Shiv Nadar University

About: Shiv Nadar University is a education organization based out in Dadri, Uttar Pradesh, India. It is known for research contribution in the topics: Population & Graphene. The organization has 1015 authors who have published 1924 publications receiving 18420 citations.

Scattering and absorption properties of near-surface aerosol over Gangetic–Himalayan region: the role of boundary-layer dynamics and long-range transport

Abstract: . Light scattering and absorption properties of atmospheric aerosols are of vital importance for evaluating their types, sources and radiative forcing. This is of particular interest over the Gangetic–Himalayan (GH) region due to uplift of aerosol from the plains to the Himalayan range, causing serious effects on atmospheric heating, glaciology and monsoon circulation. In this respect, the Ganges Valley Aerosol Experiment (GVAX) was initiated in Nainital from June 2011 to March 2012 with the aim of examining the aerosol properties, source regions, uplift mechanisms and aerosol–radiation–cloud interactions. The present study examines the temporal (diurnal, monthly, seasonal) evolution of scattering (σ

Linear programming with Triangular Intuitionistic Fuzzy Number

Abstract: This paper presents an approach based on value and ambiguity indexes defined in [1] to solve linear programming problems with data as triangular intuitionistic fuzzy numbers.

Genome-wide analysis reveals downregulation of miR-379/miR-656 cluster in human cancers

Abstract: MicroRNAs (miRNAs) are non-uniformly distributed in genomes and ~30% of the miRNAs in the human genome are clustered. In this study we have focused on the imprinted miRNA cluster miR-379/miR-656 on 14q32.31 (hereafter C14) to test their coordinated function. We have analyzed expression profile of >1000 human miRNAs in >1400 samples representing seven different human tissue types obtained from cancer patients along with matched and unmatched controls. We found 68% of the miRNAs in this cluster to be significantly downregulated in glioblastoma multiforme (GBM), 61% downregulated in kidney renal clear cell carcinoma (KIRC), 46% in breast invasive carcinoma (BRCA) and 14% in ovarian serous cystadenocarcinoma (OV). On a genome-wide scale C14 miRNAs accounted for 12-30% of the total downregulated miRNAs in different cancers. Pathway enrichment for the predicted targets of C14 miRNA was significant for cancer pathways, especially Glioma (p< 3.77x10-6, FDR<0.005). The observed downregulation was confirmed in GBM patients by real-time PCR, where 79% of C14 miRNAs (34/43) showed downregulation. In GBM samples, hypermethylation at C14 locus (p<0.003) and downregulation of MEF2, a crucial transcription factor for the cluster was observed which likely contribute to the observed downregulation of the entire miRNA cluster. We provide compelling evidence that the entire C14 miRNA cluster is a tumor suppressor locus involved in multiple cancers, especially in GBM, and points toward a general mechanism of coordinated function for clustered miRNAs. Reviewed by: Prof. Gregory J Goodall and Dr. Alexander Max Burroughs