Institution
Sofia University
Education•Sofia, Bulgaria•
About: Sofia University is a education organization based out in Sofia, Bulgaria. It is known for research contribution in the topics: Large Hadron Collider & Standard Model. The organization has 8533 authors who have published 15730 publications receiving 306320 citations. The organization is also known as: University of Sofia & BFUS.
Topics: Large Hadron Collider, Standard Model, Population, Lepton, Laser
Papers published on a yearly basis
Papers
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TL;DR: A composite catalytic system that achieves realistic mimicry of cytochrome P-450 as well as catalytic turnover rates that make the system industrially viable is reported, suggesting close mechanistic similarities to the enzymatic process.
Abstract: MANY attempts have been made to mimic the catalytic oxidative properties of the enzyme cytochrome P-450. For homogeneous systems1 the mechanisms of oxidation can be readily determined but proper mimicry of the protein environment is difficult to achieve. Heterogeneous mimics have been designed that use organometallic complexes encapsulated in the supercages of zeolites2,3, which enables control of selectivity and inhibition of auto-oxidation. But these systems do not show any mechanistic analogy with the enzymatic process, and the oxidation rates tend to be low. Here we report a composite catalytic system that achieves realistic mimicry of cytochrome P-450 as well as catalytic turnover rates that make the system industrially viable. Our catalyst incorporates iron phthalocyanine complexes encapsulated in crystals of zeolite Y, which are in turn embedded in a polydi-methylsiloxane membrane. The polymer acts as a mimic of the phospholipid membrane in which cytochrome P-450 resides4, acting as an interface between two immiscible phases and avoiding the need for solvents or phase-transfer agents. This system oxidizes alkanes at room temperature at rates comparable to those of the enzyme5. The observation of a large kinetic isotope effect and the preferential oxidation of tertiary C–H bonds suggest close mechanistic similarities to the enzymatic process.
266 citations
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TL;DR: For the first time, predictions from pythia8 obtained with tunes based on NLO or NNLO PDFs are shown to reliably describe minimum-bias and underlying-event data with a similar level of agreement to predictions from tunes using LO PDF sets.
Abstract: New sets of CMS underlying-event parameters (“tunes”) are presented for the pythia8 event generator. These tunes use the NNPDF3.1 parton distribution functions (PDFs) at leading (LO), next-to-leading (NLO), or next-to-next-to-leading (NNLO) orders in perturbative quantum chromodynamics, and the strong coupling evolution at LO or NLO. Measurements of charged-particle multiplicity and transverse momentum densities at various hadron collision energies are fit simultaneously to determine the parameters of the tunes. Comparisons of the predictions of the new tunes are provided for observables sensitive to the event shapes at LEP, global underlying event, soft multiparton interactions, and double-parton scattering contributions. In addition, comparisons are made for observables measured in various specific processes, such as multijet, Drell–Yan, and top quark-antiquark pair production including jet substructure observables. The simulation of the underlying event provided by the new tunes is interfaced to a higher-order matrix-element calculation. For the first time, predictions from pythia8 obtained with tunes based on NLO or NNLO PDFs are shown to reliably describe minimum-bias and underlying-event data with a similar level of agreement to predictions from tunes using LO PDF sets.
265 citations
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TL;DR: In this paper, the effect of contact angle hysteresis on the effective disjoining pressure isotherms is also taken into account, and possible explanations of some experimental findings with emulsions stabilized by small adsorbed solid particles are proposed.
265 citations
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TL;DR: In this paper, general expressions for the energy of capillary meniscus forces acting between particles attached to a liquid-fluid interface are derived for the cases of two vertical cylinders and two similar spheres partially immersed in a liquid layer on a horizontal solid substrate.
259 citations
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TL;DR: It is demonstrated that through phosphorylation inputs from both MAPKs and BIN2, SPCH serves as an integration node for stomata and BR signalling pathways to control stomatal development in Arabidopsis.
Abstract: Stomatal formation is regulated by multiple developmental and environmental signals, but how these signals are integrated to control this process is not fully understood. In Arabidopsis thaliana, the basic helix-loop-helix transcription factor SPEECHLESS (SPCH) regulates the entry, amplifying and spacing divisions that occur during stomatal lineage development. SPCH activity is negatively regulated by mitogen-activated protein kinase (MAPK)-mediated phosphorylation. Here, we show that in addition to MAPKs, SPCH activity is also modulated by brassinosteroid (BR) signalling. The GSK3/SHAGGY-like kinase BIN2 (BR INSENSITIVE2) phosphorylates residues overlapping those targeted by the MAPKs, as well as four residues in the amino-terminal region of the protein outside the MAPK target domain. These phosphorylation events antagonize SPCH activity and limit epidermal cell proliferation. Conversely, inhibition of BIN2 activity in vivo stabilizes SPCH and triggers excessive stomatal and non-stomatal cell formation. We demonstrate that through phosphorylation inputs from both MAPKs and BIN2, SPCH serves as an integration node for stomata and BR signalling pathways to control stomatal development in Arabidopsis.
259 citations
Authors
Showing all 8600 results
Name | H-index | Papers | Citations |
---|---|---|---|
Michael Tytgat | 134 | 1449 | 94133 |
Leander Litov | 133 | 1424 | 92713 |
Eric Conte | 132 | 1206 | 84593 |
Georgi Sultanov | 132 | 1493 | 93318 |
Plamen Iaydjiev | 131 | 1285 | 87958 |
Anton Dimitrov | 130 | 1236 | 86919 |
Jordan Damgov | 129 | 1195 | 85490 |
Borislav Pavlov | 129 | 1245 | 86458 |
Jean-Laurent Agram | 128 | 1221 | 84423 |
Cristina Botta | 128 | 1160 | 79070 |
Jean-Charles Fontaine | 128 | 1190 | 84011 |
Peicho Petkov | 128 | 1111 | 83495 |
Muhammad Ahmad | 128 | 1187 | 79758 |
Roumyana Hadjiiska | 126 | 1003 | 73091 |
Mircho Rodozov | 124 | 972 | 70519 |