Institution
Shriners Hospitals for Children - Galveston
Healthcare•Galveston, Texas, United States•
About: Shriners Hospitals for Children - Galveston is a healthcare organization based out in Galveston, Texas, United States. It is known for research contribution in the topics: Burn injury & Lean body mass. The organization has 249 authors who have published 420 publications receiving 15311 citations.
Papers published on a yearly basis
Papers
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TL;DR: Folate supplementation has a stimulatory effect on wound DNA synthesis, which would be expected to accelerate wound healing and is essential for tissue repair by a mechanism that increases net protein deposition in the wound.
13 citations
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TL;DR: Both apoptosis and proliferation increased in gut epithelial cells of mice without IL-1 receptors, suggesting increased cell turnover with no change in net balance.
Abstract: Mucosal epithelium is maintained by a balance in turnover between cell proliferation and cell death by apoptosis. Dysregulation of gut cellular turnover has been implicated in several diseases, among them the modulation of sepsis and multiorgan failure after injury, inflammatory bowel disease, and cancer. Severe cutaneous burn has been shown to cause atrophy of small bowel mucosa, 1–3 which is associated with accelerated turnover of gut epithelial cells. 4 The causes of the increased rates of cellular apoptosis and proliferation are not known.
Burn injury increases expression of several cytokines, one of which is interleukin-1β (IL-1β). 5 IL-1β plays a role in both cell death and survival under appropriate conditions:
1. IL-1β pretreatment rendered glomerular mesangial cells more susceptible to apoptotic death from oxidant stress. 6
2. IL-1β induced thyrocyte apoptosis, which was blocked by the addition of Fas antibodies. 7
3. Treatment of pancreatic islet cells with a combination of IL-1β, tumor necrosis factor (TNF)-α, and interferon-γ increased cell death by apoptosis. 8
4. IL-1β type I receptor antagonist inhibited apoptosis in neurons and fibroblasts. 9
5. Pretreatment with mature IL-1β provided an antiapoptotic effect for induced apoptosis, which was attributed to downregulation of the receptor and thus the signal. 9
Others have shown that IL-1 is a growth factor for a variety of cells. 10,11 For example, IL-1 protects fibroblasts against TNF-mediated cell death by arresting cell cycling. 12
With these findings, we wondered whether IL-1β plays a role in gut mucosal cell turnover by influencing apoptotic cell death. Our hypothesis was that loss of the IL-1 signal would decrease gut epithelial cell apoptosis and improve cell survival. We chose to test this hypothesis in vivo in IL-1 receptor type I knockout mice.
13 citations
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TL;DR: The data suggest that burn trauma alters the expression, trafficking, and degradation of β-ARs in dermal fibroblasts, which may then affect fibroblast responses to propranolol.
12 citations
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TL;DR: FSCs showed that FSCs reduced the need for autografting of deep second degree burns, with little hypertrophy of new skin and no skin contraction.
Abstract: The management of patients with partial thickness (second degree) burns is problematic due to the different treatments needed for varying depths of injury A report recently published in The Lancet describes a novel treatment for deep second degree burns using a fetal skin construct (FSC) The authors included eight pediatric patients with small second degree burns They showed that FSCs reduced the need for autografting of deep second degree burns, with little hypertrophy of new skin and no skin contraction This technology is new and exciting, but in our opinion several issues must be addressed before FSCs can enter the clinical arena All of the patients were included in the treatment group, and therefore no comparison with conventional skin substitutes was possible There is no mention of the use of laser Doppler in any initial assessment of patients The debridement carried out before application of the FSC is not elaborated upon, and the surface areas involved in the study were very small in most cases, which limits the relevance to patients with larger burns The use of FSCs gives us an additional option in a range of possible treatments for this notoriously difficult-to-treat patient group
12 citations
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TL;DR: This exploratory mixed-methods study is to determine how two different parent groups (English speaking and Spanish speaking) understand medical care for their children and the procedural and research consent forms required by that care.
Abstract: Health literacy—the ability to read, understand, and use health information to make health care decisions—affects health care outcomes, hospitalization costs, and readmission. The purpose of this exploratory mixed-methods study is to determine how two different parent groups (English speaking and Spanish speaking) understand medical care for their children and the procedural and research consent forms required by that care. Quantitative and qualitative data are gathered and compared concurrently. Differences between groups are found in age, grade completed, Short Test of Functional Health Literacy in Adults scores, and ways of understanding health information. Identifying how parents understand health information is the first step in providing effective family-centered health care education.
12 citations
Authors
Showing all 250 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert R. Wolfe | 124 | 566 | 54000 |
Csaba Szabó | 123 | 958 | 61791 |
David N. Herndon | 108 | 1227 | 54888 |
Steven E. Wolf | 74 | 419 | 21329 |
Blake B. Rasmussen | 65 | 152 | 18951 |
Marc G. Jeschke | 64 | 174 | 13903 |
Daniel L. Traber | 62 | 629 | 14801 |
Nicole S. Gibran | 60 | 273 | 14304 |
Donald S. Prough | 58 | 508 | 11644 |
David L. Chinkes | 56 | 151 | 11871 |
Labros S. Sidossis | 53 | 224 | 11636 |
Robert E. Barrow | 51 | 130 | 7114 |
Ashok K. Chopra | 49 | 199 | 7568 |
James A. Carson | 49 | 157 | 7554 |
Celeste C. Finnerty | 48 | 172 | 10647 |