scispace - formally typeset
Search or ask a question
Institution

Shriners Hospitals for Children - Galveston

HealthcareGalveston, Texas, United States
About: Shriners Hospitals for Children - Galveston is a healthcare organization based out in Galveston, Texas, United States. It is known for research contribution in the topics: Burn injury & Lean body mass. The organization has 249 authors who have published 420 publications receiving 15311 citations.


Papers
More filters
Journal ArticleDOI
01 Aug 2018-Burns
TL;DR: The burn injury does not have sex-dependent effects on LBM or exercise capacity in severely burn injured children and differences in relative peak VO2 and peak HR suggest the need for burn specific exercise programs for improving the efficacy of a rehabilitation program.

3 citations

Journal ArticleDOI
TL;DR: The protective effects of FL treatment after burn injury are mediated by both pDCs and cDCs, and pharmacological enhancement of both DC subtypes by FL is a potential therapeutic intervention to enhance immune responses to infection and improve outcome after burn injuries.
Abstract: Patients experiencing large thermal injuries are susceptible to opportunistic infections that can delay recovery and lead to sepsis. Dendritic cells (DC) are important for the detection of pathogens and activation of the innate and acquired immune responses. DCs are significantly decreased in burn patients early after injury, and the development of sepsis is associated with persistent DC depletion. In a murine model of burn wound infection, the enhancement of DCs after injury by treatment with the DC growth factor Fms-like tyrosine kinase-3 ligand (FL) enhances neutrophil migration to infection, improves bacterial clearance, and increases survival in a DC-dependent manner. FL expands the production of both conventional DCs (cDC) and plasmacytoid DCs (pDC). It has been established that cDCs are required for some of the protective effects of FL after burn injury. This study was designed to determine the contribution of the pDC subset. Mice were subjected to full-thickness scald burns under deep anesthesia and were provided analgesia. pDCs were depleted by injection of anti-plasmacytoid dendritic cell antigen-1 antibodies. Survival, bacterial clearance, and neutrophil responses in vivo and in vitro were measured. Depletion of preexisting pDCs, but not FL-expanded pDCs, abrogated the beneficial effects of FL on survival, bacterial clearance, and neutrophil migration in response to burn wound infection. This requisite role of pDCs for FL-mediated enhancement of neutrophil migratory capacity is not due to direct effects of pDCs on neutrophils. cDCs, but not pDCs, directly increased neutrophil migratory capacity after co-culture. The protective effects of FL treatment after burn injury are mediated by both pDCs and cDCs. Pharmacological enhancement of both DC subtypes by FL is a potential therapeutic intervention to enhance immune responses to infection and improve outcome after burn injury.

3 citations

Journal ArticleDOI
TL;DR: In women, blood cells contribute to plasma acyl-CNT levels and the acyl -CNT production is linked to plasma palmitate oxidation, a marker of whole-body fat metabolism.

3 citations


Authors

Showing all 250 results

NameH-indexPapersCitations
Robert R. Wolfe12456654000
Csaba Szabó12395861791
David N. Herndon108122754888
Steven E. Wolf7441921329
Blake B. Rasmussen6515218951
Marc G. Jeschke6417413903
Daniel L. Traber6262914801
Nicole S. Gibran6027314304
Donald S. Prough5850811644
David L. Chinkes5615111871
Labros S. Sidossis5322411636
Robert E. Barrow511307114
Ashok K. Chopra491997568
James A. Carson491577554
Celeste C. Finnerty4817210647
Network Information
Related Institutions (5)
University of Texas Medical Branch
38.2K papers, 1.5M citations

81% related

Georgia Regents University
28.3K papers, 992.3K citations

79% related

Rush University Medical Center
29K papers, 1.3M citations

79% related

Thomas Jefferson University
38.2K papers, 1.7M citations

79% related

Vanderbilt University Medical Center
34.6K papers, 1.1M citations

79% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20221
20215
202026
201928
201822
201746