Shanghai University

About: Shanghai University is a education organization based out in Shanghai, Shanghai, China. It is known for research contribution in the topics: Microstructure & Catalysis. The organization has 59583 authors who have published 56840 publications receiving 753549 citations. The organization is also known as: Shànghǎi Dàxué.

Domino Condensation/S-Arylation/Heterocyclization Reactions: Copper-Catalyzed Three-Component Synthesis of 2-N-Substituted Benzothiazoles†

Abstract: A new method for the synthesis of benzothiazoles with a nitrogen substituent in the 2-position is reported.

Epidermal growth factor receptor (EGFR): A rising star in the era of precision medicine of lung cancer

Abstract: // Xiaomin Liu 1, * , Ping Wang 1, * , Caiyan Zhang 1 and Zhongliang Ma 1 1 Lab for Noncoding RNA and Cancer, School of Life Sciences, Shanghai University, 200444 Shanghai, China * These authors contributed equally to this work Correspondence to: Zhongliang Ma, email: zlma@shu.edu.cn Keywords: epidermal growth factor receptor (EGFR), noncoding RNA, precision medicine, lung cancer Received: October 11, 2016 Accepted: March 24, 2017 Published: April 05, 2017 ABSTRACT Lung cancer is a leading cause of cancer mortality worldwide. In tumors, the important role of noncoding RNA regulatory networks has been more and more reveal. EGFR has been identified as an oncogenic driver of NSCLC, especially activating mutations EGFR and its inhibition with specific TKIs can generate dramatic tumor responses. Studies have shown that EGFR plays significant roles in the progression of NSCLC. Subset analysis of the small proportion of patients with EGFR-mutant lung cancer showed a disease-free survival benefit, but was underpowered to detect a survival advantage. Herein, we highlight the progression of EGFR, noncoding RNA, and their roles in carcinogenesis. We also focus on anti-lung cancer drug development and EGFR-related drug resistance.

Injury-Activated Transforming Growth Factor β Controls Mobilization of Mesenchymal Stem Cells for Tissue Remodeling

Abstract: Upon secretion, transforming growth factor β (TGFβ) is maintained in a sequestered state in extracellular matrix as a latent form. The latent TGFβ is considered as a molecular sensor that releases active TGFβ in response to the perturbations of the extracellular matrix at the situations of mechanical stress, wound repair, tissue injury, and inflammation. The biological implication of the temporal discontinuity of TGFβ storage in the matrix and its activation is obscure. Here, using several animal models in which latent TGFβ is activated in vascular matrix in response to injury of arteries, we show that active TGFβ controls the mobilization and recruitment of mesenchymal stem cells (MSCs) to participate in tissue repair and remodeling. MSCs were mobilized into the peripheral blood in response to vascular injury and recruited to the injured sites where they gave rise to both endothelial cells for re-endothelialization and myofibroblastic cells to form thick neointima. TGFβs were activated in the vascular matrix in both rat and mouse models of mechanical injury of arteries. Importantly, the active TGFβ released from the injured vessels is essential to induce the migration of MSCs, and cascade expression of monocyte chemotactic protein-1 stimulated by TGFβ amplifies the signal for migration. Moreover, sustained high levels of active TGFβ were observed in peripheral blood, and at the same time points following injury, Sca1+ CD29+ CD11b- CD45- MSCs, in which 91% are nestin+ cells, were mobilized to peripheral blood and recruited to the remodeling arteries. Intravenously injection of recombinant active TGFβ1 in uninjured mice rapidly mobilized MSCs into circulation. Furthermore, inhibitor of TGFβ type I receptor blocked the mobilization and recruitment of MSCs to the injured arteries. Thus, TGFβ is an injury-activated messenger essential for the mobilization and recruitment of MSCs to participate in tissue repair/remodeling.

Point-of-care testing detection methods for COVID-19.

Abstract: COVID-19 is an acute respiratory disease caused by SARS-CoV-2, which has high transmissibility. People infected with SARS-CoV-2 can develop symptoms including cough, fever, pneumonia and other complications, which in severe cases could lead to death. In addition, a proportion of people infected with SARS-CoV-2 may be asymptomatic. At present, the primary diagnostic method for COVID-19 is reverse transcription-polymerase chain reaction (RT-PCR), which tests patient samples including nasopharyngeal swabs, sputum and other lower respiratory tract secretions. Other detection methods, e.g., isothermal nucleic acid amplification, CRISPR, immunochromatography, enzyme-linked immunosorbent assay (ELISA) and electrochemical sensors are also in use. As the current testing methods are mostly performed at central hospitals and third-party testing centres, the testing systems used mostly employ large, high-throughput, automated equipment. Given the current situation of the epidemic, point-of-care testing (POCT) is advantageous in terms of its ease of use, greater approachability on the user's end, more timely detection, and comparable accuracy and sensitivity, which could reduce the testing load on central hospitals. POCT is thus conducive to daily epidemic control and achieving early detection and treatment. This paper summarises the latest research advances in POCT-based SARS-CoV-2 detection methods, compares three categories of commercially available products, i.e., nucleic acid tests, immunoassays and novel sensors, and proposes the expectations for the development of POCT-based SARS-CoV-2 detection including greater accessibility, higher sensitivity and lower costs.

N,P-Codoped Meso-/Microporous Carbon Derived from Biomass Materials via a Dual-Activation Strategy as High-Performance Electrodes for Deionization Capacitors

Abstract: Nitrogen and phosphorus codoped meso-/microporous carbon derived from biomass materials has been designed and successfully fabricated as high-performance electrodes for deionization capacitors. The obtained materials were prepared by the pyrolysis of pomelo peel via a dual-activation strategy by using NH4H2PO4 and KHCO3. It is interesting that the as prepared nitrogen and phosphorus codoped meso-/microporous carbon possesses a high specific surface area of 2726 m2 g–1 with high percentage of mesopores of 52%. It has been demonstrated that the obtained electrode shows high specific capacitance, low inner resistance and good wettability. Consequently, the obtained electrode exhibits good deionization performance in a 300–1000 mg L–1 NaCl solution at 1.0–1.4 V with a flow rate of 20–60 mL min–1. The electrode reveals an ultrahigh deionization capacity of 20.78 mg g–1 at 1.4 V in a 1000 mg L–1 NaCl solution. The regeneration performance of the obtained electrode is good. The good performance is ascribed to th...