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Institution

Shanmugha Arts, Science, Technology & Research Academy

EducationThanjavur, Tamil Nadu, India
About: Shanmugha Arts, Science, Technology & Research Academy is a education organization based out in Thanjavur, Tamil Nadu, India. It is known for research contribution in the topics: Encryption & Thin film. The organization has 3858 authors who have published 4125 publications receiving 60706 citations. The organization is also known as: Shanmugha Arts, Science, Technology & Research Academy.


Papers
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Journal ArticleDOI
TL;DR: The advances made toward understanding the basis of cancer immune evasion are discussed, the efficacy of various therapeutic measures and targets that have been developed or are being investigated to enhance tumor rejection are summarized and some natural agents and phytochemicals merit further study.
Abstract: Cancer immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Although considerable progress has been made in understanding how cancers evade destructive immunity, measures to counteract tumor escape have not kept pace. There are a number of factors that contribute to tumor persistence despite having a normal host immune system. Immune editing is one of the key aspects why tumors evade surveillance causing the tumors to lie dormant in patients for years through "equilibrium" and "senescence" before re-emerging. In addition, tumors exploit several immunological processes such as targeting the regulatory T cell function or their secretions, antigen presentation, modifying the production of immune suppressive mediators, tolerance and immune deviation. Besides these, tumor heterogeneity and metastasis also play a critical role in tumor growth. A number of potential targets like promoting Th1, NK cell, γδ T cell responses, inhibiting Treg functionality, induction of IL-12, use of drugs including phytochemicals have been designed to counter tumor progression with much success. Some natural agents and phytochemicals merit further study. For example, use of certain key polysaccharide components from mushrooms and plants have shown to possess therapeutic impact on tumor-imposed genetic instability, anti-growth signaling, replicative immortality, dysregulated metabolism etc. In this review, we will discuss the advances made toward understanding the basis of cancer immune evasion and summarize the efficacy of various therapeutic measures and targets that have been developed or are being investigated to enhance tumor rejection.

1,064 citations

Journal ArticleDOI
01 Feb 2013
TL;DR: Future investigations should endeavor at adopting logistic and sensible entrapment techniques along with innovatively modified supports to improve the state of enzyme immobilization and provide new perspectives to the industrial sector.
Abstract: The current demands of the world’s biotechnological industries are enhancement in enzyme productivity and development of novel techniques for increasing their shelf life. These requirements are inevitable to facilitate large-scale and economic formulation. Enzyme immobilization provides an excellent base for increasing availability of enzyme to the substrate with greater turnover over a considerable period of time. Several natural and synthetic supports have been assessed for their efficiency for enzyme immobilization. Nowadays, immobilized enzymes are preferred over their free counterpart due to their prolonged availability that curtails redundant downstream and purification processes. Future investigations should endeavor at adopting logistic and sensible entrapment techniques along with innovatively modified supports to improve the state of enzyme immobilization and provide new perspectives to the industrial sector.

1,009 citations

Journal ArticleDOI
TL;DR: In this article, a review article gives an overview of recent advances in the development of hybrid supercapacitors, storage mechanism, criteria of formation, components, different electrode and electrolyte materials, electrochemical profile assessment, design fabrication and their applications.
Abstract: Hybrid supercapacitors with their improved performance in energy density without altering their power density have been in trend since recent years. The hybrid supercapacitor delivers higher specific capacitance in comparison to the existing electric double layer capacitor (EDLC) and pseudocapacitors. Generally, the asymmetric behavior of hybrid supercapacitors which is the combination of EDLC and pseudocapacitor acts as an enhancer in its respective capacitance values. This asymmetric approach marks a new beginning towards the much-needed pollution free, long lasting and proficient energy-storing performance. Corresponding to their utilization in hybrid electric vehicles and similar sort of power necessity based devices; the research in developing new advanced storage devices finds an enormous and vast future ahead. The most significant factor for the energy efficient applications demands a considerably higher ratio of surface to the volume by incorporation of new materials. This review article gives an overview of recent advances in the development of hybrid supercapacitors, storage mechanism, criteria of formation, components, different electrode and electrolyte materials, electrochemical profile assessment, design fabrication and their applications.

862 citations

Journal ArticleDOI
TL;DR: In this article, the toxicity mechanisms of various metal ions and their relationship towards the induction of oxidative stress have been summarized, and electrochemical biosensors employed in the detection of metal ions with various interfaces have been highlighted.
Abstract: Most of the metal ions are carcinogens and lead to serious health concerns by producing free radicals. Hence, fast and accurate detection of metal ions has become a critical issue. Among various metal ions arsenic, cadmium, lead, mercury and chromium are considered to be highly toxic. To detect these metal ions, electrochemical biosensors with interfaces such as microorganisms, enzymes, microspheres, nanomaterials like gold, silver nanoparticles, CNTs, and metal oxides have been developed. Among these, nanomaterials are considered to be most promising, owing to their strong adsorption, fast electron transfer kinetics, and biocompatibility, which are very apt for biosensing applications. The coupling of electrochemical techniques with nanomaterials has enhanced the sensitivity, limit of detection, and robustness of the sensors. In this review, toxicity mechanisms of various metal ions and their relationship towards the induction of oxidative stress have been summarized. Also, electrochemical biosensors employed in the detection of metal ions with various interfaces have been highlighted.

730 citations

Journal ArticleDOI
TL;DR: A review of the most recent works in electronic noses used in the food industry is presented in this paper, focusing on the applications within food quality monitoring that is, meat, milk, fish, tea, coffee and wines.
Abstract: This paper provides a review of the most recent works in electronic noses used in the food industry. Focus is placed on the applications within food quality monitoring that is, meat, milk, fish, tea, coffee and wines. This paper demonstrates that there is a strong commonality between the different application area in terms of the sensors used and the data processing algorithms applied. Further, this paper provides a critical outlook on the developments needed in this field for transitioning from research platforms to industrial instruments applied in real contexts.

574 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202322
202287
2021188
2020174
2019222
2018342