Institution
Spanish National Research Council
Government•Madrid, Spain•
About: Spanish National Research Council is a government organization based out in Madrid, Spain. It is known for research contribution in the topics: Population & Galaxy. The organization has 79563 authors who have published 220470 publications receiving 7698991 citations. The organization is also known as: CSIC & Consejo Superior de Investigaciones Científicas.
Topics: Population, Galaxy, Catalysis, Stars, Star formation
Papers published on a yearly basis
Papers
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TL;DR: Gut microbiota composition is related to body weight, weight gain and metabolic biomarkers during pregnancy, which might be of relevance to the management of the health of women and infants.
Abstract: Obesity is associated with complications during pregnancy and increased health risks in the newborn. The objective of the present study was to establish possible relationships between gut microbiota, body weight, weight gain and biochemical parameters in pregnant women. Fifty pregnant women were classified according to their BMI in normal-weight (n 34) and overweight (n 16) groups. Gut microbiota composition was analysed by quantitative real-time PCR in faeces and biochemical parameters in plasma at 24 weeks of pregnancy. Reduced numbers of Bifidobacterium and Bacteroides and increased numbers of Staphylococcus, Enterobacteriaceae and Escherichia coli were detected in overweight compared with normal-weight pregnant women. E. coli numbers were higher in women with excessive weight gain than in women with normal weight gain during pregnancy, while Bifidobacterium and Akkermansia muciniphila showed an opposite trend. In the whole population, increased total bacteria and Staphylococcus numbers were related to increased plasma cholesterol levels. Increased Bacteroides numbers were related to increased HDL-cholesterol and folic acid levels, and reduced TAG levels. Increased Bifidobacterium numbers were related to increased folic acid levels. Increased Enterobacteriaceae and E. coli numbers were related to increased ferritin and reduced transferrin, while Bifidobacterium levels showed the opposite trend. Therefore, gut microbiota composition is related to body weight, weight gain and metabolic biomarkers during pregnancy, which might be of relevance to the management of the health of women and infants.
719 citations
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TL;DR: This study constitutes a unique DNA methylation analysis of the extreme points of human life at a single-nucleotide resolution level and demonstrated DNA methylomes in the crossroad between the newborn and the nonagenarian/centenarian groups.
Abstract: Human aging cannot be fully understood in terms of the constrained genetic setting. Epigenetic drift is an alternative means of explaining age-associated alterations. To address this issue, we performed whole-genome bisulfite sequencing (WGBS) of newborn and centenarian genomes. The centenarian DNA had a lower DNA methylation content and a reduced correlation in the methylation status of neighboring cytosine—phosphate—guanine (CpGs) throughout the genome in comparison with the more homogeneously methylated newborn DNA. The more hypomethylated CpGs observed in the centenarian DNA compared with the neonate covered all genomic compartments, such as promoters, exonic, intronic, and intergenic regions. For regulatory regions, the most hypomethylated sequences in the centenarian DNA were present mainly at CpG-poor promoters and in tissue-specific genes, whereas a greater level of DNA methylation was observed in CpG island promoters. We extended the study to a larger cohort of newborn and nonagenarian samples using a 450,000 CpG-site DNA methylation microarray that reinforced the observation of more hypomethylated DNA sequences in the advanced age group. WGBS and 450,000 analyses of middle-age individuals demonstrated DNA methylomes in the crossroad between the newborn and the nonagenarian/centenarian groups. Our study constitutes a unique DNA methylation analysis of the extreme points of human life at a single-nucleotide resolution level.
718 citations
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TL;DR: The first crop chosen to parameterize and test the new FAO AquaCrop model is maize (Zea mays L.). Working mainly with data sets from 6 yr of maize field experiments at Davis, CA, plus another 4 yr of Davis maize canopy data, a set of conservative (nearly constant) parameters, presumably applicable to widely different conditions and not specific to a given crop cultivar, was evaluated by test simulations, and used to simulate the 6 yr Davis data as discussed by the authors.
Abstract: The first crop chosen to parameterize and test the new FAO AquaCrop model is maize (Zea mays L.). Working mainly with data sets from 6 yr of maize field experiments at Davis, CA, plus another 4 yr of Davis maize canopy data, a set of conservative (nearly constant) parameters of AquaCrop, presumably applicable to widely different conditions and not specific to a given crop cultivar, was evaluated by test simulations, and used to simulate the 6 yr of Davis data. The treatment variable was irrigation―withholding water after planting continuously, only up to tasseling, from tasseling onward, or intermittently, and with full irrigation (FI) as the control. From year to year, plant density (7―11.9 plants m ―2 ), planting date (14 May―15 June), cultivar (a total of four), and atmospheric evaporative demand varied. The conservative parameters included: canopy growth and canopy decline coefficient (CDC); crop coefficient for transpiration (Tr) at full canopy; normalized water productivity for biomass (WP * ); soil water depletion thresholds for the inhibition leaf growth and of stomatal conductance, and for the acceleration of canopy senescence; reference harvest index (HI o ); and coefficients for adjusting harvest index (HI) in relation to inhibition of leaf growth and of stomatal conductance. With all 19 parameters held constant, AquaCrop simulated the final aboveground biomass within 10% of the measured value for at least 8 of the 13 treatments (6 yr of experiments) and also the grain yield for at least five of the cases. In at least four of the cases, the simulated results were within 5% of the measured for biomass as well as for grain yield. The largest deviation between the simulated and measured values was 22% for biomass, and 24% for grain yield. Importantly, the simulated pattern of canopy progression and biomass accumulation over time were close to those measured, with Willmott's index of agreement (d) for 11 of the 13 cases being ≥0.98 for canopy cover (CC), and ≥0.97 for biomass. Accelerated senescence of canopy due to water stress, however, proved to be dif- ficult to simulate accurately; of the six cases, the index of agreement for the worst one was 0.957 for canopy and 0.915 for biomass. Possible reasons for the discrepancies between the simulated and measured results include simplifications in the model and inaccuracies in measurements. The usefulness of AquaCrop with well-calibrated conservative parameters in assessing water use efficiency (WUE) of a crops under different conditions and in devising strategies to improve WUE is discussed.
718 citations
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TL;DR: In this paper, the authors present multiple lines of evidence suggesting that this cooling may be due to a reduction in the AMOC over the twentieth century and particularly after 1970, and discuss a possible contribution of the melting of the Greenland Ice Sheet to the slowdown.
Abstract: Possible changes in Atlantic meridional overturning circulation (AMOC) provide a key source of uncertainty regarding future climate change. Maps of temperature trends over the twentieth century show a conspicuous region of cooling in the northern Atlantic. Here we present multiple lines of evidence suggesting that this cooling may be due to a reduction in the AMOC over the twentieth century and particularly after 1970. Since 1990 the AMOC seems to have partly recovered. This time evolution is consistently suggested by an AMOC index based on sea surface temperatures, by the hemispheric temperature difference, by coral-based proxies and by oceanic measurements. We discuss a possible contribution of the melting of the Greenland Ice Sheet to the slowdown. Using a multi-proxy temperature reconstruction for the AMOC index suggests that the AMOC weakness after 1975 is an unprecedented event in the past millennium (p > 0.99). Further melting of Greenland in the coming decades could contribute to further weakening of the AMOC.
717 citations
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Vrije Universiteit Brussel1, Pierre-and-Marie-Curie University2, Université libre de Bruxelles3, University of Arizona4, Université catholique de Louvain5, École Normale Supérieure6, Katholieke Universiteit Leuven7, Spanish National Research Council8, University of Paris9, University of Bremen10, Centre national de la recherche scientifique11, Kyoto University12, University of Western Brittany13, French Alternative Energies and Atomic Energy Commission14
TL;DR: It is found that environmental factors are incomplete predictors of community structure and associations across plankton functional types and phylogenetic groups to be nonrandomly distributed on the network and driven by both local and global patterns.
Abstract: Species interaction networks are shaped by abiotic and biotic factors. Here, as part of the Tara Oceans project, we studied the photic zone interactome using environmental factors and organismal abundance profiles and found that environmental factors are incomplete predictors of community structure. We found associations across plankton functional types and phylogenetic groups to be nonrandomly distributed on the network and driven by both local and global patterns. We identified interactions among grazers, primary producers, viruses, and (mainly parasitic) symbionts and validated network-generated hypotheses using microscopy to confirm symbiotic relationships. We have thus provided a resource to support further research on ocean food webs and integrating biological components into ocean models.
717 citations
Authors
Showing all 79686 results
Name | H-index | Papers | Citations |
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Guido Kroemer | 236 | 1404 | 246571 |
George Efstathiou | 187 | 637 | 156228 |
Peidong Yang | 183 | 562 | 144351 |
H. S. Chen | 179 | 2401 | 178529 |
David R. Williams | 178 | 2034 | 138789 |
Andrea Bocci | 172 | 2402 | 176461 |
Adrian L. Harris | 170 | 1084 | 120365 |
Gang Chen | 167 | 3372 | 149819 |
Gregory J. Hannon | 165 | 421 | 140456 |
Alvaro Pascual-Leone | 165 | 969 | 98251 |
Jorge E. Cortes | 163 | 2784 | 124154 |
Dongyuan Zhao | 160 | 872 | 106451 |
John B. Goodenough | 151 | 1064 | 113741 |
David D'Enterria | 150 | 1592 | 116210 |
A. Gomes | 150 | 1862 | 113951 |