Institution
Southwest University
Education•Chongqing, China•
About: Southwest University is a education organization based out in Chongqing, China. It is known for research contribution in the topics: Population & Bombyx mori. The organization has 29772 authors who have published 27755 publications receiving 409441 citations. The organization is also known as: Southwest University in Chongqing & SWU.
Topics: Population, Bombyx mori, Gene, Electrochemiluminescence, Biosensor
Papers published on a yearly basis
Papers
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TL;DR: A novel aptasensor is successfully constructed, it provides an efficient way for sensitive AFB1 sensing as well as a new technique for aptamer based novel sensor construction.
197 citations
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TL;DR: It is hopeful that azole compounds may continue to serve as an important direction for the exploitation of azole-based antibacterial and antifungal drugs with better curative effect, lower toxicity, less side effects, especially fewer resistances and so on.
Abstract: Azole compounds are an important class of nitrogen heterocycles with electron-rich property. This special structure endows azole-based derivatives easily bind with the enzymes and receptors in organisms through noncovalent interactions such as hydrogen bonds, coordination bonds, ion-dipole, cation-π,π-π stacking and hydrophobic effect as well as van der Waals force etc., thereby possessing various applications in medicinal chemistry, especially their protrudent effects such as imidazoles and triazoles against fungal strains. The design, synthesis and antimicrobial activity of azole derivatives have been extensively investigated and have become one of the highly active highlights in recent years, and the progress is quite rapid. In particular, a large number of azole-based antibacterial and antifungal agents have been penetratingly studied as candidates and even some of them have been used in clinic, which have shown the great potential and development value of azole compounds. Based on our researches on azole compounds and referring to other literature, this work scientifically reviewed the researches and developments of azole-based compounds as antibacterial and antifungal agents, including oxazole, imidazole, benzimidazole, triazole, benzotriazole, pyrazole, thiazole, carbazole as well as tetrazole in recent three years. It is hopeful that azole compounds may continue to serve as an important direction for the exploitation of azole-based antibacterial and antifungal drugs with better curative effect, lower toxicity, less side effects, especially fewer resistances and so on.
196 citations
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TL;DR: In this article, the authors focus on the long tail of hate speech and propose deep neural network structures serving as feature extractors that are particularly effective for capturing the semantics of the hate speech.
Abstract: In recent years, the increasing propagation of hate speech on social media and the urgent need for effective counter-measures have drawn significant investment from governments, companies, and researchers. A large number of methods have been developed for automated hate speech detection online. This aims to classify textual content into non-hate or hate speech, in which case the method may also identify the targeting characteristics (i.e., types of hate, such as race, and religion) in the hate speech. However, we notice significant difference between the performance of the two (i.e., non-hate v.s. hate). In this work, we argue for a focus on the latter problem for practical reasons. We show that it is a much more challenging task, as our analysis of the language in the typical datasets shows that hate speech lacks unique, discriminative features and therefore is found in the 'long tail' in a dataset that is difficult to discover. We then propose Deep Neural Network structures serving as feature extractors that are particularly effective for capturing the semantics of hate speech. Our methods are evaluated on the largest collection of hate speech datasets based on Twitter, and are shown to be able to outperform the best performing method by up to 5 percentage points in macro-average F1, or 8 percentage points in the more challenging case of identifying hateful content.
196 citations
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TL;DR: The prevalence of depressive symptoms in Chinese older adults presented a downward tendency with increasing educational level, and gradually increased with the year of data collection, which was greater in women than in single adults.
195 citations
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TL;DR: The results suggest that the development of MgONPs as alternative antibacterial agents will become a new research subject.
Abstract: Magnesium (Mg) is an essential mineral element for plants and is nontoxic to organisms. In this study, we took advantage of nanotechnologies to systematically investigate the antibacterial mechanisms of magnesium oxide nanoparticles (MgONPs) against the phytopathogen Ralstonia solanacearum (R. solanacearum) in vitro and in vivo for the first time. R. solanacearum has contributed to catastrophic bacterial wilt, which has resulted in the world-wide reduction of tobacco production. The results demonstrated that MgONPs possessed statistically significant concentration-dependent antibacterial activity, and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were measured as 200 and 250 μg/mL, respectively. Additional studies, aimed at understanding the toxicity mechanism of MgONPs, indicated that physical injury occurred to the cell membranes, along with decreased motility and biofilm formation ability of R. solanacearum, due to the direct attachment of MgONPs to the surfaces of the bacterial cells, which was observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Reactive oxygen species (ROS) accumulation could also be an important reason for the antibacterial action, inducing DNA damage. The toxicity assessment assay under greenhouse conditions demonstrated that the MgONPs had exerted a large effect on tobacco bacterial wilt, reducing the bacterial wilt index. Altogether, the results suggest that the development of MgONPs as alternative antibacterial agents will become a new research subject.
195 citations
Authors
Showing all 29978 results
Name | H-index | Papers | Citations |
---|---|---|---|
Frank B. Hu | 250 | 1675 | 253464 |
Hongjie Dai | 197 | 570 | 182579 |
Jing Wang | 184 | 4046 | 202769 |
Chao Zhang | 127 | 3119 | 84711 |
Jianjun Liu | 112 | 1040 | 71032 |
Miao Liu | 111 | 993 | 59811 |
Jun Yang | 107 | 2090 | 55257 |
Eric Westhof | 98 | 472 | 34825 |
En-Tang Kang | 97 | 763 | 38498 |
Chang Ming Li | 97 | 896 | 42888 |
Wei Zhou | 93 | 1640 | 39772 |
Li Zhang | 92 | 918 | 35648 |
Heinz Rennenberg | 87 | 527 | 26359 |
Tao Chen | 86 | 820 | 27714 |
Xun Wang | 84 | 606 | 32187 |