Institution
Spanish National Research Council
Government•Madrid, Spain•
About: Spanish National Research Council is a government organization based out in Madrid, Spain. It is known for research contribution in the topics: Population & Galaxy. The organization has 79563 authors who have published 220470 publications receiving 7698991 citations. The organization is also known as: CSIC & Consejo Superior de Investigaciones Científicas.
Topics: Population, Galaxy, Catalysis, Stars, Star formation
Papers published on a yearly basis
Papers
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TL;DR: This research finds that Rab11a regulates apical traffic and lumen formation through the Rab guanine nucleotide exchange factor (GEF), Rabin8, and its target, Rab8a, and reveals an interaction between the machineries of vesicular transport and polarization.
Abstract: To form epithelial organs cells must polarize and generate de novo an apical domain and lumen. Epithelial polarization is regulated by polarity complexes that are hypothesized to direct downstream events, such as polarized membrane traffic, although this interconnection is not well understood. We have found that Rab11a regulates apical traffic and lumen formation through the Rab guanine nucleotide exchange factor (GEF), Rabin8, and its target, Rab8a. Rab8a and Rab11a function through the exocyst to target Par3 to the apical surface, and control apical Cdc42 activation through the Cdc42 GEF, Tuba. These components assemble at a transient apical membrane initiation site to form the lumen. This Rab11a-directed network directs Cdc42-dependent apical exocytosis during lumen formation, revealing an interaction between the machineries of vesicular transport and polarization.
555 citations
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TL;DR: It is argued here that predictable anthropogenic food subsidies (PAFS) provided historically by humans to animals has shaped many communities and ecosystems as the authors see them nowadays and comparison of subsidised and non-subsidised ecosystems can help predict changes in diversity and the related ecosystem services that have suffered the impact of other global change agents.
Abstract: Human activities are the main current driver of global change. From hunter-gatherers through to Neolithic societies–and particularly in contemporary industrialised countries–humans have (voluntarily or involuntarily) provided other animals with food, often with a high spatio-temporal predictability. Nowadays, as much as 30–40% of all food produced in Earth is wasted. We argue here that predictable anthropogenic food subsidies (PAFS) provided historically by humans to animals has shaped many communities and ecosystems as we see them nowadays. PAFS improve individual fitness triggering population increases of opportunistic species, which may affect communities, food webs and ecosystems by altering processes such as competition, predator–prey interactions and nutrient transfer between biotopes and ecosystems. We also show that PAFS decrease temporal population variability, increase resilience of opportunistic species and reduce community diversity. Recent environmental policies, such as the regulation of dumps or the ban of fishing discards, constitute natural experiments that should improve our understanding of the role of food supply in a range of ecological and evolutionary processes at the ecosystem level. Comparison of subsidised and non-subsidised ecosystems can help predict changes in diversity and the related ecosystem services that have suffered the impact of other global change agents.
554 citations
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TL;DR: This version of GeneCodis has been made to remove noisy and redundant output from the enrichment results with the inclusion of a recently reported algorithm that summarizes significantly enriched terms and generates functionally coherent modules of genes and terms.
Abstract: Since its first release in 2007, GeneCodis has become a valuable tool to functionally interpret results from experimental techniques in genomics. This web-based application integrates different sources of information to finding groups of genes with similar biological meaning. This process, known as enrichment analysis, is essential in the interpretation of high-throughput experiments. The frequent feedbacks and the natural evolution of genomics and bioinformatics have allowed the growth of the tool and the development of this third release. In this version, a special effort has been made to remove noisy and redundant output from the enrichment results with the inclusion of a recently reported algorithm that summarizes significantly enriched terms and generates functionally coherent modules of genes and terms. A new comparative analysis has been added to allow the differential analysis of gene sets. To expand the scope of the application, new sources of biological information have been included, such as genetic diseases, drugs–genes interactions and Pubmed information among others. Finally, the graphic section has been renewed with the inclusion of new interactive graphics and filtering options. The application is freely available at http://genecodis.cnb.csic.es.
554 citations
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University of Paris-Sud1, University of Louisville2, Pierre-and-Marie-Curie University3, University of Bonn4, University of Zurich5, University of Manchester6, University of Warwick7, Aix-Marseille University8, Karlsruhe Institute of Technology9, Wayne State University10, Niigata University11, Nara Women's University12, University of Cambridge13, Ludwig Maximilian University of Munich14, Chinese Academy of Sciences15, University of Bristol16, Jožef Stefan Institute17, Spanish National Research Council18, Imperial College London19, University of Milano-Bicocca20, CERN21, University of Victoria22, École Polytechnique Fédérale de Lausanne23, University of Cincinnati24, Novosibirsk State University25, Budker Institute of Nuclear Physics26, Fermilab27, Graduate University for Advanced Studies28, KEK29, University of Melbourne30, Indiana University31, University of Florida32, University of Ljubljana33
TL;DR: In this article, the authors report world averages of measurements of b-hadron, c-, c-, and tau-lepton properties obtained by the Heavy Flavor Averaging Group (HFAG) using results available through the end of 2011.
Abstract: This article reports world averages of measurements of b-hadron, c-hadron, and tau-lepton properties obtained by the Heavy Flavor Averaging Group (HFAG) using results available through the end of 2011. In some cases results available in the early part of 2012 are included. For the averaging, common input parameters used in the various analyses are adjusted (rescaled) to common values, and known correlations are taken into account. The averages include branching fractions, lifetimes, neutral meson mixing parameters, CP violation parameters, parameters of semileptonic decays and CKM matrix elements.
554 citations
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01 May 2012TL;DR: A review of the various plausible explanations that have been proposed for the phenomenon can be found in this article, where a positive feedback loop between local inflammation in adipose tissue and altered immune response in obesity, both contributing to the development of related metabolic complications.
Abstract: Obesity shares with most chronic diseases the presence of an inflammatory component, which accounts for the development of metabolic disease and other associated health alterations. This inflammatory state is reflected in increased circulating levels of pro-inflammatory proteins, and it occurs not only in adults but also in adolescents and children. The chronic inflammatory response has its origin in the links existing between the adipose tissue and the immune system. Obesity, like other states of malnutrition, is known to impair the immune function, altering leucocyte counts as well as cell-mediated immune responses. In addition, evidence has arisen that an altered immune function contributes to the pathogenesis of obesity. This review attempts to briefly comment on the various plausible explanations that have been proposed for the phenomenon: (1) the obesity-associated increase in the production of leptin (pro-inflammatory) and the reduction in adiponectin (anti-inflammatory) seem to affect the activation of immune cells; (2) NEFA can induce inflammation through various mechanisms (such as modulation of adipokine production or activation of Toll-like receptors); (3) nutrient excess and adipocyte expansion trigger endoplasmic reticulum stress; and (4) hypoxia occurring in hypertrophied adipose tissue stimulates the expression of inflammatory genes and activates immune cells. Interestingly, data suggest a greater impact of visceral adipose tissue and central obesity, rather than total body fat, on the inflammatory process. In summary, there is a positive feedback loop between local inflammation in adipose tissue and altered immune response in obesity, both contributing to the development of related metabolic complications.
554 citations
Authors
Showing all 79686 results
Name | H-index | Papers | Citations |
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Guido Kroemer | 236 | 1404 | 246571 |
George Efstathiou | 187 | 637 | 156228 |
Peidong Yang | 183 | 562 | 144351 |
H. S. Chen | 179 | 2401 | 178529 |
David R. Williams | 178 | 2034 | 138789 |
Andrea Bocci | 172 | 2402 | 176461 |
Adrian L. Harris | 170 | 1084 | 120365 |
Gang Chen | 167 | 3372 | 149819 |
Gregory J. Hannon | 165 | 421 | 140456 |
Alvaro Pascual-Leone | 165 | 969 | 98251 |
Jorge E. Cortes | 163 | 2784 | 124154 |
Dongyuan Zhao | 160 | 872 | 106451 |
John B. Goodenough | 151 | 1064 | 113741 |
David D'Enterria | 150 | 1592 | 116210 |
A. Gomes | 150 | 1862 | 113951 |