Shanghai Normal University

About: Shanghai Normal University is a education organization based out in Shanghai, China. It is known for research contribution in the topics: Catalysis & Mesoporous material. The organization has 9011 authors who have published 9512 publications receiving 160507 citations.

Hydrophilic Cu9S5 Nanocrystals: A Photothermal Agent with a 25.7% Heat Conversion Efficiency for Photothermal Ablation of Cancer Cells in Vivo

Abstract: Photothermal ablation (PTA) therapy has a great potential to revolutionize conventional therapeutic approaches for cancers, but it has been limited by difficulties in obtaining biocompatible photothermal agents that have low cost, small size (<100 nm), and high photothermal conversion efficiency. Herein, we have developed hydrophilic plate-like Cu(9)S(5) nanocrystals (NCs, a mean size of ∼70 nm × 13 nm) as a new photothermal agent, which are synthesized by combining a thermal decomposition and ligand exchange route. The aqueous dispersion of as-synthesized Cu(9)S(5) NCs exhibits an enhanced absorption (e.g., ∼1.2 × 10(9) M(-1) cm(-1) at 980 nm) with the increase of wavelength in near-infrared (NIR) region, which should be attributed to localized surface plasmon resonances (SPR) arising from p-type carriers. The exposure of the aqueous dispersion of Cu(9)S(5) NCs (40 ppm) to 980 nm laser with a power density of 0.51 W/cm(2) can elevate its temperature by 15.1 °C in 7 min; a 980 nm laser heat conversion efficiency reaches as high as 25.7%, which is higher than that of the as-synthesized Au nanorods (23.7% from 980 nm laser) and the recently reported Cu(2-x)Se NCs (22% from 808 nm laser). Importantly, under the irradiation of 980 nm laser with the conservative and safe power density over a short period (∼10 min), cancer cells in vivo can be efficiently killed by the photothermal effects of the Cu(9)S(5) NCs. The present finding demonstrates the promising application of the Cu(9)S(5) NCs as an ideal photothermal agent in the PTA of in vivo tumor tissues.

Hydrophilic flower-like CuS superstructures as an efficient 980 nm laser-driven photothermal agent for ablation of cancer cells.

Abstract: Photothermal ablation (PTA) therapy has attracted much interest in recent years as a minimally invasive alternative to conventional approaches, such as surgery and chemotherapy, for therapeutic intervention of specifi c biological targets. [ 1 , 2 ] In particular, near-infrared (NIR, λ = 700–1100 nm) laser-induced PTA, which converts NIR optical energy into thermal energy, has attracted increasing attention, because the NIR laser is absorbed less by biological tissues and the typical penetration depth of the NIR (such as 980 nm) light can be several centimeters in biological tissues. [ 3 , 4 ] A prerequisite for the development of the NIR laser-induced PTA is to gain access to biocompatible and effi cient photothermal coupling agents. As the well-known NIR photothermal conversion agents, gold (Au) nanostructures, including supramolecularly assembled nanoparticles, [ 5–8 ]

CFHTLenS: the Canada-France-Hawaii Telescope Lensing Survey

Abstract: We present the Canada–France–Hawaii Telescope Lensing Survey (CFHTLenS) that accurately determines a weak gravitational lensing signal from the full 154 deg^2 of deep multicolour data obtained by the CFHT Legacy Survey. Weak gravitational lensing by large-scale structure is widely recognized as one of the most powerful but technically challenging probes of cosmology. We outline the CFHTLenS analysis pipeline, describing how and why every step of the chain from the raw pixel data to the lensing shear and photometric redshift measurement has been revised and improved compared to previous analyses of a subset of the same data. We present a novel method to identify data which contributes a non-negligible contamination to our sample and quantify the required level of calibration for the survey. Through a series of cosmology-insensitive tests we demonstrate the robustness of the resulting cosmic shear signal, presenting a science-ready shear and photometric redshift catalogue for future exploitation.