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Institution

Southwest University

EducationChongqing, China
About: Southwest University is a education organization based out in Chongqing, China. It is known for research contribution in the topics: Population & Bombyx mori. The organization has 29772 authors who have published 27755 publications receiving 409441 citations. The organization is also known as: Southwest University in Chongqing & SWU.


Papers
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Journal ArticleDOI
Cun Wang1, Ruo Yuan1, Yaqin Chai1, Shihong Chen1, Yu Zhang1, Fangxin Hu1, Meihe Zhang1 
TL;DR: In this paper, a modified glassy carbon electrode (GCE) was fabricated and successfully used for the simultaneous determination of ascorbic acid (AA), dopamine (DA), uric acid(UA), and nitrite (NO 2 − ).

134 citations

Journal ArticleDOI
TL;DR: In this paper, it was shown that the generalized second law of thermodynamics holds only in the case where the enveloping surface is the apparent horizon, but not in case of the event horizon.

134 citations

Journal ArticleDOI
TL;DR: Highly efficient and multiplex genome editing in B. mori cell line and heritable site-directed mutagenesis of Bmku70, which is required for NHEJ pathway and also related to antigen diversity, telomere length maintenance and subtelomeric gene silencing, using CRISPR/Cas9 system are reported.
Abstract: CRISPR/Cas9, a bacterial adaptive immune system derived genome-editing technique, has become to be one of the most compelling topics in biotechnology. Bombyx mori is an economically important insect and a model organism for studying lepidopteran and arthropod biology. Here we reported highly efficient and multiplex genome editing in B. mori cell line and heritable site-directed mutagenesis of Bmku70, which is required for NHEJ pathway and also related to antigen diversity, telomere length maintenance and subtelomeric gene silencing, using CRISPR/Cas9 system. We established a simple and practicable method and obtained several Bmku70 knockout B. mori lines, and showed that the frequency of HR was increased in embryos of the Bmku70 knockout B. mori. The mutant lines obtained in this study could be a candidate genetic resource for efficient knock-in and fundamental research of DNA repair in B. mori. We also provided a strategy and procedure to perform heritable genome editing of target genes with no significant phenotype effect.

134 citations

Journal ArticleDOI
TL;DR: Results from peer-reviewed articles published prior to 2017 that address potential human exposures through ingestion and inhalation, as well as results from human biomonitoring studies are summarized and the use of relative potency factor approach is proposed in order to facilitate the assessment of concurrent exposure to a mixture of neonics with similar chemical structures and toxicological endpoints.

134 citations

Journal ArticleDOI
TL;DR: This study shows the promising capability of the co-delivered siCD98 and CUR for boosting the conventional monotherapy via this novel nanotherapeutic agent, which offers a structurally simple platform for orally administered delivery of drugs to target cells in UC therapy.
Abstract: Combination therapy is an emerging strategy that is under intensive preclinical investigation for the treatment of various diseases. CD98 is highly overexpressed on the surfaces of epithelial cells and macrophages in the colon tissue with ulcerative colitis (UC), which is usually associated with mucosal damage and inflammation. We previously proved that CD98 siRNA (siCD98)-induced down-regulation of CD98 in colitis tissue decreased the severity of UC to a certain extent. In an effort to further improve the therapeutic efficacy, we aim to simultaneously deliver siCD98 in combination with a potent anti-inflammatory agent, curcumin (CUR), using hyaluronic acid (HA)-functionalized polymeric nanoparticles (NPs). The resultant spherical HA-siCD98/CUR-NPs are featured by a desirable particle size (∼246 nm) and slightly negative zeta potential (∼-14 mV). The NPs functionalized with HA are able to guide the co-delivery of drugs to the targeted cells related to UC therapy (colonic epithelial cells and macrophages). Compared to either siCD98- or CUR-based monotherapy, co-delivery of siCD98 and CUR by HA-functionalized NPs can exert combinational effects against UC by protecting the mucosal layer and alleviating inflammation both in vitro and in vivo. This study shows the promising capability of the co-delivered siCD98 and CUR for boosting the conventional monotherapy via this novel nanotherapeutic agent, which offers a structurally simple platform for orally administered delivery of drugs to target cells in UC therapy.

133 citations


Authors

Showing all 29978 results

NameH-indexPapersCitations
Frank B. Hu2501675253464
Hongjie Dai197570182579
Jing Wang1844046202769
Chao Zhang127311984711
Jianjun Liu112104071032
Miao Liu11199359811
Jun Yang107209055257
Eric Westhof9847234825
En-Tang Kang9776338498
Chang Ming Li9789642888
Wei Zhou93164039772
Li Zhang9291835648
Heinz Rennenberg8752726359
Tao Chen8682027714
Xun Wang8460632187
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202395
2022461
20213,537
20203,257
20192,923
20182,479