Sichuan University

About: Sichuan University is a education organization based out in Chengdu, China. It is known for research contribution in the topics: Catalysis & Population. The organization has 107623 authors who have published 102844 publications receiving 1612131 citations. The organization is also known as: Sìchuān Dàxué.

Secure Beamforming for MIMO Broadcasting With Wireless Information and Power Transfer

Abstract: This paper considers a basic MIMO information-energy broadcast system, where a multi-antenna transmitter transmits information and energy simultaneously to a multi-antenna information receiver and a dual-functional multi-antenna energy receiver which is also capable of decoding information. Due to the open nature of wireless medium and the dual purpose of information and energy transmission, secure information transmission while ensuring efficient energy harvesting is a critical issue for such a broadcast system. Providing that physical layer security techniques are adopted for secure transmission, we study beamforming design to maximize the achievable secrecy rate subject to a total power constraint and an energy harvesting constraint. First, based on semidefinite relaxation, we propose global optimal solutions to the secrecy rate maximization (SRM) problem in the single-stream case and a specific full-stream case. Then, we propose inexact block coordinate descent (IBCD) algorithm to tackle the SRM problem of general case with arbitrary number of streams. We prove that the IBCD algorithm can monotonically converge to a Karush-Kuhn-Tucker (KKT) solution to the SRM problem. Furthermore, we extend the IBCD algorithm to the joint beamforming and artificial noise design problem. Finally, simulations are performed to validate the effectiveness of the proposed beamforming algorithms.

Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress.

Abstract: Endoplasmic reticulum (ER) is a dynamic organelle orchestrating the folding and post-translational maturation of almost all membrane proteins and most secreted proteins. These proteins synthesized in the ER, need to form disulfide bridge to acquire specific three-dimensional structures for function. The formation of disulfide bridge is mediated via protein disulfide isomerase (PDI) family and other oxidoreductases, which contribute to reactive oxygen species (ROS) generation and consumption in the ER. Therefore, redox regulation of ER is delicate and sensitive to perturbation. Deregulation in ER homeostasis, usually called ER stress, can provoke unfolded protein response (UPR) pathways with an aim to initially restore homeostasis by activating genes involved in protein folding and antioxidative machinery. Over time, however, activated UPR involves a variety of cellular signaling pathways which determine the state and fate of cell in large part (like autophagy, apoptosis, ferroptosis, inflammation, senescence, stemness, and cell cycle, etc.). This review will describe the regulation of UPR from the redox perspective in controlling the cell survival or death, emphasizing the redox modifications of UPR sensors/transducers in the ER.

Oxidative stress and diabetes: antioxidative strategies

Abstract: Diabetes mellitus is one of the major public health problems worldwide. Considerable recent evidence suggests that the cellular reduction-oxidation (redox) imbalance leads to oxidative stress and subsequent occurrence and development of diabetes and related complications by regulating certain signaling pathways involved in β-cell dysfunction and insulin resistance. Reactive oxide species (ROS) can also directly oxidize certain proteins (defined as redox modification) involved in the diabetes process. There are a number of potential problems in the clinical application of antioxidant therapies including poor solubility, storage instability and nonselectivity of antioxidants. Novel antioxidant delivery systems may overcome pharmacokinetic and stability problem and improve the selectivity of scavenging ROS. We have therefore focused on the role of oxidative stress and antioxidative therapies in the pathogenesis of diabetes mellitus. Precise therapeutic interventions against ROS and downstream targets are now possible and provide important new insights into the treatment of diabetes.