Institution
Shanghai Jiao Tong University
Education•Shanghai, Shanghai, China•
About: Shanghai Jiao Tong University is a education organization based out in Shanghai, Shanghai, China. It is known for research contribution in the topics: Population & Cancer. The organization has 157524 authors who have published 184620 publications receiving 3451038 citations. The organization is also known as: Shanghai Communications University & Shanghai Jiaotong University.
Topics: Population, Cancer, Computer science, Microstructure, Medicine
Papers published on a yearly basis
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China Medical University (PRC)1, Zhengzhou University2, Guangxi Medical University3, Xi'an Jiaotong University4, Huazhong University of Science and Technology5, Chinese PLA General Hospital6, Third Military Medical University7, Dalian Medical University8, Nanchang University9, Harbin Medical University10, Central South University11, Nanjing University of Chinese Medicine12, Fujian Medical University13, Lanzhou University14, Sichuan University15, Jilin University16, Shanghai University17, Sun Yat-sen University18, Shanxi Medical University19, Chinese Center for Disease Control and Prevention20, Guiyang Medical University21, Hebei Medical University22, First Affiliated Hospital of Xinjiang Medical University23, Tianjin Medical University General Hospital24, Shanghai Jiao Tong University25, Shandong University26
TL;DR: The prevalence of diabetes has increased slightly from 2007 to 2017 among adults living in China and the findings indicate that diabetes is an important public health problem in China.
Abstract: Objective To assess the prevalence of diabetes and its risk factors. Design Population based, cross sectional study. Setting 31 provinces in mainland China with nationally representative cross sectional data from 2015 to 2017. Participants 75 880 participants aged 18 and older—a nationally representative sample of the mainland Chinese population. Main outcome measures Prevalence of diabetes among adults living in China, and the prevalence by sex, regions, and ethnic groups, estimated by the 2018 American Diabetes Association (ADA) and the World Health Organization diagnostic criteria. Demographic characteristics, lifestyle, and history of disease were recorded by participants on a questionnaire. Anthropometric and clinical assessments were made of serum concentrations of fasting plasma glucose (one measurement), two hour plasma glucose, and glycated haemoglobin (HbA1c). Results The weighted prevalence of total diabetes (n=9772), self-reported diabetes (n=4464), newly diagnosed diabetes (n=5308), and prediabetes (n=27 230) diagnosed by the ADA criteria were 12.8% (95% confidence interval 12.0% to 13.6%), 6.0% (5.4% to 6.7%), 6.8% (6.1% to 7.4%), and 35.2% (33.5% to 37.0%), respectively, among adults living in China. The weighted prevalence of total diabetes was higher among adults aged 50 and older and among men. The prevalence of total diabetes in 31 provinces ranged from 6.2% in Guizhou to 19.9% in Inner Mongolia. Han ethnicity had the highest prevalence of diabetes (12.8%) and Hui ethnicity had the lowest (6.3%) among five investigated ethnicities. The weighted prevalence of total diabetes (n=8385) using the WHO criteria was 11.2% (95% confidence interval 10.5% to 11.9%). Conclusion The prevalence of diabetes has increased slightly from 2007 to 2017 among adults living in China. The findings indicate that diabetes is an important public health problem in China.
689 citations
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TL;DR: The paradox in the rationales of two opposite ROS-manipulation strategies and the concerns for their use are discussed, as well as a combinational set of cellular parameters including redox status, antioxidant enzymes expression, cell signaling and transcription factor activation profiles, namely "redox signaling signature", is waiting for being developed in order to choose ROS-elevating or ROS-depleting therapy specific to certain type of cancer cells.
Abstract: Reactive oxygen species (ROS) act as a second messenger in cell signaling and are essential for various biological processes in normal cells. Any aberrance in redox balance may relate to human path...
687 citations
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TL;DR: It is demonstrated that the expression of mSOD1G93A results in activated and neurotoxic microglia, and suggested that the lack of m SOD1 G93A expression inmicroglia may contribute to motoneuron protection, and confirmed the importance of microglio as a double-edged sword.
Abstract: The most common inherited form of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting adult motoneurons, is caused by dominant mutations in the ubiquitously expressed Cu2+/Zn2+ superoxide dismutase (SOD1). Recent studies suggest that glia may contribute to motoneuron injury in animal models of familial ALS. To determine whether the expression of mutant SOD1 (mSOD1G93A) in CNS microglia contributes to motoneuron injury, PU.1−/− mice that are unable to develop myeloid and lymphoid cells received bone marrow transplants resulting in donor-derived microglia. Donor-derived microglia from mice overexpressing mSOD1G93A, an animal model of familial ALS, transplanted into PU.1−/− mice could not induce weakness, motoneuron injury, or an ALS-like disease. To determine whether expression of mSOD1G93A in motoneurons and astroglia, as well as microglia, was required to produce motoneuron disease, PU.1−/− mice were bred with mSOD1G93A mice. In mSOD1G93A/PU.1−/− mice, wild-type donor-derived microglia slowed motoneuron loss and prolonged disease duration and survival when compared with mice receiving mSOD1G93A expressing cells or mSOD1G93A mice. In vitro studies confirmed that wild-type microglia were less neurotoxic than similarly cultured mSOD1G93A microglia. Compared with wild-type microglia, mSOD1G93A microglia produced and released more superoxide and nitrite+nitrate, and induced more neuronal death. These data demonstrate that the expression of mSOD1G93A results in activated and neurotoxic microglia, and suggests that the lack of mSOD1G93A expression in microglia may contribute to motoneuron protection. This study confirms the importance of microglia as a double-edged sword, and focuses on the importance of targeting microglia to minimize cytotoxicity and maximize neuroprotection in neurodegenerative diseases.
687 citations
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TL;DR: A synthesis of 727 tests of the stress-gradient hypothesis in plant communities across the globe shows that plant interactions change with stress through an outright shift to facilitation (survival) or a reduction in competition (growth and reproduction).
Abstract: The study of positive species interactions is a rapidly evolving field in ecology. Despite decades of research, controversy has emerged as to whether positive and negative interactions predictably shift with increasing environmental stress as hypothesised by the stress-gradient hypothesis (SGH). Here, we provide a synthesis of 727 tests of the SGH in plant communities across the globe to examine its generality across a variety of ecological factors. Our results show that plant interactions change with stress through an outright shift to facilitation (survival) or a reduction in competition (growth and reproduction). In a limited number of cases, plant interactions do not respond to stress, but they never shift towards competition with stress. These findings are consistent across stress types, plant growth forms, life histories, origins (invasive vs. native), climates, ecosystems and methodologies, though the magnitude of the shifts towards facilitation with stress is dependent on these factors. We suggest that future studies should employ standardised definitions and protocols to test the SGH, take a multi-factorial approach that considers variables such as plant traits in addition to stress, and apply the SGH to better understand how species and communities will respond to environmental change.
685 citations
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TL;DR: Recent and in-progress state-of-the-art advancements in the application of core-shell nanoarchitecture strategies to design and prepare high-k polymer nanocomposites are summarized.
Abstract: High-k polymer nanocomposites have considerable potential in energy storage and dielectric applications because of their ease of processing, flexibility, and low cost. Core-shell nanoarchitecture strategies are versatile and powerful tools for the design and synthesis of advanced high-k polymer nanocomposites. Recent and in-progress state-of-the-art advancements in the application of core-shell nanoarchitecture strategies to design and prepare high-k polymer nanocomposites are summarized. Special focus is directed to emphasizing their advantages over conventional melt-mixing and solution-mixing methods: first, homogeneous nanoparticle dispersion can be easily achieved even in highly loaded nanocomposites; second, the dielectric constant of the nanocomposites can be effectively enhanced and meanwhile the high breakdown strength can be well-preserved; third, for nanocomposites filled with electrically conductive nanoparticles, dielectric loss can be effectively surpressed, and meanwhile a high dielectric constant can be achieved. In addition, fundamental insights into the roles of the interfaces on the dielectric properties of the nanocomposites can be probed. The last part of the article is concluded with current problems and future perspectives of utilizing the core-shell nanoarchitecture strategies for the development of high-k polymer nanocomposites.
683 citations
Authors
Showing all 158621 results
Name | H-index | Papers | Citations |
---|---|---|---|
Meir J. Stampfer | 277 | 1414 | 283776 |
Richard A. Flavell | 231 | 1328 | 205119 |
Jie Zhang | 178 | 4857 | 221720 |
Yang Yang | 171 | 2644 | 153049 |
Lei Jiang | 170 | 2244 | 135205 |
Gang Chen | 167 | 3372 | 149819 |
Thomas S. Huang | 146 | 1299 | 101564 |
Barbara J. Sahakian | 145 | 612 | 69190 |
Jean-Laurent Casanova | 144 | 842 | 76173 |
Kuo-Chen Chou | 143 | 487 | 57711 |
Weihong Tan | 140 | 892 | 67151 |
Xin Wu | 139 | 1865 | 109083 |
David Y. Graham | 138 | 1047 | 80886 |
Bin Liu | 138 | 2181 | 87085 |
Jun Chen | 136 | 1856 | 77368 |