Institution
St Bartholomew's Hospital
Healthcare•London, United Kingdom•
About: St Bartholomew's Hospital is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Cancer. The organization has 11054 authors who have published 13229 publications receiving 501102 citations. The organization is also known as: St. Bartholomew's Hospital & The Royal Hospital of St Bartholomew.
Topics: Population, Cancer, Pregnancy, Diabetes mellitus, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: It is concluded that these short scales may be useful in helping GPs and practice staff to identify elderly patients with significant depressive symptoms.
Abstract: One-hundred and ninety-eight elderly subjects attending their general practitioners (GPs) were asked to complete the 15 item Geriatric Depression Scale (GDS15). Analysable results were obtained from 194 (98%). Of these, 67 (34%) scored above the GDS15 cut-off (4/5) for significant depressive symptomatology. 87.6% found the questionnaire to be acceptable and only 3.6% found it very difficult or very stressful. The GDS15 had a high level of internal consistency (Cronbach's alpha = 0.80). All the individual items of the GDS15 associated significantly (P < 0.01) with total score and 'caseness'. A single question "do you feel that your life is empty?" identified 84% of 'cases'. In an attempt to devise short scales to screen elderly primary care patients for depression, the data were subjected to logistic regression analysis. Ten (GDS10), four (GDS4) and on (GDS1) item versions were generated. Agreement between these short scales and the GDS15 in the original sample was 95, 91 and 79% respectively. Cronbach's alpha was 0.72 for the GDS10 and 0.55 for the GDS4. The short scales were then validated in an independent sample of 120 patients in whom both GDS data and the results of a detailed psychiatric interview (the Geriatric Mental Status Schedule, GMS) were available. The sensitivity and specificity of the GDS10 against GMS caseness were 87 and 77% (cut-off 3/4); those of the GDS4 were 89 and 65% (cut-off 0/1) and 61 and 81% (cut-off 1/2). Sensitivity and specificity for the GDS1 were 59 and 75%. It is concluded that these short scales may be useful in helping GPs and practice staff to identify elderly patients with significant depressive symptoms.
574 citations
Rolf C. Hagen Group1, University of Tübingen2, University of Hamburg3, Lund University4, Karolinska Institutet5, University of Copenhagen6, Radboud University Nijmegen7, Erasmus University Rotterdam8, Charité9, Institut Gustave Roussy10, University of Duisburg-Essen11, University of Cologne12, The Royal Marsden NHS Foundation Trust13, Norwegian University of Science and Technology14, University of British Columbia15, Hannover Medical School16, University of Amsterdam17, Hochschule Hannover18, Southampton General Hospital19, Oregon Health & Science University20, St Bartholomew's Hospital21, Maastricht University22, University of Mainz23, Martin Luther University of Halle-Wittenberg24, Aarhus University25
TL;DR: F refinements in the treatment of early- and advanced-stage testicular cancer have emerged from clinical trials, and expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer.
569 citations
TL;DR: It is attractive to suggest that the anti-inflammatory actions of NSAIDs are due to inhibition of COX-2, whereas the unwanted side-effects, such as irritation of the stomach lining, are dueto inhibition ofCOX-1.
568 citations
TL;DR: In general, screening for Down's syndrome using both maternal age and serum AFP is more efficient than either alone.
556 citations
TL;DR: It is shown that in ∼80% of primary human CD34+ acute myeloid leukemia (AML), two expanded populations with hemopoietic progenitor immunophenotype coexist in most patients, suggesting that in most cases primaryCD34+ AML is a progenitors disease where LSCs acquire abnormal self-renewal potential.
555 citations
Authors
Showing all 11065 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Philippe Froguel | 166 | 820 | 118816 |
| Geoffrey Burnstock | 141 | 1488 | 99525 |
| Michael A. Kamm | 124 | 637 | 53606 |
| David Scott | 124 | 1561 | 82554 |
| Csaba Szabó | 123 | 958 | 61791 |
| Roger Williams | 122 | 1455 | 72416 |
| Derek M. Yellon | 122 | 638 | 54319 |
| Walter F. Bodmer | 121 | 579 | 68679 |
| John E. Deanfield | 120 | 497 | 61067 |
| Paul Bebbington | 119 | 583 | 46341 |
| William C. Sessa | 117 | 383 | 52208 |
| Timothy G. Dinan | 116 | 689 | 60561 |
| Bruce A.J. Ponder | 116 | 403 | 54796 |
| Alexandra J. Lansky | 114 | 632 | 54445 |
| Glyn Lewis | 113 | 734 | 49316 |