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Institution

Shanghai Jiao Tong University

EducationShanghai, Shanghai, China
About: Shanghai Jiao Tong University is a education organization based out in Shanghai, Shanghai, China. It is known for research contribution in the topics: Population & Cancer. The organization has 157524 authors who have published 184620 publications receiving 3451038 citations. The organization is also known as: Shanghai Communications University & Shanghai Jiaotong University.


Papers
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Journal ArticleDOI
05 Jul 2019-Foods
TL;DR: Overall, garlic is an excellent natural source of bioactive sulfur-containing compounds and has promising applications in the development of functional foods or nutraceuticals for the prevention and management of certain diseases.
Abstract: Garlic (Allium sativum L.) is a widely consumed spice in the world. Garlic contains diverse bioactive compounds, such as allicin, alliin, diallyl sulfide, diallyl disulfide, diallyl trisulfide, ajoene, and S-allyl-cysteine. Substantial studies have shown that garlic and its bioactive constituents exhibit antioxidant, anti-inflammatory, antibacterial, antifungal, immunomodulatory, cardiovascular protective, anticancer, hepatoprotective, digestive system protective, anti-diabetic, anti-obesity, neuroprotective, and renal protective properties. In this review, the main bioactive compounds and important biological functions of garlic are summarized, highlighting and discussing the relevant mechanisms of actions. Overall, garlic is an excellent natural source of bioactive sulfur-containing compounds and has promising applications in the development of functional foods or nutraceuticals for the prevention and management of certain diseases.

359 citations

Journal ArticleDOI
TL;DR: It is demonstrated that metformin, at doses that lead to activation of the AMP-activated protein kinase (AMPK), significantly increases the generation of both intracellular and extracellular Aβ species, suggesting a potentially harmful consequence of this widely prescribed antidiabetic drug when used as a monotherapy in elderly diabetic patients.
Abstract: Epidemiological, clinical and experimental evidence suggests a link between type 2 diabetes and Alzheimer's disease (AD). Insulin modulates metabolism of beta-amyloid precursor protein (APP) in neurons, decreasing the intracellular accumulation of beta-amyloid (Abeta) peptides, which are pivotal in AD pathogenesis. The present study investigates whether the widely prescribed insulin-sensitizing drug, metformin (Glucophage(R)), affects APP metabolism and Abeta generation in various cell models. We demonstrate that metformin, at doses that lead to activation of the AMP-activated protein kinase (AMPK), significantly increases the generation of both intracellular and extracellular Abeta species. Furthermore, the effect of metformin on Abeta generation is mediated by transcriptional up-regulation of beta-secretase (BACE1), which results in an elevated protein level and increased enzymatic activity. Unlike insulin, metformin exerts no effect on Abeta degradation. In addition, we found that glucose deprivation and various tyrphostins, known inhibitors of insulin-like growth factors/insulin receptor tyrosine kinases, do not modulate the effect of metformin on Abeta. Finally, inhibition of AMP-activated protein kinase (AMPK) by the pharmacological inhibitor Compound C largely suppresses metformin's effect on Abeta generation and BACE1 transcription, suggesting an AMPK-dependent mechanism. Although insulin and metformin display opposing effects on Abeta generation, in combined use, metformin enhances insulin's effect in reducing Abeta levels. Our findings suggest a potentially harmful consequence of this widely prescribed antidiabetic drug when used as a monotherapy in elderly diabetic patients.

359 citations

Journal ArticleDOI
TL;DR: Mouse esophageal tumor growth was found to be significantly inhibited by the photothermal effect of Fe3O4 nanoparticles, resulting in effective tumor reduction, and a morphological examination revealed that after a photothermal therapy, the tumor tissue structure exhibited discontinuation, the cells were significantly shriveled and some cells have finally disintegrated.

358 citations

Journal ArticleDOI
TL;DR: The finding that the onset of human disc degeneration occurs as early as by adolescence is indicated, because they are the major causes of the biologic changes experienced by disc cells.

358 citations

Journal ArticleDOI
TL;DR: High levels of similarity have been shown between the networks of pollen development in Arabidopsis and rice, which will serve as valuable tools to understand and manipulate this developmental pathway further in plants.
Abstract: The control of male fertility is of vital importance for crop breeding, hybrid generation, and the control of pollen release. Recent development in the analysis of Arabidopsis male sterile mutants has meant that there is a greater understanding of the gene regulatory networks controlling maternal development of the anther and the resultant sporophytes. With the advent of the genome sequence and tools to allow the analysis of gene function, this knowledge base is now extending into the monocot crop rice. This has shown high levels of similarity between the networks of pollen development in Arabidopsis and rice, which will serve as valuable tools to understand and manipulate this developmental pathway further in plants.

358 citations


Authors

Showing all 158621 results

NameH-indexPapersCitations
Meir J. Stampfer2771414283776
Richard A. Flavell2311328205119
Jie Zhang1784857221720
Yang Yang1712644153049
Lei Jiang1702244135205
Gang Chen1673372149819
Thomas S. Huang1461299101564
Barbara J. Sahakian14561269190
Jean-Laurent Casanova14484276173
Kuo-Chen Chou14348757711
Weihong Tan14089267151
Xin Wu1391865109083
David Y. Graham138104780886
Bin Liu138218187085
Jun Chen136185677368
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023415
20222,315
202120,873
202019,462
201916,699
201814,250