Sichuan University

About: Sichuan University is a education organization based out in Chengdu, China. It is known for research contribution in the topics: Population & Catalysis. The organization has 107623 authors who have published 102844 publications receiving 1612131 citations. The organization is also known as: Sìchuān Dàxué.

Ultrathin flexible reduced graphene oxide/cellulose nanofiber composite films with strongly anisotropic thermal conductivity and efficient electromagnetic interference shielding

Abstract: With the extensive use of portable and wearable electronic devices, ultrathin electromagnetic interference (EMI) shielding materials with excellent thermal management are increasingly desirable. In this study, ultrathin and highly aligned reduced graphene oxide (RGO)/cellulose nanofiber (CNF) composite films with excellent EMI shielding performance and strong anisotropy of thermal conductivity were fabricated by vacuum-assisted filtration followed by hydroiodic acid (HI) reduction. The obtained 50 wt% RGO/CNF composite films, which are only ≈23 μm in thickness, possess the remarkable electrical conductivity of ≈4057.3 S m−1 and outstanding EMI shielding effectiveness (SE) of ≈26.2 dB owning to the uniform dispersion and self-alignment into the layered structure of RGO. In addition, the RGO/CNF composite films with 50 wt% RGO loadings possess high in-plane thermal conductivity (K ≈ 7.3 W m−1 K−1) and, unexpectedly, very low cross-plane thermal conductivity (K⊥ ≈ 0.13 W m−1 K−1), resulting in strong anisotropy of the thermal conductivity (K/K⊥ ≈ 56). Thus, these ultrathin RGO/CNF composite films have great application potential as effective lightweight shielding materials against electromagnetic microwaves and heat, especially in flexible portable electronic devices and wearable devices.

Overcoming cancer therapeutic bottleneck by drug repurposing

Abstract: Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated the development of the alternative strategy of drug repurposing, the development of old drugs for new therapeutic purposes. This strategy with a cost-effective way offers a rare opportunity for the treatment of human neoplastic disease, facilitating rapid clinical translation. With an increased understanding of the hallmarks of cancer and the development of various data-driven approaches, drug repurposing further promotes the holistic productivity of drug discovery and reasonably focuses on target-defined antineoplastic compounds. The “treasure trove” of non-oncology drugs should not be ignored since they could target not only known but also hitherto unknown vulnerabilities of cancer. Indeed, different from targeted drugs, these old generic drugs, usually used in a multi-target strategy may bring benefit to patients. In this review, aiming to demonstrate the full potential of drug repurposing, we present various promising repurposed non-oncology drugs for clinical cancer management and classify these candidates into their proposed administration for either mono- or drug combination therapy. We also summarize approaches used for drug repurposing and discuss the main barriers to its uptake.

New Understanding in Tuning Toughness of β-Polypropylene: The Role of β-Nucleated Crystalline Morphology

Abstract: It is widely believed that the trigonal β-form is favorable and effective for toughening isotactic polypropylene (iPP). Therefore, β-form content should be achieved as high as possible to realize excellent toughness in iPP. However, in this study, we demonstrate that the connection between crystallites might mainly determine the toughness of iPP instead of the β-crystal content. A new rare earth nucleator (WBG) was used to generate the rich β-crystalline structure in the compression-molded bars that were fabricated upon different molten temperatures (Tf). Interestingly, the increase in tensile elongation can be as large as 8 times for increased Tf. The polymorphic composition and overall crystallinity of β-nucleated iPP are almost independent of Tf. Nevertheless, the β-nucleated crystalline morphology has completely changed. Three types of β-crystalline morphology, namely, β-spherulite, β-transcrystalline entity, and “flower”-like agglomerate of β-crystallites, are sequentially obtained with increasing Tf...