Institution
St Bartholomew's Hospital
Healthcare•London, United Kingdom•
About: St Bartholomew's Hospital is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Cancer. The organization has 11054 authors who have published 13229 publications receiving 501102 citations. The organization is also known as: St. Bartholomew's Hospital & The Royal Hospital of St Bartholomew.
Topics: Population, Cancer, Transplantation, Diabetes mellitus, Pregnancy
Papers published on a yearly basis
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TL;DR: More doctors supported a 24-week legal limit to abortion than were willing themselves to perform late abortions except for fetal abnormality or risk to a woman's life.
611 citations
TL;DR: Comprehensive screening of glycation adducts revealed the relative and quantitative importance of alpha-oxoaldehyde-derived advanced glycation endproducts in physiological modification of proteins-particularly hydroimidazolones, the efficient renal clearance of freeAdducts, and the marked increases in glycationadducts in diabetes and uraemia.
Abstract: Glycation of proteins forms fructosamines and advanced glycation endproducts. Glycation adducts may be risk markers and risk factors of disease development. We measured the concentrations of the early glycation adduct fructosyl-lysine and 12 advanced glycation endproducts by liquid chromatography with tandem mass spectrometric detection. Underivatized analytes were detected free in physiological fluids and in enzymic hydrolysates of cellular and extracellular proteins. Hydroimidazolones were the most important glycation biomarkers quantitatively; monolysyl adducts (N(epsilon)-carboxymethyl-lysine and N(epsilon)-1-carboxyethyl-lysine) were found in moderate amounts, and bis(lysyl)imidazolium cross-links and pentosidine in lowest amounts. Quantitative screening showed high levels of advanced glycation endproducts in cellular protein and moderate levels in protein of blood plasma. Glycation adduct accumulation in tissues depended on the particular adduct and tissue type. Low levels of free advanced glycation endproducts were found in blood plasma and levels were 10-100-fold higher in urine. Advanced glycation endproduct residues were increased in blood plasma and at sites of vascular complications development in experimental diabetes; renal glomeruli, retina and peripheral nerve. In clinical uraemia, the concentrations of plasma protein advanced glycation endproduct residues increased 1-7-fold and free adduct concentrations increased up to 50-fold. Comprehensive screening of glycation adducts revealed the relative and quantitative importance of alpha-oxoaldehyde-derived advanced glycation endproducts in physiological modification of proteins-particularly hydroimidazolones, the efficient renal clearance of free adducts, and the marked increases of glycation adducts in diabetes and uraemia-particularly free advanced glycation endproducts in uraemia. Increased levels of these advanced glycation endproducts were associated with vascular complications in diabetes and uraemia.
604 citations
Erasmus University Rotterdam1, University of Tennessee2, St Bartholomew's Hospital3, University of Michigan4, Harvard University5, Cedars-Sinai Medical Center6, University of Virginia7, Columbia University8, Queen Elizabeth Hospital Birmingham9, University of Texas MD Anderson Cancer Center10, University of North Carolina at Chapel Hill11, Sahlgrenska University Hospital12, New York University13, Oregon Health & Science University14, Emory University15, Ludwig Maximilian University of Munich16
TL;DR: Pegvisomant is an effective medical treatment for acromegaly and of the patients treated for 12 months or more, 87 of 90 (97%) achieved a normal serum IGF-1 concentration.
601 citations
TL;DR: Age, late presentation, and rheumatoid factor seropositivity at presentation were poor prognostic factors, and the concept of "remission-inducing" drugs is fallacious.
583 citations
TL;DR: Ghrelin is a brain-gut peptide with growth hormone-releasing and appetite-inducing activities as mentioned in this paper, which is mainly secreted from the stomach mucosa but it is also expressed widely in different tissues and therefore may have both endocrine and paracrine effects.
580 citations
Authors
Showing all 11065 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Philippe Froguel | 166 | 820 | 118816 |
| Geoffrey Burnstock | 141 | 1488 | 99525 |
| Michael A. Kamm | 124 | 637 | 53606 |
| David Scott | 124 | 1561 | 82554 |
| Csaba Szabó | 123 | 958 | 61791 |
| Roger Williams | 122 | 1455 | 72416 |
| Derek M. Yellon | 122 | 638 | 54319 |
| Walter F. Bodmer | 121 | 579 | 68679 |
| John E. Deanfield | 120 | 497 | 61067 |
| Paul Bebbington | 119 | 583 | 46341 |
| William C. Sessa | 117 | 383 | 52208 |
| Timothy G. Dinan | 116 | 689 | 60561 |
| Bruce A.J. Ponder | 116 | 403 | 54796 |
| Alexandra J. Lansky | 114 | 632 | 54445 |
| Glyn Lewis | 113 | 734 | 49316 |