St Bartholomew's Hospital

About: St Bartholomew's Hospital is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Cancer. The organization has 11054 authors who have published 13229 publications receiving 501102 citations. The organization is also known as: St. Bartholomew's Hospital & The Royal Hospital of St Bartholomew.

First trimester concentrations of pregnancy associated plasma protein A and placental protein 14 in Down's syndrome.

Abstract: study more than a third of the abused women had been admitted five times or more The greater differences in admissions in the ages over 30 might be related to ongoing domestic violence Several studies indicate that the risk ofbeing the victim of wife beating is most pronounced in the fourth decade of life' 24 The abused woman, in her exposed and desolate situation, does not always seek medical care for specific somatic diseases3 The "battered wife syndrome" consists of somatic, psychosomatic, and psychiatric symptoms, and psychosocial support is an important reason for seeking hospital care5 Any physician should consider the possibility of ongoing domestic violence when confronted with a female patient lacking other obvious reasons for frequent hospital admissions

Diabetes and arterial hypertension.

Abstract: The epidemiology, pathogenesis, significance and management of hypertension in diabetic subjects are discussed. In Type 1 diabetes the presence of diastolic hypertension is closely related to the presence of diabetic nephropathy, from the stage of persistent proteinuria onwards. There may also be some elevation of systolic pressure. The apparent increased prevalence of hypertension in Type 2 diabetes is largely explicable, directly or indirectly, by obesity but there may be an excess of systolic hypertension among elderly patients. Hypertension in the diabetic population is associated with an increased incidence of both microvascular and macrovascular complications, but whether the high blood pressure is causal is not clear. The possible roles of sodium and insulin, the renin-angiotensin system, catecholamines and physical factors are explored. All current antihypertensive agents have additional limitations and disadvantages when used in diabetic patients: diuretics and beta-blockers are probably the initial drugs of choice. Only in the case of diabetic nephropathy is there yet reasonable evidence of antihypertensive treatment reducing the rate of progression of the disease.

Coupling of enzymes to cellulose using chloro-s-triazines.

Abstract: MANY methods are now available for coupling enzymes and other biologically active compounds to solid supports1–4. Most involve the preliminary preparation of a special support or of a special derivative of a general support such as cellulose; for example, the carboxymethyl or p-amino-benzyl ether derivative. We have therefore sought coupling reagents which allow a more direct approach and have developed the use of cyanuric chloride and dichloro-s-triazines. The latter can be prepared as stable compounds with solubilizing groups such as carboxy–methoxy or carboxy–methylamino, which make them very convenient reagents.