Sofia University

About: Sofia University is a education organization based out in Sofia, Bulgaria. It is known for research contribution in the topics: Large Hadron Collider & Standard Model. The organization has 8533 authors who have published 15730 publications receiving 306320 citations. The organization is also known as: University of Sofia & BFUS.

Generation of Second-Harmonic Conical Waves via Nonlinear Bragg Diffraction

Abstract: We report on the observation of second-harmonic conical waves generated in a novel geometry of the transverse excitation of an annular periodically poled nonlinear photonic structure by a fundamental Gaussian beam. We show that the conical beams are formed as a result of the higher-order nonlinear Bragg diffraction involving two parametric processes in which an ordinary fundamental wave is converted simultaneously into ordinary and extraordinary polarized second harmonics.

Lack of CpG Island Methylator Phenotype Defines a Clinical Subtype of T-Cell Acute Lymphoblastic Leukemia Associated With Good Prognosis

Abstract: Purpose To examine cancer genes undergoing epigenetic inactivation in a set of T-cell acute lymphoblastic leukemias (T-ALLs) to obtain the CpG island methylator phenotype (CIMP) in the disease and its possible correlation with clinical features and outcome of the patients. Patients and Methods Methylation-specific polymerase chain reaction was used to analyze methylation of the ADAMTS-1, ADAMTS-5, APAF-1, ASPP-1, CDH1, CDH13, DAPK, DIABLO, DKK-3, LATS-1, LATS-2, NES-1, p14, p15, p16, p57, p73, PARK-2, PTEN, sFRP1/2/4/5, SHP-1, SYK, TMS-1, and WIF-1 genes in samples from 50 consecutive T-ALL patients (19 children and 31 adults). Results were compared with results obtained in 286 B-cell acute lymphoblastic leukemias (B-ALLs). Results A total of 88% of the T-ALL samples had at least one gene methylated. According to the number of methylated genes observed in each individual sample, 12 patients (24%) were included in the CIMP− group (zero to two methylated genes), and 38 patients (76%) were included in the CI...