Institution
St Thomas' Hospital
Healthcare•London, United Kingdom•
About: St Thomas' Hospital is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Pregnancy. The organization has 12105 authors who have published 15596 publications receiving 624309 citations. The organization is also known as: St Thomas's Hospital & St. Thomas's.
Papers published on a yearly basis
Papers
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TL;DR: Diabetic maculopathy is characterized by the accumulation of extracellular fluid in Henle's layer and the inner nuclear layer of the retina, and the underlying biochemical stimulus to the production of vascular endothelial growth factor is chronic hyperglycaemia.
Abstract: Diabetic maculopathy is characterized by the accumulation of extracellular fluid in Henle's layer and the inner nuclear layer of the retina. The localization of the edema is likely to be due, in part, to the relative barrier properties of the inner and outer plexiform layers. The origin of the extracellular fluid is from the intravascular compartment. Although changes to retinal blood flow may partly explain the extravasation of fluid, the most important mechanism is breakdown of the blood retinal barriers. Both the inner blood retinal barrier formed by the retinal capillary endothelial cell tight junctions and the outer barrier formed by the retinal pigment epithelial cell tight junctions can be affected. The mechanism of breakdown of the blood retinal barriers is likely to be changes to the tight junction proteins including occludin and ZO-1. The biochemical messenger inducing these changes may be vascular endothelial growth factor. The origin of this or other cofactors may be the retinal glial cells. The underlying biochemical stimulus to the production of vascular endothelial growth factor is chronic hyperglycaemia, but it is uncertain by what pathway this is effected.
350 citations
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University of Zurich1, Leiden University Medical Center2, Duke University3, Stanford University4, University of Florence5, St Thomas' Hospital6, Tel Aviv University7, University of Graz8, University of Milano-Bicocca9, Memorial Sloan Kettering Cancer Center10, Peter MacCallum Cancer Centre11, Northwestern University12, University of Barcelona13, University of São Paulo14, University of Texas MD Anderson Cancer Center15, University of Helsinki16, University of Vienna17, University of Wisconsin-Madison18
TL;DR: Recommendations represent the state-of-the-art management of CD30(+) LPDs and include definitions for clinical endpoints as well as response criteria for future clinical trials in CD30 (+) L PDs.
347 citations
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Tufts Medical Center1, Charité2, American Medical Association3, Erasmus University Rotterdam4, Harvard University5, University of British Columbia6, University of Washington7, University of Pittsburgh8, Veterans Health Administration9, Yale University10, Children's Hospital at Westmead11, Great Ormond Street Hospital for Children NHS Foundation Trust12, American Society of Nephrology13, University of Maryland, Baltimore14, Royal Free London NHS Foundation Trust15, University of Pennsylvania16, University Medical Center Groningen17, Mayo Clinic18, University of Calgary19, University of Michigan20, Keele University21, University of Oklahoma Health Sciences Center22, St Thomas' Hospital23, University of Paris24, French Institute of Health and Medical Research25, Heidelberg University26, National Kidney Foundation27, University College London28, Cliniques Universitaires Saint-Luc29, Baylor College of Medicine30
TL;DR: Recommendations to use "kidney" rather than "renal" or "nephro-" when referring to kidney disease and kidney function and to use the KDIGO definition and classification of chronic kidney disease rather than alternative descriptions to define and classify severity of CKD.
347 citations
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TL;DR: Nanopore sequencing coupled with a metagenomics framework that effectively removes human DNA from samples enables rapid bacterial LRI diagnosis and might contribute to a reduction in broad-spectrum antibiotic use.
Abstract: The gold standard for clinical diagnosis of bacterial lower respiratory infections (LRIs) is culture, which has poor sensitivity and is too slow to guide early, targeted antimicrobial therapy. Metagenomic sequencing could identify LRI pathogens much faster than culture, but methods are needed to remove the large amount of human DNA present in these samples for this approach to be feasible. We developed a metagenomics method for bacterial LRI diagnosis that features efficient saponin-based host DNA depletion and nanopore sequencing. Our pilot method was tested on 40 samples, then optimized and tested on a further 41 samples. Our optimized method (6 h from sample to result) was 96.6% sensitive and 41.7% specific for pathogen detection compared with culture and we could accurately detect antibiotic resistance genes. After confirmatory quantitative PCR and pathobiont-specific gene analyses, specificity and sensitivity increased to 100%. Nanopore metagenomics can rapidly and accurately characterize bacterial LRIs and might contribute to a reduction in broad-spectrum antibiotic use.
346 citations
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TL;DR: In the first year of life exposure to cigarette smoke generated when parents smoked doubled the risk for the infant of an attack of pneumonia or bronchitis.
346 citations
Authors
Showing all 12132 results
Name | H-index | Papers | Citations |
---|---|---|---|
David J. Hunter | 213 | 1836 | 207050 |
Rory Collins | 162 | 489 | 193407 |
Steven Williams | 144 | 1375 | 86712 |
Geoffrey Burnstock | 141 | 1488 | 99525 |
Nick C. Fox | 139 | 748 | 93036 |
Christopher D.M. Fletcher | 138 | 674 | 82484 |
David A. Jackson | 136 | 1095 | 68352 |
Paul Harrison | 133 | 1400 | 80539 |
Roberto Ferrari | 133 | 1654 | 103824 |
David Taylor | 131 | 2469 | 93220 |
Keith Hawton | 125 | 657 | 55138 |
Nicole Soranzo | 124 | 316 | 74494 |
Roger Williams | 122 | 1455 | 72416 |
John C. Chambers | 122 | 645 | 71028 |
Derek M. Yellon | 122 | 638 | 54319 |