Institution
St Bartholomew's Hospital
Healthcare•London, United Kingdom•
About: St Bartholomew's Hospital is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Cancer. The organization has 11054 authors who have published 13229 publications receiving 501102 citations. The organization is also known as: St. Bartholomew's Hospital & The Royal Hospital of St Bartholomew.
Topics: Population, Cancer, Transplantation, Diabetes mellitus, Pregnancy
Papers published on a yearly basis
Papers
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TL;DR: The possibility that serum unconjugated oestriol measurement may be added to maternal age and alpha‐fetoprotein measurement in the antenatal screening for Down's syndrome is raised.
301 citations
300 citations
TL;DR: In the dosages and schedules investigated, buserlin was ineffective in conserving fertility.
Abstract: The hypothesis that the "down-regulated" gonad is less vulnerable to the effects of cytotoxic chemotherapy for advanced Hodgkin's disease has been investigated. Thirty men and eighteen women were randomly allocated to receive an agonist analogue of gonadotrophin-releasing hormone prior to, and for the duration of, cytotoxic chemotherapy. Buserelin (d-Ser-[TBU]6 LHRH ethylamide) was prescribed in two different dosage schedules to twenty men, and in a single dosage schedule to eight women. A standard gonadotrophin-releasing hormone test (GnRH 100 micrograms) was performed 1 week prior to and on day 1 of each cycle of chemotherapy. In all patients peak luteinizing hormone responses to GnRH were suppressed throughout treatment. The higher of the two dosage schedules used in the men caused more effective suppression of luteinizing hormone, and both regimens led to an initial suppression of peak follicle-stimulating hormone responses to GnRH, which was not maintained. At follow-up assessment up to 3 years from the completion of treatment, all men treated with buserelin were profoundly oligospermic and four of the eight women were amenorrhoeic. All ten male controls were profoundly oligospermic, and six of nine female controls were amenorrhoeic. In the dosages and schedules investigated, buserelin was ineffective in conserving fertility.
299 citations
TL;DR: The inhibitory effects of the peptides used in this study produced effects on dentine resorption which were generally weaker and variable, although osteoclast cell adhesion was consistently inhibited in an Arg-Gly-Asp (RGD)-dependent manner, demonstrating that osteOClast function can be disrupted by low concentrations of the anti-vitronectin receptor antibody, 23C6.
298 citations
University College London1, Imperial College London2, University of Oxford3, Clinical Trial Service Unit4, St Bartholomew's Hospital5, Wellcome Trust Centre for Human Genetics6, University of Glasgow7, Universidade Federal de Pelotas8, University of South Australia9, UCL Institute of Child Health10, European Bioinformatics Institute11, Charité12, University of Lübeck13, Max Planck Society14, Innsbruck Medical University15, Bradford Royal Infirmary16, University of Bristol17, St George's, University of London18, University of Edinburgh19, University of Lausanne20, University of Nicosia21, Cyprus University of Technology22, Utrecht University23, University of Turin24, Cancer Epidemiology Unit25, University of Cambridge26, Russian Academy27, Jagiellonian University28, Lithuanian University of Health Sciences29, University of Copenhagen30, Marshfield Clinic31, Children's Hospital of Philadelphia32, Group Health Research Institute33, Mayo Clinic34, Vanderbilt University35, George Washington University36, University of Newcastle37, Population Health Research Institute38, University Medical Center Groningen39, Leiden University Medical Center40, Uppsala University41, Stanford University42, Science for Life Laboratory43, Erasmus University Medical Center44, Greifswald University Hospital45, University of Regensburg46, University of London47, Robertson Centre for Biostatistics48, university of lille49, French Institute of Health and Medical Research50, University of Nantes51, University of Essex52, Brigham and Women's Hospital53, Fred Hutchinson Cancer Research Center54, University of Colorado Denver55, Geisinger Health System56, Pennsylvania State University57, University of Pennsylvania58
TL;DR: PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, bodyweight, and waist-to-hip ratio, and an increased risk of type 2 diabetes.
296 citations
Authors
Showing all 11065 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Philippe Froguel | 166 | 820 | 118816 |
| Geoffrey Burnstock | 141 | 1488 | 99525 |
| Michael A. Kamm | 124 | 637 | 53606 |
| David Scott | 124 | 1561 | 82554 |
| Csaba Szabó | 123 | 958 | 61791 |
| Roger Williams | 122 | 1455 | 72416 |
| Derek M. Yellon | 122 | 638 | 54319 |
| Walter F. Bodmer | 121 | 579 | 68679 |
| John E. Deanfield | 120 | 497 | 61067 |
| Paul Bebbington | 119 | 583 | 46341 |
| William C. Sessa | 117 | 383 | 52208 |
| Timothy G. Dinan | 116 | 689 | 60561 |
| Bruce A.J. Ponder | 116 | 403 | 54796 |
| Alexandra J. Lansky | 114 | 632 | 54445 |
| Glyn Lewis | 113 | 734 | 49316 |