Shiv Nadar University

About: Shiv Nadar University is a education organization based out in Dadri, Uttar Pradesh, India. It is known for research contribution in the topics: Population & Graphene. The organization has 1015 authors who have published 1924 publications receiving 18420 citations.

Prediction and analysis of particulate matter (PM2.5 and PM10) concentrations using machine learning techniques

Abstract: The National Capital Region (NCR) encircling the capital of India is the one of the most polluted regions in the world. Poor air quality is a cause of a number of diseases and reduction in life span. Particulate matter (PM) is the most significant as well as the most hazardous air pollutant in this region. This work proposes to build models to analyze and forecast PM concentrations at a location in the NCR. The correlation between PM concentrations in different seasons and with meteorological parameters and other air pollutants is studied to determine the most suitable explanatory variables for building the forecast models. The performance of the proposed models is evaluated with the help of variable importance ranking (VIR), partial plots and measures such as mean error, absolute mean error and root mean square error.

A novel ZVS quasi-resonant DC-link PWM inverter with minimum voltage stress across the switches

Abstract: This paper presents a new quasi-resonant DC-link (QRDCL) PWM inverter with zero voltage switching (ZVS) capability. The proposed quasi-resonant circuit creates zero voltage intervals in the DC-link to facilitate ZVS of the inverter switches under all operating conditions. This is achieved with the DC-link voltage being clamped at the source voltage V, using minimum additional components. It requires only two additional switches compared to the conventional PWM converter. Moreover, the control circuit is not called upon to control the inductor current, as it is the case with other circuits of the same family. Hence, it doesn't require any current sensing device, thereby, making the control circuit simple and cheap. The operating principle of the circuit is explained and detailed analysis of each operating mode is given. A design criterion for achieving ZVS is obtained from the mathematical analysis. The feasibility of the proposed circuit operation has been verified by PSPICE simulation. The simulation results show full ZVS for both the proposed circuit and the PWM inverter.

In silico analysis of calcium binding pocket of perforin like protein 1: insights into the regulation of pore formation.

Abstract: Plasmodium falciparum perforin like proteins (PfPLPs) are an important arsenal for the entry and exit of malaria parasites. These proteins bind and oligomerize on the membrane in calcium dependent manner and form an open pore. The calcium dependent pore forming activity of PLPs is usually conferred by their C2 like C-terminal domain. Here, we have tried to elucidate the calcium binding residues in the C-terminal domain of PfPLP1, a member of P. falciparum PLPs, playing a crucial role in calcium dependent egress of blood stage parasites. Through our in silico study, we have found that the C-terminal domain of all PfPLPs is rich in β-pleated sheets and is structurally similar to C2 domain of human perforin. Furthermore, homology search based on 3-D structure of PfPLP1 confirmed that it is structurally homologous to the calcium binding C2 domain of many proteins. On further elucidation of the calcium-binding pocket of the C2 like domain of PfPLP1 showed that it binds to two calcium molecules. The calcium-binding pocket could be a target of novel chemotherapeutics for studying functional role of PfPLPs in parasite biology as well as for limiting blood stage growth of malaria parasite.