Spanish National Research Council

About: Spanish National Research Council is a government organization based out in Madrid, Spain. It is known for research contribution in the topics: Population & Galaxy. The organization has 79563 authors who have published 220470 publications receiving 7698991 citations. The organization is also known as: CSIC & Consejo Superior de Investigaciones Científicas.

Snail blocks the cell cycle and confers resistance to cell death

Abstract: The Snail zinc-finger transcription factors trigger epithelial-mesenchymal transitions (EMTs), endowing epithelial cells with migratory and invasive properties during both embryonic development and tumor progression. During EMT, Snail provokes the loss of epithelial markers, as well as changes in cell shape and the expression of mesenchymal markers. Here, we show that in addition to inducing dramatic phenotypic alterations, Snail attenuates the cell cycle and confers resistance to cell death induced by the withdrawal of survival factors and by pro-apoptotic signals. Hence, Snail favors changes in cell shape versus cell division, indicating that with respect to oncogenesis, although a deregulation/increase in proliferation is crucial for tumor formation and growth, this may not be so for tumor malignization. Finally, the resistance to cell death conferred by Snail provides a selective advantage to embryonic cells to migrate and colonize distant territories, and to malignant cells to separate from the primary tumor, invade, and form metastasis.

Human capital in growth regressions: how much difference does data quality make? An update and further results

Abstract: We construct estimates of educational attainment for a sample of OECD countries using previously unexploited sources. We follow a heuristic approach to obtain plausible time profiles for attainment levels by removing sharp breaks in the data that seem to reflect changes in classification criteria. We then construct indicators of the information content of our series and a number of previously available data sets and examine their performance in several growth specifications. We find a clear positive correlation between data quality and the size and significance of human capital coefficients in growth regressions. Using an extension of the classical errors in variables model, we construct a set of metaestimates of the coefficient of years of schooling in an aggregate Cobb-Douglas production function. Our results suggest that, after correcting for measurement error bias, the value of this parameter is well above 0.50.

Polarimetric observations of 15 active galactic nuclei at high frequencies: jet kinematics from bimonthly monitoring with the very long baseline array

Abstract: We present total and polarized intensity images of 15 active galactic nuclei obtained with the Very Long Baseline Array at 7 mm wavelength at 17 epochs from 1998 March to 2001 April. At some epochs the images are accompanied by nearly simultaneous polarization measurements at 3 mm, 1.35/0.85 mm, and optical wavelengths. Here we analyze the 7 mm images to define the properties of the jets of two radio galaxies, five BL Lac objects, and eight quasars on angular scales 0.1 mas. We determine the apparent velocities of 106 features in the jets. For many of the features we derive Doppler factors using a new method based on a comparison of the timescale of decline in flux density with the light-travel time across the emitting region. This allows us to estimate the Lorentz factors (Γ), intrinsic brightness temperatures, and viewing angles of 73 superluminal knots, as well as the opening angle of the jet for each source. The Lorentz factors of the jet flows in the different blazars range from Γ ~ 5 to 40 with the majority of the quasar components having Γ ~ 16–18, while the values in the BL Lac objects are more uniformly distributed. The brightest knots in the quasars have the highest apparent speeds, while the more slowly moving components are pronounced in the BL Lac objects. The quasars in our sample have similar opening angles and marginally smaller viewing angles than the BL Lacs. The two radio galaxies have lower Lorentz factors and wider viewing angles than the blazars. Opening angle and Lorentz factor are inversely proportional, as predicted by gasdynamical models. The brightness temperature drops more abruptly with distance from the core in the BL Lac objects than in the quasars and radio galaxies, perhaps owing to stronger magnetic fields in the former resulting in more severe synchrotron losses of the highest energy electrons. In nine sources we detect statistically meaningful deviations from ballistic motion, with the majority of components accelerating with distance from the core. In six sources we identify jet features with characteristics of trailing shocks that form behind the primary strong perturbations in jet simulations. The apparent speeds of these components increase with distance from the core, suggestive of acceleration of the underlying jet.