scispace - formally typeset
Search or ask a question
Institution

St Thomas' Hospital

HealthcareLondon, United Kingdom
About: St Thomas' Hospital is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Pregnancy. The organization has 12105 authors who have published 15596 publications receiving 624309 citations. The organization is also known as: St Thomas's Hospital & St. Thomas's.


Papers
More filters
Journal ArticleDOI
TL;DR: In East Anglia, the use of gas cooking is significantly associated with subjective and objective markers of respiratory morbidity in women but not in men, and these associations were not observed in men.

206 citations

Journal ArticleDOI
TL;DR: The clinical data on 142 pregnancies in 87 patients complicated by pemphigoid gestationis is summarized to provide a comprehensive clinical overview of this disease.
Abstract: Pemphigoid gestationis is a rare vesiculo-bullous disorder of pregnancy. In this review we summarize the clinical data on 142 pregnancies in 87 patients complicated by pemphigoid gestationis. Our aim is to provide a comprehensive clinical overview of this disease.

205 citations

Journal ArticleDOI
TL;DR: HNF-4α mutations are common when no HNF-1α mutation is found in strictly defined MODY families and are associated with reduced apolipoprotein A2 levels.
Abstract: Aims/hypothesis Heterozygous mutations in the gene of the transcription factor hepatocyte nuclear factor 4α (HNF-4α) are considered a rare cause of MODY with only 14 mutations reported to date. The description of the phenotype is limited to single families. We investigated the genetics and phenotype of HNF-4α mutations in a large European Caucasian collection.

205 citations

Journal ArticleDOI
TL;DR: There is evidence that the use of screening instruments in combination with asking parents about their concerns improves the efficiency of an instrument, but the number and type of concerns that parents have about their child's behaviour and development determine whether using a screening instrument within the clinic setting is effective.
Abstract: Screening and surveillance are different but related activities involving the detection of impairments with a view to prevention or amelioration of consequent disability and handicap. Screening is the prospective identification of unrecognised disorder by the application of specific tests or examinations. Surveillance refers to the ongoing and systematic collection of data relevant to the identification of a disorder over time by an integrated health system. The review by Hall1 in Health for all children concluded that most screening tests that set out to identify neurodevelopmental disorders do not meet the stringent criteria outlined by Cochrane and Holland2 and Wilson and Jungner.3 In some conditions, for example language disorders, this is because there is uncertainty about “caseness” and tests tend to have low sensitivity and specificity.4 5 This is particularly the case for screening tests that attempt to identify a specific condition rather than general developmental delay, and for the identification of relatively rare disorders. In the latter case, even when the sensitivity and specificity of a screen remain constant, the positive predictive value (the proportion of children with a positive screen result and who have the disorder) is lower the rarer a disorder is within the population.6 The concept of developmental surveillance is a parent–professional partnership that takes a broader look at developmental and behavioural skills and progress over time. It combines the observations of parents with the developmental knowledge of the professional and the deployment of specific tests. There is evidence that the use of screening instruments in combination with asking parents about their concerns improves the efficiency of an instrument.7 8 However, the number and type of concerns that parents have about their child's behaviour and development determine whether using a screening instrument within the clinic setting is effective. For example, Glascoe, …

205 citations

Journal ArticleDOI
TL;DR: The results do not support Clock 3111C as a marker for diurnal preference, τ, or delayed sleep phase syndrome in humans.
Abstract: Mutations in clock genes are associated with abnormal circadian parameters, including sleep An association has been reported previously between a polymorphism (3111C), situated in the 3�-untranslated region (3�-UTR) of the circadian gene Clock and evening preference In the present study, this polymorphism was assessed in: (1) 105 control subjects with defined diurnal preference, (2) 26 blind subjects with free-running circadian rhythms and characterized with regard to circadian period (I�) and (3) 16 delayed sleep phase syndrome patients The control group was chosen from a larger population (n = 484) by Horne-A�stberg questionnaire analysis, from which three subgroups were selected (evening, intermediate and morning preference) Data from sleep diaries completed by 90% of these subjects showed a strong correlation between preferred and estimated timings of sleep and wake The mean timings of activities for the evening group were at least 2 h later than the morning group Genetic analysis showed that, in contrast with the previously published finding, there was no association between 3111C and eveningness Neither was there an association between 3111C and I�, nor a significant difference in 3111C frequency between the normal and delayed sleep phase syndrome groups To assess the effect of this polymorphism on messenger RNA (mRNA) translatability, luciferase reporter gene constructs containing the two Clock polymorphic variants in their 3�-UTR were transfected into COS-1 cells and luciferase activity measured No significant difference was observed between the two variants These results do not support Clock 3111C as a marker for diurnal preference, I�, or delayed sleep phase syndrome in humans

205 citations


Authors

Showing all 12132 results

NameH-indexPapersCitations
David J. Hunter2131836207050
Rory Collins162489193407
Steven Williams144137586712
Geoffrey Burnstock141148899525
Nick C. Fox13974893036
Christopher D.M. Fletcher13867482484
David A. Jackson136109568352
Paul Harrison133140080539
Roberto Ferrari1331654103824
David Taylor131246993220
Keith Hawton12565755138
Nicole Soranzo12431674494
Roger Williams122145572416
John C. Chambers12264571028
Derek M. Yellon12263854319
Network Information
Related Institutions (5)
Hammersmith Hospital
14.3K papers, 769.1K citations

93% related

John Radcliffe Hospital
23.6K papers, 1.4M citations

93% related

Leiden University Medical Center
38K papers, 1.6M citations

92% related

Radboud University Nijmegen Medical Centre
12.6K papers, 659.2K citations

92% related

University Medical Center Groningen
30.3K papers, 967K citations

91% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20237
202235
2021654
2020595
2019485
2018462