Institution
Shriners Hospitals for Children - Galveston
Healthcare•Galveston, Texas, United States•
About: Shriners Hospitals for Children - Galveston is a healthcare organization based out in Galveston, Texas, United States. It is known for research contribution in the topics: Burn injury & Lean body mass. The organization has 249 authors who have published 420 publications receiving 15311 citations.
Papers published on a yearly basis
Papers
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TL;DR: It is shown that DNA adducts detectable by their ability to block PCR amplification form in the rat hippocampus after acute exposure to smoke, while mismatched bases emerged at the later recovery times, potentially due to an erroneous DNA repair process.
30 citations
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TL;DR: Results indicate that the resistance of SIRS mice to infectious complications is impaired by AAMφ generated from RMφ in response to SirS‐associated CCL2 production.
Abstract: Infection associated with systemic inflammatory response syndrome (SIRS) is a major cause of morbidity and mortality in patients with major surgery, polytrauma, and severe burn injury. In previous studies, mice with severe pancreatitis (a mouse model of SIRS, SIRS mice) have been shown to be greatly susceptible to various infections. In the present study, a mechanism involved in the impaired resistance of SIRS mice to infectious complications was investigated. Sera from SIRS mice impaired the resistance of normal mice to infectious complications induced by cecal ligation and puncture (CLP). CC chemokine ligand 2 (CCL2) was detected in sera of SIRS mice. Resident macrophages (RMphi) cultured with SIRS mouse sera converted to alternatively activated macrophages (AAMphi), which were also demonstrated in mice treated with recombinant murine CCL2. However, AAMphi were not demonstrated in mice injected with SIRS mouse sera and anti-CCL2 monoclonal antibody (mAb) in combination. Furthermore, normal mice that received SIRS mouse sera and anti-CCL2 mAb resisted CLP-induced infectious complications. These results indicate that the resistance of SIRS mice to infectious complications is impaired by AAMphi generated from RMphi in response to SIRS-associated CCL2 production.
29 citations
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TL;DR: Recommendations based on the limited evidence found in the literature as well as the expert opinion of burn rehabilitation specialists are described to guide those rehabilitation professionals who treat burn survivors during their acute hospitalization.
28 citations
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TL;DR: Results indicate that PMN-II appearing in response to burn injury impair host antibacterial resistance against sepsis stemming from E. faecalis translocation through the conversion of resident M φ to alternatively activated Mφ.
Abstract: Thermally injured mice are susceptible to Enterococcus faecalis translocation. In this study, the role of polymorphonuclear neutrophils (PMN) on the development of sepsis stemming from E. faecalis translocation was studied in SCID-beige (SCIDbg) mice depleted of PMN (SCIDbgN mice) or macrophages (Mphi) and PMN (SCIDbgMN mice). Sepsis was not developed in SCIDbgN mice orally infected with E. faecalis, while the orally infected pathogen spread systemically in the same mice inoculated with PMN from thermally injured mice (TI-PMN). SCIDbgMN mice were shown to be greatly susceptible to sepsis caused by E. faecalis translocation, while orally infected E. faecalis did not spread into sepsis in the same mice that were previously inoculated with Mphi from unburned SCIDbg mice (resident Mphi). In contrast, orally infected E. faecalis spread systemically in SCIDbgMN mice inoculated with resident Mphi and TI-PMN, while all SCIDbgMN mice inoculated in combination with resident Mphi and PMN from unburned SCIDbg mice survived after the infection. After cultivation with TI-PMN in a dual-chamber transwell, resident Mphi converted to alternatively activated Mphi, which are inhibitory on the generation of classically activated Mphi (typical effector cells in host antibacterial innate immunities). TI-PMN were characterized as immunosuppressive PMN (PMN-II) with abilities to produce cc-chemokine ligand-2 and IL-10. These results indicate that PMN-II appearing in response to burn injury impair host antibacterial resistance against sepsis stemming from E. faecalis translocation through the conversion of resident Mphi to alternatively activated Mphi.
28 citations
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Boston University1, Bentley University2, Beijing Institute of Foreign Trade3, Harvard University4, Shriners Hospitals for Children - Galveston5, Shriners Hospitals for Children6, Nebraska Medical Center7, University of Florida8, Kennedy Krieger Institute9, Boston Children's Hospital10, Spaulding Rehabilitation Hospital11
TL;DR: This study demonstrates significant deficits in multiple functional domains across pediatric burn survivors compared with controls, and shows recovery curves can be used to recognize deviation from the expected course and tailor care to patient needs.
Abstract: IMPORTANCE: Patient-reported outcomes serving as benchmarks for recovery of pediatric burn survivors are lacking, and new approaches using longitudinal cohorts for monitoring their expected recovery based on statistical models are needed for patient management during the early years following the burn. OBJECTIVE: To describe multidimensional patient-reported outcomes among pediatric burn survivors younger than 5 years to establish benchmarks using recovery curve methods. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study of pediatric burn survivors younger than 5 years at 12 burn centers. Age-matched nonburned reference groups were studied to define expected results in normal growth and development. The Burn Outcomes Questionnaire for children aged 0 to 5 years (BOQ0-5) was administered to parents of children who had burns and were younger than 5 years. Mixed models were used to generate 48-month recovery curves for each of the 10 BOQ0-5 domains. The study was conducted between January 1999 and December 2008. MAIN OUTCOMES AND MEASURES: The 10 BOQ0-5 domains including play, language, fine motor skills, gross motor skills, emotional behavior, family functioning, pain/itching, appearance, satisfaction with care, and worry/concern up to 48 months after burn injury. RESULTS: A total of 336 pediatric burn survivors younger than 5 years (mean [SD] age, 2.0 [1.2] years; 58.4% male; 60.2% white, 18.6% black, and 12.0% Hispanic) and 285 age-matched nonburned controls (mean [SD] age, 2.4 [1.3] years; 51.1% male; 67.1% white, 8.9% black, and 15.0% Hispanic) completed the study. Predicted scores improved exponentially over time for 5 of the BOQ0-5 domains (predicted scores at 1 month vs 24 months: play, 48.6 vs 52.1 [P RESULTS: = .03]; language, 49.2 vs 54.4 [P RESULTS: CONCLUSIONS AND RELEVANCE: This study demonstrates significant deficits in multiple functional domains across pediatric burn survivors compared with controls. Recovery curves can be used to recognize deviation from the expected course and tailor care to patient needs. Language: en
28 citations
Authors
Showing all 250 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert R. Wolfe | 124 | 566 | 54000 |
Csaba Szabó | 123 | 958 | 61791 |
David N. Herndon | 108 | 1227 | 54888 |
Steven E. Wolf | 74 | 419 | 21329 |
Blake B. Rasmussen | 65 | 152 | 18951 |
Marc G. Jeschke | 64 | 174 | 13903 |
Daniel L. Traber | 62 | 629 | 14801 |
Nicole S. Gibran | 60 | 273 | 14304 |
Donald S. Prough | 58 | 508 | 11644 |
David L. Chinkes | 56 | 151 | 11871 |
Labros S. Sidossis | 53 | 224 | 11636 |
Robert E. Barrow | 51 | 130 | 7114 |
Ashok K. Chopra | 49 | 199 | 7568 |
James A. Carson | 49 | 157 | 7554 |
Celeste C. Finnerty | 48 | 172 | 10647 |