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Institution

Shanghai Jiao Tong University

EducationShanghai, Shanghai, China
About: Shanghai Jiao Tong University is a education organization based out in Shanghai, Shanghai, China. It is known for research contribution in the topics: Population & Cancer. The organization has 157524 authors who have published 184620 publications receiving 3451038 citations. The organization is also known as: Shanghai Communications University & Shanghai Jiaotong University.


Papers
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Journal ArticleDOI
TL;DR: HXD-AS1 is a prognostic marker for HCC patients and it may play a pro-metastatic role in hepatocarcinogenesis, and the results revealed that STAT3 could specifically interact with the promoter of HOXD -AS1 and activate HOXd-as1 transcription.
Abstract: Several of the thousands of human long noncoding RNAs (lncRNAs) have been functionally characterized, yet their potential involvement in hepatocellular carcinoma (HCC) remains poorly understood. LncRNA-HOXD-AS1 was identified by microarray and validated by real-time PCR. The clinicopathological significance of HOXD-AS1 was analyzed by Kaplan-Meier method. Chromatin immunoprecipitation was conducted to examine the mechanism of HOXD-AS1 upregulation. The role of HOXD-AS1 in HCC cells was assessed both in vitro and in vivo. ceRNA function of HOXD-AS1 was evaluated by RNA immunoprecipitation and biotin-coupled miRNA pull down assays. In this study, we found that HOXD-AS1 was significantly upregulated in HCC tissues. Clinical investigation demonstrated high expression level of HOXD-AS1 was associated with poor prognosis and high tumor node metastasis stage of HCC patients, and was an independent risk factor for survival. Moreover, our results revealed that STAT3 could specifically interact with the promoter of HOXD-AS1 and activate HOXD-AS1 transcription. Knockdown of HOXD-AS1 significantly inhibited migration and invasion of HCC cells in vitro and distant lung metastasis in vivo. Additionally, HOXD-AS1 was enriched in the cytoplasm, and shared miRNA response elements with SOX4. Overexpression of HOXD-AS1 competitively bound to miR-130a-3p that prevented SOX4 from miRNA-mediated degradation, thus activated the expression of EZH2 and MMP2 and facilitated HCC metastasis. In summary, HOXD-AS1 is a prognostic marker for HCC patients and it may play a pro-metastatic role in hepatocarcinogenesis.

381 citations

Journal ArticleDOI
TL;DR: Findings indicate that miR‐7 functions as a tumor suppressor and plays a substantial role in inhibiting the tumorigenesis and reversing the metastasis of HCC through the PI3K/Akt/mTOR‐signaling pathway in vitro and in vivo.

380 citations

Journal ArticleDOI
TL;DR: It is shown that CO acts genetically downstream of COP1 and CRY to regulate flowering time, and that CRY-mediated signal may negatively regulate COP1, thereby stabilizing CO, activating FT transcription, and inducing flowering.
Abstract: In Arabidopsis thaliana, the blue light photoreceptor cryptochromes (CRY) act to promote photomorphogenic development and the transition from vegetative to floral development in long days (LDs). We previously proposed that one of the mechanisms by which CRY regulates light responses is via its physical interaction with COP1, a RING motif-containing E3 ligase. Under LDs, the transcription of FLOWERING LOCUS T (FT) is activated by CONSTANS (CO) in leaf, and the FT protein moves to the shoot apex to induce flowering. CO protein is degraded in darkness, whereas it is stabilized by the CRY-mediated signal. However, the mechanism underlying this process is unknown. We show in this report that CO acts genetically downstream of COP1 and CRY to regulate flowering time. In addition, COP1 physically interacts with CO and functions as an E3 ligase, ubiquitinating CO in vitro and reducing CO levels in vivo. These results suggest that COP1 acts as a repressor of flowering by promoting the ubiquitin-mediated proteolysis of CO in darkness and that CRY-mediated signal may negatively regulate COP1, thereby stabilizing CO, activating FT transcription, and inducing flowering.

380 citations

Journal ArticleDOI
TL;DR: The significant OS benefit observed in patients treated with EGFR-TKI emphasises its contribution to improving survival of EGFR mutation-positive advanced non-small-cell lung cancer patients, suggesting that erlotinib should be considered standard first-line treatment of EGfr mutant patients and EGFR -TKI treatment following first- line therapy also brings significant benefits to those patients.

380 citations

Journal ArticleDOI
TL;DR: A taxonomy based on the layered model is presented and an extensive review on mmWave communications to point out the inadequacy of existing work and identify the future work.
Abstract: Millimeter wave (mmWave) communication has raised increasing attentions from both academia and industry due to its exceptional advantages. Compared with existing wireless communication techniques, such as WiFi and 4G, mmWave communications adopt much higher carrier frequencies and thus come with advantages including huge bandwidth, narrow beam, high transmission quality, and strong detection ability. These advantages can well address difficult situations caused by recent popular applications using wireless technologies. For example, mmWave communications can significantly alleviate the skyrocketing traffic demand of wireless communication from video streaming. Meanwhile, mmWave communications have several natural disadvantages, e.g., severe signal attenuation, easily blocked by obstacles, and small coverage, due to its short wavelengths. Hence, the major challenge is how to overcome its shortcomings while fully utilizing its advantages. In this paper, we present a taxonomy based on the layered model and give an extensive review on mmWave communications. Specially, we divide existing efforts into four categories that investigate: physical layer, medium access control (MAC) layer, network layer, and cross layer optimization, respectively. First, we present an overview of some technical details in physical layer. Second, we summarize available literature in MAC layer that pertains to protocols and scheduling schemes. Third, we make an in-depth survey of related research work in network layer, providing brain storming and methodology for enhancing the capacity and coverage of mmWave networks. Fourth, we analyze available research work related to cross layer allocation/optimization for mmWave communications. Fifth, we make a review of mmWave applications to illustrate how mmWave technology can be employed to satisfy other services. At the end of each section described above, we point out the inadequacy of existing work and identify the future work. Sixth, we present some available resources for mmWave communications, including related books about mmWave, commonly used mmWave frequencies, existing protocols based on mmWave, and experimental platforms. Finally, we have a simple summary and point out several promising future research directions.

380 citations


Authors

Showing all 158621 results

NameH-indexPapersCitations
Meir J. Stampfer2771414283776
Richard A. Flavell2311328205119
Jie Zhang1784857221720
Yang Yang1712644153049
Lei Jiang1702244135205
Gang Chen1673372149819
Thomas S. Huang1461299101564
Barbara J. Sahakian14561269190
Jean-Laurent Casanova14484276173
Kuo-Chen Chou14348757711
Weihong Tan14089267151
Xin Wu1391865109083
David Y. Graham138104780886
Bin Liu138218187085
Jun Chen136185677368
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023415
20222,315
202120,873
202019,462
201916,699
201814,250