Shanghai Jiao Tong University

About: Shanghai Jiao Tong University is a education organization based out in Shanghai, Shanghai, China. It is known for research contribution in the topics: Population & Cancer. The organization has 157524 authors who have published 184620 publications receiving 3451038 citations. The organization is also known as: Shanghai Communications University & Shanghai Jiaotong University.

Limits on Spin-Dependent WIMP-Nucleon Cross Sections from 225 Live Days of XENON100 Data

Abstract: We present new experimental constraints on the elastic, spin-dependent WIMP-nucleon cross section using recent data from the XENON100 experiment, operated in the Laboratori Nazionali del Gran Sasso in Italy. An analysis of 224.6 live days×34 kg of exposure acquired during 2011 and 2012 revealed no excess signal due to axial-vector WIMP interactions with Xe129 and Xe131 nuclei. This leads to the most stringent upper limits on WIMP-neutron cross sections for WIMP masses above 6 GeV/c2, with a minimum cross section of 3.5×10−40 cm2 at a WIMP mass of 45 GeV/c2, at 90% confidence level.

Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Abstract: Aberrant protein misfolding may contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS) but the detailed mechanisms are largely unknown. Our previous study has shown that autophagy is altered in the mouse model of ALS. In the present study, we systematically investigated the correlation of the autophagic alteration with the motor neurons (MNs) degeneration in the ALS mice. We have demonstrated that the autophagic protein marker LC3-II is markedly and specifically increased in the spinal cord MNs of the ALS mice. Electron microscopy and immunochemistry studies have shown that autophagic vacuoles are significantly accumulated in the dystrophic axons of spinal cord MNs of the ALS mice. All these changes in the ALS mice appear at the age of 90 d when the ALS mice display modest clinical symptoms; and they become prominent at the age of 120 d. The clinical symptoms are correlated with the progression of MNs degeneration. Moreover, we have found that p62/SQSTM1 is accumulated progressively in the spinal cord, indicating that the possibility of impaired autophagic flux in the SOD1(G93A) mice. Furthermore, to our surprise, we have found that treatment with autophagy enhancer rapamycin accelerates the MNs degeneration, shortens the life span of the ALS mice, and has no obvious effects on the accumulation of SOD1 aggregates. In addition, we have demonstrated that rapamycin treatment in the ALS mice causes more severe mitochondrial impairment, higher Bax levels and greater caspase-3 activation. These findings suggest that selective degeneration of MNs is associated with the impairment of the autophagy pathway and that rapamycin treatment may exacerbate the pathological processing through apoptosis and other mechanisms in the ALS mice.

A new Boussinesq method for fully nonlinear waves from shallow to deep water

Abstract: A new method valid for highly dispersive and highly nonlinear water waves is presented. It combines a time-stepping of the exact surface boundary conditions with an approximate series expansion solution to the Laplace equation in the interior domain. The starting point is an exact solution to the Laplace equation given in terms of infinite series expansions from an arbitrary z-level. We replace the infinite series operators by finite series (Boussinesq-type) approximations involving up to fifth-derivative operators. The finite series are manipulated to incorporate Pade approximants providing the highest possible accuracy for a given number of terms. As a result, linear and nonlinear wave characteristics become very accurate up to wavenumbers as high as kh = 40, while the vertical variation of the velocity field becomes applicable for kh up to 12. These results represent a major improvement over existing Boussinesq-type formulations in the literature. A numerical model is developed in a single horizontal dimension and it is used to study phenomena such as solitary waves and their impact on vertical walls, modulational instability in deep water involving recurrence or frequency downshift, and shoaling of regular waves up to breaking in shallow water.

Diffusion engineering of ions and charge carriers for stable efficient perovskite solar cells

Abstract: Long-term stability is crucial for the future application of perovskite solar cells, a promising low-cost photovoltaic technology that has rapidly advanced in the recent years. Here, we designed a nanostructured carbon layer to suppress the diffusion of ions/molecules within perovskite solar cells, an important degradation process in the device. Furthermore, this nanocarbon layer benefited the diffusion of electron charge carriers to enable a high-energy conversion efficiency. Finally, the efficiency on a perovskite solar cell with an aperture area of 1.02 cm2, after a thermal aging test at 85 °C for over 500 h, or light soaking for 1,000 h, was stable of over 15% during the entire test. The present diffusion engineering of ions/molecules and photo generated charges paves a way to realizing long-term stable and highly efficient perovskite solar cells. Ion migration in perovskite solar cells are known to cause hysteresis and instability. Biet al., report a charge extraction layer based on graphene, fullerenes and carbon quantum dots which suppresses ion diffusion and enhances charge carrier diffusion leading to efficient devices with improved stability.

Poststroke Dementia

Abstract: Stroke is a major cause of death in the elderly, and risk of dementia increases after stroke. Poststroke dementia （PSD） covers all types of dementia after stroke, and is an important cause of disability in the elderly. The prevalence of PSD varies from 31.4% to 21.5% in 3 months to 4 years after the stroke. Its incidence increases with time after the stroke. Stroke and dementia share a number of risk factors. Stroke can be the direct cause of dementia and may also produce dementia by precipitating the onset of degenerative disease. Key words: stroke ; dementia ; Alzheimer＇s disease ; risk factor