Shanghai University

About: Shanghai University is a education organization based out in Shanghai, Shanghai, China. It is known for research contribution in the topics: Microstructure & Graphene. The organization has 59583 authors who have published 56840 publications receiving 753549 citations. The organization is also known as: Shànghǎi Dàxué.

Fabrication of compressible and recyclable macroscopic g-C3N4/GO aerogel hybrids for visible-light harvesting: A promising strategy for water remediation

Abstract: Herein, a g-C3N4/GO aerogel hybrid with macroscopic 3D architecture is fabricated and applied in visible-light-induced water mediation. The composite photocatalyst with compressibility and recyclability is extraordinarily suitable for practical application. The morphologies and properties are carefully characterized, suggesting g-C3N4 is well decorated on the surface of GO by π-π stacking and the GO sheets are well interlaced. A moderate amount of g-C3N4 in the hybrid is beneficial to photocatalytic activity for dyes and bromates. When the mass ratio of g-C3N4 and GO is 3:5, the % degradation of MO and MB (20 mg L−1) can reach ∼90% in 40 min visible-light illumination, and%conversion of bromate (250 μg L−1) can be obtained almost 80% in 60 min illumination. Underlying premise of maintaining intact macro appearance, the photocatalytic performance of the hybrid scarcely any lowers after 5 successive runs on degradation of MO, and the mass loss is below 4%. The composite mainly interacts with the contaminants by π-π adsorption, implying it can be an important broad-spectrum photocatalyst since most of the contaminants in the environments contain π-bond structure. Through scavenger experiments and ESR determination, peroxide radical anions are proven as the predominant species during the photodegradation processes.

MicroRNA-144 inhibits the metastasis of gastric cancer by targeting MET expression

Abstract: Gastric cancer (GC) remains one of the most common types of malignant cancer, and the molecular mechanism underlying its metastasis is still largely unclear. MicroRNAs have emerged as important regulators of metastasis because of their ability to act on multiple signaling pathways. In our study, we found that miR-144 is significantly downregulated in both highly metastatic GC cell lines and tissues. Results from both gain-of-function and loss-of-function experiments demonstrate that increased miR-144 expression significantly reduced GC cell migration, whereas decreased miR-144 expression dramatically enhanced GC cell migration. The met proto-oncogene (MET), which is often amplified in human cancers and functions as an important regulator of cell growth and tumor invasion, was identified as a direct target of miR-144. Moreover, silencing of MET using small interfering RNA (siRNA) recapitulated the anti-metastatic function of miR-144, whereas restoring MET expression attenuated the function of miR-144 in GC cells. Furthermore, we found that miR-144, by targeting MET, suppresses phosphorylation of Akt. Finally, we observed an inverse correlation between the expression of miR-144 and MET mRNA in GC metastatic tissues. In summary, miR-144 suppresses GC progression by directly downregulating MET expression, which subsequently prevents activation of the pro-oncogenic Akt pathway. Reintroduction of miR-144 expression in GC cells presents an attractive therapeutic approach to block the metastasis of gastric cancer.