scispace - formally typeset
Search or ask a question
Institution

Shahid Beheshti University of Medical Sciences and Health Services

EducationTehran, Iran
About: Shahid Beheshti University of Medical Sciences and Health Services is a education organization based out in Tehran, Iran. It is known for research contribution in the topics: Population & Cancer. The organization has 19456 authors who have published 33659 publications receiving 365676 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: The findings of this study clearly demonstrate that hesperidin-mediated proapoptotic and antiproliferative actions are regulated via both PPARγ-dependent and PParγ-independent pathways in NALM-6 cells.
Abstract: Background Hesperidin, a flavanone present in citrus fruits, has been identified as a potent anticancer agent because of its proapoptotic and antiproliferative characteristics in some tumor cells. However, the precise mechanisms of action are not entirely understood.

105 citations

Journal ArticleDOI
TL;DR: In this paper, the activation of peroxymonosulfate (PMS) was investigated by activated carbon (AC) along with UV for 2,4,6-trichlorophenol (TCP) degradation.
Abstract: In this study, the activation of peroxymonosulfate (PMS) was investigated by activated carbon (AC) along with UV for 2,4,6-trichlorophenol (TCP) degradation. The effects of operating parameters including pH, PMS concentration, AC dosage, initial TCP concentration and reaction time on TCP degradation were studied and optimized at pH 5.0, 8.0 mM PMS, 0.75 g/L AC and 75 min. Single step or two step additions of PMS made no marked difference in terms of TCP removal. The results of PMS decomposition showed that, AC/UV configuration was able to significantly activate PMS to degrade TCP compared to sole application of AC or UV. The contribution of UV in activation of PMS was more than that of AC. The rate constants of TCP degradation were in range of 0.0103–0.0512 min −1 for initial TCP concentrations of 5–50 mg/L. Scavenging experiments revealed that sulfate radical was the dominant radical of its kind for degradation of TCP, although hydroxyl radical was also partly effective. The results indicated that contribution of free radicals in solution was higher than that of surface-bound radicals. Moreover, mineralization of TCP was evaluated by COD, TOC and chlorine release and related results were 50.2%, 31.2% and 55%, respectively.

105 citations

Journal ArticleDOI
TL;DR: Some natural products with potential neuroprotective properties against Aβ with respect to their mechanism of action are discussed, which could offer an addition to conventional medicine.
Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disorder to date, with no curative or preventive therapy. Histopathological hallmarks of AD include deposition of β-amyloid plaques and formation of neurofibrillary tangles. Extent studies on pathology of the disease have made important discoveries regarding mechanism of disease and potential therapeutic targets. Many cellular changes including oxidative stress, disruption of Ca2+ homeostasis, inflammation, metabolic disturbances, and accumulation of unfolded/misfolded proteins can lead to programmed cell death in AD. Despite intensive research, only five approved drugs are available for the management of AD. Hence, there is a need to look at alternative therapies. Use of natural products and culinary herbs in medicine has gained popularity in recent years. Several natural substances with neuroprotective effects have been widely studied. Most of these compounds have remarkable antioxidant properties and act mainly by scavenging free radical species. Some of them increase cell survival and improve cognition by directly affecting amyloidogenesis and programmed cell death pathways. Further studies on these natural products and their mechanism of action, parallel with the use of novel pharmaceutical drug design and delivery techniques, enable us to offer an addition to conventional medicine. This review discussed some natural products with potential neuroprotective properties against Aβ with respect to their mechanism of action.

105 citations

Journal Article
TL;DR: The identified prognostic factors imply a relatively comprehensive understanding of factors related to survival rate in OSCC patients, and provide an additional tool for selecting patients who need more aggressive treatment design.
Abstract: Oral squamous cell carcinoma (OSCC) represents 95% of all forms of head and neck cancers. The five-year survival rate of OSCC patients has been reported approximately 50%, which is not satisfactory despite new treatment modalities. The aim of the current review is to present factors (histologic, clinical, genetic and molecular biomarkers) correlated with survival rate in OSCC patients. A web-based search for all types of articles published was initiated using MEDLINE/PubMed. The search was restricted to articles focusing on relevant clinical, histologic, genetic and molecular factors of survival rate in OSCC and presenting new concepts in this field. Mode of invasion, presence of lymph node metastasis, extra-capsular spread, surgical margins and invasive tumor front grade are clinical and histologic parameters, which are strongly associated with survival rate. Focusing on selected proteins, wide range of molecular markers and gene alterations involving in cell cycle regulation, apoptosis, cell migration, cell adhesion and tumor microenvironment have been documented. Among well-known molecular markers, cyclin dependent kinase, survivin, CD44, BUBR1, and heat shock proteins (27,70) can be considered as independent prognostic factors of survival rate. The identified prognostic factors imply a relatively comprehensive understanding of factors related to survival rate in OSCC patients, and provide an additional tool for selecting patients who need more aggressive treatment design.

105 citations

Journal ArticleDOI
TL;DR: Excellent treatment outcomes occurred in molar teeth with irreversible pulpitis undergoing pulpotomy with MTA and CEM biomaterials as well as clinical and radiographic outcomes of treatment.
Abstract: Objective To conduct a randomized clinical trial to compare the post-operative pain experience as well as clinical and radiographic outcomes of pulpotomy in human permanent molars with irreversible pulpitis using calcium enriched mixture (CEM) cement or mineral trioxide aggregate (MTA) Materials and mcethods A total of 413 patients met the inclusion criteria and consented to participate The patients were randomly allocated into two study arms: MTA pulpotomy (PMTA: n = 208) and CEM pulpotomy (PCEM: n = 205) Numerical rating scale questionnaires were utilized by the patients to record pain intensity (PI) over 7 days post-operatively The patients were followed-up for 12 months to assess the clinical and radiographic outcomes of treatment The data was analyzed using Chi-square, Cohen's kappa and t-tests Results There was no significant difference in the mean PI recorded during the 7 post-operative days between the two study arms (p = 0221) The clinical and radiographic success rates for PM

105 citations


Authors

Showing all 19557 results

NameH-indexPapersCitations
Paul F. Jacques11444654507
Mohammad Abdollahi90104535531
Fereidoun Azizi80127941755
Roya Kelishadi7385333681
Nima Rezaei72121526295
Neal D. Freedman6832716908
Jamie E Craig6838015956
Amir Hossein Mahvi6368615816
Adriano G. Cruz6134612832
Ali Montazeri6162517494
Parvin Mirmiran5663715420
Harry A. Lando532429432
Fatemeh Atyabi533109985
Daniel Granato532359406
Pejman Rohani5219213386
Network Information
Related Institutions (5)
Tehran University of Medical Sciences
57.2K papers, 878.5K citations

98% related

Shiraz University of Medical Sciences
21K papers, 247.5K citations

97% related

Mashhad University of Medical Sciences
18.7K papers, 252.5K citations

96% related

Isfahan University of Medical Sciences
19.5K papers, 248.6K citations

94% related

Tarbiat Modares University
32.6K papers, 526.3K citations

88% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202332
2022187
20214,346
20204,415
20193,809
20183,480