Institution
Soroka Medical Center
Healthcare•Beersheba, Israel•
About: Soroka Medical Center is a healthcare organization based out in Beersheba, Israel. It is known for research contribution in the topics: Population & Pregnancy. The organization has 1418 authors who have published 1518 publications receiving 37115 citations. The organization is also known as: ha-Merkaz ha-refuʼi ha-universiṭaʼi Soroḳah (Beersheba).
Topics: Population, Pregnancy, Myocardial infarction, Cancer, Diabetes mellitus
Papers published on a yearly basis
Papers
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TL;DR: Nine recommendations for the management of fibromyalgia syndrome were developed using a systematic review and expert consensus using a Delphi process.
Abstract: Objective: To develop evidence-based recommendations for the management of fibromyalgia syndrome. Methods: A multidisciplinary task force was formed representing 11 European countries. The design o ...
759 citations
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TL;DR: Using standardized definitions and training, it is possible to achieve agreement in identifying Radiological pneumonia, thus facilitating the comparison of results of epidemiological studies that use radiological pneumonia as an outcome.
Abstract: BACKGROUND: Although radiological pneumonia is used as an outcome measure in epidemiological studies, there is considerable variability in the interpretation of chest radiographs. A standardized method for identifying radiological pneumonia would facilitate comparison of the results of vaccine trials and epidemiological studies of pneumonia. METHODS: A WHO working group developed definitions for radiological pneumonia. Inter-observer variability in categorizing a set of 222 chest radiographic images was measured by comparing the readings made by 20 radiologists and clinicians with a reference reading. Intra-observer variability was measured by comparing the initial readings of a randomly chosen subset of 100 radiographs with repeat readings made 8-30 days later. FINDINGS: Of the 222 images, 208 were considered interpretable. The reference reading categorized 43% of these images as showing alveolar consolidation or pleural effusion (primary end-point pneumonia); the proportion thus categorized by each of the 20 readers ranged from 8% to 61%. Using the reference reading as the gold standard, 14 of the 20 readers had sensitivity and specificity of > 0.70 in identifying primary end-point pneumonia; 13 out of 20 readers had a kappa index of > 0.6 compared with the reference reading. For the 92 radiographs deemed to be interpretable among the 100 images used for intra-observer variability, 19 out of 20 readers had a kappa index of > 0.6. CONCLUSION: Using standardized definitions and training, it is possible to achieve agreement in identifying radiological pneumonia, thus facilitating the comparison of results of epidemiological studies that use radiological pneumonia as an outcome.
586 citations
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TL;DR: Preerential macrophage infiltration into OM fat is a general phenomenon exaggerated by central obesity, potentially linking central adiposity with increased risk of diabetes and coronary heart disease.
Abstract: Context: Macrophage infiltration into adipose tissue has been demonstrated to accompany obesity, with a potential preferential infiltration into intraabdominal vs. sc fat. Objective: Our objective was to determine whether this occurs across different populations with a range of body mass indexes and to assess the relationship with regional adiposity and comorbidity of obesity. Setting and Patients: In two independent cohorts, we used paired omental (OM) and sc fat biopsies from lean controls or predominantly sc or intraabdominally obese persons with minimal comorbidity (n = 60, cohort 1), or from severely obese women with a significant rate of comorbidity (n = 29, cohort 2). Results: Elevated macrophage infiltration into OM vs. sc fat was observable in lean subjects and exaggerated by obesity, particularly if predominantly intraabdominal. This was paralleled by increased monocyte chemoattractant protein-1 (MCP1) and colony-stimulating factor-1 (CSF1) mRNA levels. Level of CSF1 and MCP1 mRNA correlated wit...
532 citations
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TL;DR: The identification by positional cloning of a new gene, BSND, as the cause of Antenatal Bartter syndrome is reported, which encodes a hitherto unknown protein with two putative transmembrane α-helices that might function as a regulator for ion-transport proteins involved in aBS, or else as a new transporter or channel itself.
Abstract: Antenatal Bartter syndrome (aBS) comprises a heterogeneous group of autosomal recessive salt-losing nephropathies. Identification of three genes that code for renal transporters and channels as responsible for aBS has resulted in new insights into renal salt handling, diuretic action and blood-pressure regulation. A gene locus of a fourth variant of aBS called BSND, which in contrast to the other forms is associated with sensorineural deafness (SND) and renal failure, has been mapped to chromosome 1p. We report here the identification by positional cloning, in a region not covered by the human genome sequencing projects, of a new gene, BSND, as the cause of BSND. We examined ten families with BSND and detected seven different mutations in BSND that probably result in loss of function. In accordance with the phenotype, BSND is expressed in the thin limb and the thick ascending limb of the loop of Henle in the kidney and in the dark cells of the inner ear. The gene encodes a hitherto unknown protein with two putative transmembrane alpha-helices and thus might function as a regulator for ion-transport proteins involved in aBS, or else as a new transporter or channel itself.
475 citations
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TL;DR: In patients with cystic fibrosis who have a premature stop codon in the CFTR gene, oral administration of PTC124 to suppress nonsense mutations reduces the epithelial electrophysiological abnormalities caused by CFTR dysfunction.
412 citations
Authors
Showing all 1425 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gideon Koren | 129 | 1994 | 81718 |
Yehuda Shoenfeld | 125 | 1629 | 77195 |
Moussa B.H. Youdim | 107 | 574 | 42538 |
Maria I. New | 95 | 610 | 29564 |
Ron Dagan | 88 | 632 | 29078 |
Amos D. Korczyn | 80 | 582 | 32820 |
Moshe Mazor | 73 | 448 | 21830 |
John S. Parks | 73 | 329 | 19861 |
Rosalind A. Coleman | 69 | 207 | 15250 |
Moshe Phillip | 66 | 311 | 15215 |
Daniel Talmor | 65 | 270 | 17351 |
Hagit Cohen | 64 | 219 | 13079 |
Dan Atar | 63 | 401 | 57761 |
Ofer Levy | 62 | 360 | 17789 |
Eyal Sheiner | 61 | 655 | 14655 |