Spanish National Research Council

About: Spanish National Research Council is a government organization based out in Madrid, Spain. It is known for research contribution in the topics: Population & Galaxy. The organization has 79563 authors who have published 220470 publications receiving 7698991 citations. The organization is also known as: CSIC & Consejo Superior de Investigaciones Científicas.

Mitochondrial glutathione, a key survival antioxidant.

Abstract: Mitochondria are the primary intracellular site of oxygen consumption and the major source of reactive oxygen species (ROS), most of them originating from the mitochondrial respiratory chain Among the arsenal of antioxidants and detoxifying enzymes existing in mitochondria, mitochondrial glutathione (mGSH) emerges as the main line of defense for the maintenance of the appropriate mitochondrial redox environment to avoid or repair oxidative modifications leading to mitochondrial dysfunction and cell death mGSH importance is based not only on its abundance, but also on its versatility to counteract hydrogen peroxide, lipid hydroperoxides, or xenobiotics, mainly as a cofactor of enzymes such as glutathione peroxidase or glutathione-S-transferase (GST) Many death-inducing stimuli interact with mitochondria, causing oxidative stress; in addition, numerous pathologies are characterized by a consistent decrease in mGSH levels, which may sensitize to additional insults From the evaluation of mGSH inf

A Survey of z > 5.7 Quasars in the Sloan Digital Sky Survey. II. Discovery of Three Additional Quasars at z > 6

Abstract: We present the discovery of three new quasars at z > 6 in ~ 1300 deg2 of Sloan Digital Sky Survey imaging data, J114816.64+525150.3 (z = 6.43), J104845.05+463718.3 (z = 6.23), and J163033.90+401209.6 (z = 6.05). The first two objects have weak Lyα emission lines; their redshifts are determined from the positions of the Lyman break. They are only accurate to ~0.05 and could be affected by the presence of broad absorption line systems. The last object has a Lyα strength more typical of lower redshift quasars. Based on a sample of six quasars at z > 5.7 that cover 2870 deg2 presented in this paper and in Paper I, we estimate the comoving density of luminous quasars at z ~ 6 and M1450 5.7 quasars and high-resolution, ground-based images (seeing ~04) of three additional z > 5.7 quasars show that none of them is gravitationally lensed. The luminosity distribution of the high-redshift quasar sample suggests the bright-end slope of the quasar luminosity function at z ~ 6 is shallower than Ψ ∝ L-3.5 (2 σ), consistent with the absence of strongly lensed objects.

Planck 2015 results: XIV. Dark energy and modified gravity

Abstract: We study the implications of Planck data for models of dark energy (DE) and modified gravity (MG) beyond the standard cosmological constant scenario. We start with cases where the DE only directly affects the background evolution, considering Taylor expansions of the equation of state w(a), as well as principal component analysis and parameterizations related to the potential of a minimally coupled DE scalar field. When estimating the density of DE at early times, we significantly improve present constraints and find that it has to be below ~2% (at 95% confidence) of the critical density, even when forced to play a role for z < 50 only. We then move to general parameterizations of the DE or MG perturbations that encompass both effective field theories and the phenomenology of gravitational potentials in MG models. Lastly, we test a range of specific models, such as k-essence, f(R) theories, and coupled DE. In addition to the latest Planck data, for our main analyses, we use background constraints from baryonic acoustic oscillations, type-Ia supernovae, and local measurements of the Hubble constant. We further show the impact of measurements of the cosmological perturbations, such as redshift-space distortions and weak gravitational lensing. These additional probes are important tools for testing MG models and for breaking degeneracies that are still present in the combination of Planck and background data sets. All results that include only background parameterizations (expansion of the equation of state, early DE, general potentials in minimally-coupled scalar fields or principal component analysis) are in agreement with ΛCDM. When testing models that also change perturbations (even when the background is fixed to ΛCDM), some tensions appear in a few scenarios: the maximum one found is ~2σ for Planck TT+lowP when parameterizing observables related to the gravitational potentials with a chosen time dependence; the tension increases to, at most, 3σ when external data sets are included. It however disappears when including CMB lensing.

Role of tau protein in both physiological and pathological conditions.

Abstract: Avila, Jesus, Jose J. Lucas, Mar Perez, and Felix Hernandez. Role of Tau Protein in Both Physiological and Pathological Conditions. Physiol Rev 84: 361–384, 2004; 10.1152/physrev.00024.2003.—The mo...

Comparative organization of chloroplast, mitochondrial and nuclear diversity in plant populations.

Abstract: Plants offer excellent models to investigate how gene flow shapes the organization of genetic diversity. Their three genomes can have different modes of transmission and will hence experience varying levels of gene flow. We have compiled studies of genetic structure based on chloroplast DNA (cpDNA), mitochondrial DNA (mtDNA) and nuclear markers in seed plants. Based on a data set of 183 species belonging to 103 genera and 52 families, we show that the precision of estimates of genetic differentiation ( G ST ) used to infer gene flow is mostly constrained by the sampling of populations. Mode of inheritance appears to have a major effect on G ST . Maternally inherited genomes experience considerably more subdivision (median value of 0.67) than paternally or biparentally inherited genomes ( ∼ 0.10). G ST at cpDNA and mtDNA markers covary narrowly when both genomes are maternally inherited, whereas G ST at paternally and biparentally inherited markers also covary positively but more loosely and G ST at maternally inherited markers are largely independent of values based on nuclear markers. A model-based gross estimate suggests that, at the rangewide scale, historical levels of pollen flow are generally at least an order of magnitude larger than levels of seed flow (median of the pollen-to-seed migration ratio: 17) and that pollen and seed gene flow vary independently across species. Finally, we show that measures of subdivision that take into account the degree of similarity between haplotypes ( N ST or R ST ) make better use of the information inherent in haplotype data than standard measures based on allele frequencies only.