Institution
St Bartholomew's Hospital
Healthcare•London, United Kingdom•
About: St Bartholomew's Hospital is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Cancer. The organization has 11054 authors who have published 13229 publications receiving 501102 citations. The organization is also known as: St. Bartholomew's Hospital & The Royal Hospital of St Bartholomew.
Topics: Population, Cancer, Pregnancy, Diabetes mellitus, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: Blood samples were obtained from 31 consecutive brain-stem-dead (BSD) donors referred to one transplant coordinator during a 9-month period and levels of prolactin, growth hormone, gonadotrophins, and gonadal steroids were variable, but only a minority were frankly deficient in these hormones.
Abstract: Blood samples were obtained, at the time of organ donation, from 31 consecutive brain-stem-dead (BSD) donors referred to one transplant coordinator during a 9-month period. Twenty-four cases (77%) had clinical diabetes insipidus (DI), which was poorly controlled with marked dehydration in a majority of cases (serum osmolality range 268-357; median 302 mOSM/kg). Serum triiodothyronine (T3) was subnormal in 25 (81%); all had normal or high serum reverse T3; and the serum free thyroxine (T4) index was subnormal in 9 (29%), and TSH was subnormal in 7 (23%). In no case were T4 and TSH both subnormal and results were typical of the sick euthyroid syndrome rather than TSH deficiency. Of 21 cases not receiving corticosteroids, 5 (24%) had a serum cortisol above 550 nmol/L (20 micrograms/dl), excluding ACTH deficiency, and only 1 had undetectable cortisol levels. Those with severe hypotension did not have significantly lower serum cortisol (mean 354 vs. 416; P greater than 0.5). Levels of prolactin, growth hormone, gonadotrophins, and gonadal steroids were variable, but only a minority were frankly deficient in these hormones. BSD donors frequently have DI, which is often managed poorly by nonspecialists and requires appropriate replacement therapy. In contrast most patients are not totally deficient in anterior pituitary hormones. Routine hormonal therapy with cortisol and T3 cannot, therefore, be justified on endocrinological grounds. Widespread introduction of such treatment should only follow controlled trials that clearly demonstrate clinically significant improvement in the transplanted organ function, without detriment to the donor.
172 citations
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TL;DR: Three cases of aorto‐enteric fistula which have been treated successfully by resection of the aortic aneurysm are described and it is felt that urgent assessment and early corrective surgery is the only treatment which offers a reasonable chance of survival.
Abstract: Three cases of aorto-enteric fistula which have been treated successfully by resection of the aortic aneurysm are described. Only 5 other successful cases have been reported. One hundred and thirty-one cases are reviewed and analysed, and though more than half of these survived for 24 hours or longer after the first gastro-intestinal haemorrhage, no untreated long-term survival has been recorded. We feel that urgent assessment and early corrective surgery is the only treatment which offers a reasonable chance of survival.
172 citations
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TL;DR: Normal menses were established in the five women who discontinued oral contraceptives at the end of MVPP therapy, and one of them is now pregnant.
171 citations
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Claude Bernard University Lyon 11, Netherlands Cancer Institute2, Harvard University3, University of Würzburg4, University of British Columbia5, University of Kiel6, St Bartholomew's Hospital7, Karolinska Institutet8, University of Barcelona9, Paris Descartes University10, Saarland University11, Stanford University12, Radboud University Nijmegen13
TL;DR: It is demonstrated that the IPI remains the best available index in patients with DLBCL treated with rituximab and chemotherapy with improved discrimination of low-risk patients.
171 citations
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TL;DR: The metabolic benefits underlying UC deregulation in cancer and the relevance of these alterations for cancer diagnosis and therapy are discussed and insight is provided into the metabolic advantages and therapeutic opportunities stemming from urea cycle enzyme perturbations in cancer.
Abstract: Cancer cells reprogramme metabolism to maximize the use of nitrogen and carbon for the anabolic synthesis of macromolecules that are required during tumour proliferation and growth. To achieve this aim, one strategy is to reduce catabolism and nitrogen disposal. The urea cycle (UC) in the liver is the main metabolic pathway to convert excess nitrogen into disposable urea. Outside the liver, UC enzymes are differentially expressed, enabling the use of nitrogen for the synthesis of UC intermediates that are required to accommodate cellular needs. Interestingly, the expression of UC enzymes is altered in cancer, revealing a revolutionary mechanism to maximize nitrogen incorporation into biomass. In this Review, we discuss the metabolic benefits underlying UC deregulation in cancer and the relevance of these alterations for cancer diagnosis and therapy.
170 citations
Authors
Showing all 11065 results
Name | H-index | Papers | Citations |
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Philippe Froguel | 166 | 820 | 118816 |
Geoffrey Burnstock | 141 | 1488 | 99525 |
Michael A. Kamm | 124 | 637 | 53606 |
David Scott | 124 | 1561 | 82554 |
Csaba Szabó | 123 | 958 | 61791 |
Roger Williams | 122 | 1455 | 72416 |
Derek M. Yellon | 122 | 638 | 54319 |
Walter F. Bodmer | 121 | 579 | 68679 |
John E. Deanfield | 120 | 497 | 61067 |
Paul Bebbington | 119 | 583 | 46341 |
William C. Sessa | 117 | 383 | 52208 |
Timothy G. Dinan | 116 | 689 | 60561 |
Bruce A.J. Ponder | 116 | 403 | 54796 |
Alexandra J. Lansky | 114 | 632 | 54445 |
Glyn Lewis | 113 | 734 | 49316 |