Shanghai Jiao Tong University

About: Shanghai Jiao Tong University is a education organization based out in Shanghai, Shanghai, China. It is known for research contribution in the topics: Population & Cancer. The organization has 157524 authors who have published 184620 publications receiving 3451038 citations. The organization is also known as: Shanghai Communications University & Shanghai Jiaotong University.

GeoMAN: Multi-level Attention Networks for Geo-sensory Time Series Prediction

Abstract: Numerous sensors have been deployed in different geospatial locations to continuously and cooperatively monitor the surrounding environment, such as the air quality. These sensors generate multiple geo-sensory time series, with spatial correlations between their readings. Forecasting geo-sensory time series is of great importance yet very challenging as it is affected by many complex factors, i.e., dynamic spatio-temporal correlations and external factors. In this paper, we predict the readings of a geo-sensor over several future hours by using a multi-level attention-based recurrent neural network that considers multiple sensors' readings, meteorological data, and spatial data. More specifically, our model consists of two major parts: 1) a multi-level attention mechanism to model the dynamic spatio-temporal dependencies. 2) a general fusion module to incorporate the external factors from different domains. Experiments on two types of real-world datasets, viz., air quality data and water quality data, demonstrate that our method outperforms nine baseline methods.

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

Abstract: Although genetic factors contribute to almost half of all cases of deafness, treatment options for genetic deafness are limited. We developed a genome-editing approach to target a dominantly inherited form of genetic deafness. Here we show that cationic lipid-mediated in vivo delivery of Cas9-guide RNA complexes can ameliorate hearing loss in a mouse model of human genetic deafness. We designed and validated, both in vitro and in primary fibroblasts, genome editing agents that preferentially disrupt the dominant deafness-associated allele in the Tmc1 (transmembrane channel-like gene family 1) Beethoven (Bth) mouse model, even though the mutant Tmc1Bth allele differs from the wild-type allele at only a single base pair. Injection of Cas9-guide RNA-lipid complexes targeting the Tmc1Bth allele into the cochlea of neonatal Tmc1Bth/+ mice substantially reduced progressive hearing loss. We observed higher hair cell survival rates and lower auditory brainstem response thresholds in injected ears than in uninjected ears or ears injected with control complexes that targeted an unrelated gene. Enhanced acoustic startle responses were observed among injected compared to uninjected Tmc1Bth/+ mice. These findings suggest that protein-RNA complex delivery of target gene-disrupting agents in vivo is a potential strategy for the treatment of some types of autosomal-dominant hearing loss.

A uniformly valid analytic solution of two-dimensional viscous flow over a semi-infinite flat plate

Abstract: We apply a new kind of analytic technique, namely the homotopy analysis method (HAM), to give an explicit, totally analytic, uniformly valid solution of the two-dimensional laminar viscous flow over a semi-infinite flat plate governed by f‴(η)+αf(η)f″(η)+β[1−f′2(η)]=0 under the boundary conditions f(0)=f′(0)=0, f′(+∞)=1. This analytic solution is uniformly valid in the whole region 0[les ]η<+∞. For Blasius' (1908) flow (α=1/2, β=0), this solution converges to Howarth's (1938) numerical result and gives a purely analytic value f″(0)=0.332057. For the Falkner–Skan (1931) flow (α=1), it gives the same family of solutions as Hartree's (1937) numerical results and a related analytic formula for f″(0) when 2[ges ]β[ges ]0. Also, this analytic solution proves that when −0.1988[les ]β0 Hartree's (1937) family of solutions indeed possess the property that f′→1 exponentially as η→+∞. This verifies the validity of the homotopy analysis method and shows the potential possibility of applying it to some unsolved viscous flow problems in fluid mechanics.

Ultrathin Metal-Organic Framework Nanosheets with Ultrahigh Loading of Single Pt Atoms for Efficient Visible-Light-Driven Photocatalytic H 2 Evolution

Abstract: A surfactant-stabilized coordination strategy is used to make two-dimensional (2D) single-atom catalysts (SACs) with an ultrahigh Pt loading of 12.0 wt %, by assembly of pre-formed single Pt atom coordinated porphyrin precursors into free-standing metal-organic framework (MOF) nanosheets with an ultrathin thickness of 2.4±0.9 nm. This is the first example of 2D MOF-based SACs. Remarkably, the 2D SACs exhibit a record-high photocatalytic H2 evolution rate of 11 320 μmol g-1 h-1 via water splitting under visible light irradiation (λ>420 nm) compared with those of reported MOF-based photocatalysts. Moreover, the MOF nanosheets can be readily drop-casted onto solid substrates, forming thin films while still retaining their photocatalytic activity, which is highly desirable for practical solar H2 production.