Institution
Sojo University
Education•Kumamoto, Japan•
About: Sojo University is a education organization based out in Kumamoto, Japan. It is known for research contribution in the topics: Human serum albumin & In vivo. The organization has 1034 authors who have published 2001 publications receiving 40050 citations. The organization is also known as: Sōjō daigaku.
Topics: Human serum albumin, In vivo, Glycoside, Oxidative stress, Liposome
Papers published on a yearly basis
Papers
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TL;DR: Molecular mechanisms of factors related to the EPR effect, the unique anatomy of tumor vessels, limitations and techniques to avoid such limitations, augmenting tumor drug delivery, and experimental and clinical findings are discussed.
3,034 citations
TL;DR: A historical review of the EPR effect, including its features, vascular mediators found in both cancer and inflamed tissue, and methods of augmentation of theEPR effect are described, that result in better tumor delivery and improved therapeutic effect.
1,900 citations
TL;DR: Various endogenous factors that can positively impact the EPR effect in tumor tissues are discussed, as well as practical methods available in the clinical setting for augmenting the effect by use of exogenous agents.
1,701 citations
TL;DR: This report summarizes the workshop discussions on key issues of the EPR effect and major gaps that need to be addressed to effectively advance nanoparticle-based drug delivery.
Abstract: Enhanced permeability of the tumor vasculature allows macromolecules to enter the tumor interstitial space, whereas the suppressed lymphatic filtration allows them to stay there. This phenomenon, enhanced permeability and retention (EPR), has been the basis of nanotechnology platforms to deliver drugs to tumors. However, progress in developing effective drugs using this approach has been hampered by heterogeneity of EPR effect in different tumors and limited experimental data from patients on effectiveness of this mechanism as related to enhanced drug accumulation. This report summarizes the workshop discussions on key issues of the EPR effect and major gaps that need to be addressed to effectively advance nanoparticle-based drug delivery.
1,247 citations
TL;DR: The EPR-effect appears as a universal phenomenon in solid tumors which warrants the development of other polymeric drugs or nanomedicine, and then advantages and problems of macromolecular drugs.
1,081 citations
Authors
Showing all 1039 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Hiroshi Maeda | 103 | 893 | 63370 |
| Seiji Shinkai | 103 | 1158 | 48059 |
| Koji Yamada | 71 | 810 | 21893 |
| Masaki Otagiri | 61 | 608 | 17524 |
| Ken Ichi Yamamura | 60 | 275 | 19123 |
| Timothy J. Deming | 58 | 199 | 14177 |
| Kaneto Uekama | 54 | 378 | 15129 |
| Nobuo Kimizuka | 51 | 288 | 8622 |
| Fumitoshi Hirayama | 47 | 281 | 9763 |
| Hirotaka Ihara | 44 | 417 | 7114 |
| Kazuo Sakurai | 42 | 371 | 7530 |
| Arun K. Iyer | 41 | 136 | 7620 |
| Yoshihiro Nakata | 40 | 181 | 5040 |
| John E. Hallsworth | 40 | 101 | 5304 |
| Shintaro Furusaki | 37 | 203 | 4393 |