5-12.8) and is classified chemically as a strong base. The lethal effects of calcium hydroxide on bacterial cells are probably due to protein denaturation and damage to DNA and cytoplasmic membranes. Calcium hydroxide has a wide range of antimicrobial activity against common endodontic pathogens but is less effective against Enterococcus faecalis and Candida albicans. Calcium hydroxide is also a valuable anti-endotoxin agent. However, its effect on microbial biofilms is controversial.

N,S co-doped TiO2 nanoparticles and nanosheets in simulated solar light for photocatalytic degradation of non-steroidal anti-inflammatory drugs in water: a comparative study

Abstract: Background In this study, highly visible-light photoactive nitrogen and sulfur co-doped TiO2 (N,S-TiO2) nanoparticles and nanosheets were synthesized via facile sol–gel and hydrothermal methods, respectively. The photocatalytic activities of N,S-TiO2 catalysts were evaluated by degradation of non-steroidal anti-inflammatory drugs, ibuprofen (IBP) and naproxen (NPX), under simulated solar irradiation. Results The N,S-TiO2 nanoparticle is a well-developed mesoporous structure that contains both anatase and rutile phases and a large BET surface area (132 m2 g−1). N,S-TiO2 nanosheets contain a complete anatase phase with a larger mesoporous structure and a smaller BET surface area (64 m2 g−1). The results showed that at catalyst loading of 2.0 g L−1 and pH 6, N,S-TiO2 nanoparticles can degrade 85% and 99.3% of IBP and NPX. At the same conditions, 71.6% of IBP and 99.1% of NPX were degraded by N,S-TiO2 nanosheets in this study. Conclusion The high photocatalytic activity of N,S-TiO2 may be due to synergistic effects of nitrogen and sulfur co-doping into TiO2, resulting in better separation of photogenerated electrons and holes and higher-visible light adsorption. Reusability tests of N,S-TiO2 showed that it could retain its catalytic activity even after six cycles. © 2015 Society of Chemical Industry