Institution
Sichuan University
Education•Chengdu, China•
About: Sichuan University is a education organization based out in Chengdu, China. It is known for research contribution in the topics: Population & Catalysis. The organization has 107623 authors who have published 102844 publications receiving 1612131 citations. The organization is also known as: Sìchuān Dàxué.
Topics: Population, Catalysis, Cancer, Adsorption, Randomized controlled trial
Papers published on a yearly basis
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Zhengzhou University1, Anhui Medical University2, Xinjiang Medical University3, Shihezi University4, Henan University5, Capital Medical University6, Henan University of Science and Technology7, Shandong University8, Inner Mongolia Medical University9, Shantou University10, Sichuan University11, Nanjing Medical University12, Fujian Medical University13, Kunming Institute of Zoology14, Beijing Jishuitan Hospital15, Zhejiang University16, University of Illinois at Chicago17, University of Medicine and Dentistry of New Jersey18, Peking University19
TL;DR: A previously unknown susceptibility locus for ESCC is identified: PLCE1 at 10q23, which might regulate cell growth, differentiation, apoptosis and angiogenesis and has important biological implications for both ESCC and GCA.
Abstract: Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54.
364 citations
University of Queensland1, Changi General Hospital2, Tan Tock Seng Hospital3, National University of Singapore4, The Chinese University of Hong Kong5, Sichuan University6, University of the Philippines7, University of Malaya8, Kyung Hee University9, Taipei Veterans General Hospital10, Dalhousie University11, Centre Hospitalier Universitaire de Toulouse12, Capital Medical University13, Catholic University of the Sacred Heart14, Columbia University15, Saint Louis University16, University of Western Australia17
TL;DR: The recommendations provided herein are intended for use by healthcare providers in their management of older adults with frailty in the Asia Pacific region and it is proposed that regional guideline support committees be formed to help provide regular updates to these evidence-based guidelines.
363 citations
TL;DR: This work uniformly captures and maintains primitive neural stem cells from hESCs that can stably self-renew in the presence of leukemia inhibitory factor, GSK3 inhibitor, and TGF-β receptor inhibitor and exhibit in vivo integration.
Abstract: Human embryonic stem cells (hESCs) hold enormous promise for regenerative medicine. Typically, hESC-based applications would require their in vitro differentiation into a desirable homogenous cell population. A major challenge of the current hESC differentiation paradigm is the inability to effectively capture and, in the long-term, stably expand primitive lineage-specific stem/precursor cells that retain broad differentiation potential and, more importantly, developmental stage-specific differentiation propensity. Here, we report synergistic inhibition of glycogen synthase kinase 3 (GSK3), transforming growth factor β (TGF-β), and Notch signaling pathways by small molecules can efficiently convert monolayer cultured hESCs into homogenous primitive neuroepithelium within 1 wk under chemically defined condition. These primitive neuroepithelia can stably self-renew in the presence of leukemia inhibitory factor, GSK3 inhibitor (CHIR99021), and TGF-β receptor inhibitor (SB431542); retain high neurogenic potential and responsiveness to instructive neural patterning cues toward midbrain and hindbrain neuronal subtypes; and exhibit in vivo integration. Our work uniformly captures and maintains primitive neural stem cells from hESCs.
362 citations
TL;DR: In this review, the barriers to brain-targeted drug delivery are reviewed, including the BBB, blood–brain tumor barrier (BBTB), and nose-to-brain barrier, and delivery strategies are focused on overcoming theBBB, directly targeting diseased cells in the brain, and dual- targeted delivery.
361 citations
TL;DR: The research and development of CHW related areas are much slower than those of CW, however, CHWs are still of strategic importance in the resource scarcity periods because of their abundant availability and special properties.
361 citations
Authors
Showing all 108474 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Jie Zhang | 178 | 4857 | 221720 |
| Robin M. Murray | 171 | 1539 | 116362 |
| Xiang Zhang | 154 | 1733 | 117576 |
| Rui Zhang | 151 | 2625 | 107917 |
| Xiaoyuan Chen | 149 | 994 | 89870 |
| Yi Yang | 143 | 2456 | 92268 |
| Xinliang Feng | 134 | 721 | 73033 |
| Chuan He | 130 | 584 | 66438 |
| Lei Zhang | 130 | 2312 | 86950 |
| Jian Zhou | 128 | 3007 | 91402 |
| Shaobin Wang | 126 | 872 | 52463 |
| Yi Xie | 126 | 745 | 62970 |
| Pak C. Sham | 124 | 866 | 100601 |
| Wei Chen | 122 | 1946 | 89460 |
| Bo Wang | 119 | 2905 | 84863 |