Institution
Southeast University
Education•Nanjing, China•
About: Southeast University is a education organization based out in Nanjing, China. It is known for research contribution in the topics: Computer science & MIMO. The organization has 66363 authors who have published 79434 publications receiving 1170576 citations. The organization is also known as: SEU.
Papers published on a yearly basis
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TL;DR: This work found 977 genes that are associated with epilepsy and summarized the epilepsy-associated genes according to their function, with the goal of better characterize the association between genes and epilepsies and to further understand the mechanisms underlying epilepsy.
Abstract: Development in genetic technology has led to the identification of an increasing number of genes associated with epilepsy. These discoveries will both provide the basis for including genetic tests in clinical practice and improve diagnosis and treatment of epilepsy. By searching through several databases (OMIM, HGMD, and EpilepsyGene) and recent publications on PubMed, we found 977 genes that are associated with epilepsy. We classified these genes into 4 categories according to the manifestation of epilepsy in phenotypes. We found 84 genes that are considered as epilepsy genes: genes that cause epilepsies or syndromes with epilepsy as the core symptom. 73 genes were listed as neurodevelopment-associated genes: genes associated with both brain-development malformations and epilepsy. Several genes (536) were epilepsy-related: genes associated with both physical or other systemic abnormalities and epilepsy or seizures. We found 284 additional genes putatively associated with epilepsy; this requires further verification. These integrated data will provide new insights useful for both including genetic tests in the clinical practice and evaluating the results of genetic tests. We also summarized the epilepsy-associated genes according to their function, with the goal to better characterize the association between genes and epilepsies and to further understand the mechanisms underlying epilepsy.
277 citations
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TL;DR: In this paper, the possibility of using iron ore tailings to replace natural aggregate to prepare ultra-high performance concrete (UHPC) under two different curing regimes was investigated, and it was found that 100% replacement of natural aggregate by the tailings significantly decreased the workability and compressive strength of the material.
276 citations
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University of Texas at Arlington1, University of Colorado Denver2, Alberta Children's Hospital3, University of Chicago4, Southeast University5, Linfield College6, Mississippi State University7, University of Utah8, University of Toronto9, Washington University in St. Louis10, Virginia Commonwealth University11, Texas Tech University12, Bangor University13, Leiden University14, Naturalis15, Liverpool School of Tropical Medicine16, University of Northern Colorado17, Iowa State University18, University of Alabama19
TL;DR: The python and king cobra genomes are compared along with genomic samples from other snakes and transcriptome analysis is performed to gain insights into the extreme phenotypes of the python, finding rapid and massive transcriptional responses in multiple organ systems that occur on feeding and coordinate major changes in organ size and function.
Abstract: Snakes possess many extreme morphological and physiological adaptations. Identification of the molecular basis of these traits can provide novel understanding for vertebrate biology and medicine. Here, we study snake biology using the genome sequence of the Burmese python (Python molurus bivittatus), a model of extreme physiological and metabolic adaptation. We compare the python and king cobra genomes along with genomic samples from other snakes and perform transcriptome analysis to gain insights into the extreme phenotypes of the python. We discovered rapid and massive transcriptional responses in multiple organ systems that occur on feeding and coordinate major changes in organ size and function. Intriguingly, the homologs of these genes in humans are associated with metabolism, development, and pathology. We also found that many snake metabolic genes have undergone positive selection, which together with the rapid evolution of mitochondrial proteins, provides evidence for extensive adaptive redesign of snake metabolic pathways. Additional evidence for molecular adaptation and gene family expansions and contractions is associated with major physiological and phenotypic adaptations in snakes; genes involved are related to cell cycle, development, lungs, eyes, heart, intestine, and skeletal structure, including GRB2-associated binding protein 1, SSH, WNT16, and bone morphogenetic protein 7. Finally, changes in repetitive DNA content, guanine-cytosine isochore structure, and nucleotide substitution rates indicate major shifts in the structure and evolution of snake genomes compared with other amniotes. Phenotypic and physiological novelty in snakes seems to be driven by system-wide coordination of protein adaptation, gene expression, and changes in the structure of the genome.
276 citations
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TL;DR: This study provides direct evidence for the association of a great majority of convergent and a minority of divergent connectivity of WM structural networks between RGD and aMCI patients, which may lead to increasing attention in defining a population at risk of AD.
Abstract: Alzheimer's disease (AD) can be conceptualized as a disconnection syndrome. Both remitted geriatric depression (RGD) and amnestic mild cognitive impairment (aMCI) are associated with a high risk for developing AD. However, little is known about the similarities and differences in the topological patterns of white matter (WM) structural networks between RGD and aMCI. In this study, diffusion tensor imaging and deterministic tractography were used to map the human WM networks of 35 RGD patients, 38 aMCI patients, and 30 healthy subjects. Furthermore, graph theoretical methods were applied to investigate the alterations in the global and regional properties of the WM network in these patients. First, both the RGD and aMCI patients showed abnormal global topology in their WM networks (i.e., reduced network strength, reduced global efficiency, and increased absolute path length) compared with the controls, and there were no significant differences in these global network properties between the patient groups. Second, similar deficits of the regional and connectivity characteristics in the WM networks were primarily found in the frontal brain regions of RGD and aMCI patients compared with the controls, while a different nodal efficiency of the posterior cingulate cortex and several prefrontal brain regions were also observed between the patient groups. Together, our study provides direct evidence for the association of a great majority of convergent and a minority of divergent connectivity of WM structural networks between RGD and aMCI patients, which may lead to increasing attention in defining a population at risk of AD.
276 citations
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TL;DR: A hybrid molecular ferroElectric, (pyrrolidinium)MnCl3, is reported, which exhibits excellent ferroelectricity with a saturation polarization of 5.5 μC/cm(2) as well as intense red luminescence with high quantum yield of 56% under a UV excitation, which may extend the application of organic-inorganic hybrid compounds to the field of ferro electric luminescent and/or multifunctional devices.
Abstract: Luminescence of ferroelectric materials is one important property for technological applications, such as low-energy electron excitation. However, the vast majority of doped inorganic ferroelectric materials have low luminescent efficiency. The past decade has envisaged much progress in the design of both ferroelectric and luminescent organic-inorganic hybrid complexes for optoelectronic applications. The combination of ferroelectricity and luminescence within organic-inorganic hybrids would lead to a new type of luminescent ferroelectric multifunctional materials. We herein report a hybrid molecular ferroelectric, (pyrrolidinium)MnCl3, which exhibits excellent ferroelectricity with a saturation polarization of 5.5 μC/cm(2) as well as intense red luminescence with high quantum yield of 56% under a UV excitation. This finding may extend the application of organic-inorganic hybrid compounds to the field of ferroelectric luminescence and/or multifunctional devices.
276 citations
Authors
Showing all 66906 results
Name | H-index | Papers | Citations |
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H. S. Chen | 179 | 2401 | 178529 |
Yang Yang | 171 | 2644 | 153049 |
Gang Chen | 167 | 3372 | 149819 |
Xiang Zhang | 154 | 1733 | 117576 |
Rui Zhang | 151 | 2625 | 107917 |
Yi Yang | 143 | 2456 | 92268 |
Guanrong Chen | 141 | 1652 | 92218 |
Wei Huang | 139 | 2417 | 93522 |
Jun Chen | 136 | 1856 | 77368 |
Jian Li | 133 | 2863 | 87131 |
Xiaoou Tang | 132 | 553 | 94555 |
Zhen Li | 127 | 1712 | 71351 |
Tao Zhang | 123 | 2772 | 83866 |
Bo Wang | 119 | 2905 | 84863 |
Jinde Cao | 117 | 1430 | 57881 |