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Showing papers by "State University of New York System published in 2009"


Journal ArticleDOI
11 Dec 2009-Science
TL;DR: A unifying model framework describing the atmospheric evolution of OA that is constrained by high–time-resolution measurements of its composition, volatility, and oxidation state is presented, which can serve as a basis for improving parameterizations in regional and global models.
Abstract: Organic aerosol (OA) particles affect climate forcing and human health, but their sources and evolution remain poorly characterized. We present a unifying model framework describing the atmospheric evolution of OA that is constrained by high-time-resolution measurements of its composition, volatility, and oxidation state. OA and OA precursor gases evolve by becoming increasingly oxidized, less volatile, and more hygroscopic, leading to the formation of oxygenated organic aerosol (OOA), with concentrations comparable to those of sulfate aerosol throughout the Northern Hemisphere. Our model framework captures the dynamic aging behavior observed in both the atmosphere and laboratory: It can serve as a basis for improving parameterizations in regional and global models.

3,104 citations


Journal ArticleDOI
TL;DR: In this paper, Tuck calls on communities, researchers, and educators to reconsider the long-term impact of "damage-centered" research, which intends to document peoples' pain and brokenness to hold those in power accountable for their oppression.
Abstract: In this open letter, Eve Tuck calls on communities, researchers, and educators to reconsider the long-term impact of "damage-centered" research—research that intends to document peoples' pain and brokenness to hold those in power accountable for their oppression. This kind of research operates with a flawed theory of change: it is often used to leverage reparations or resources for marginalized communities yet simultaneously reinforces and reinscribes a one-dimensional notion of these people as depleted, ruined, and hopeless. Tuck urges communities to institute a moratorium on damage-centered research to reformulate the ways research is framed and conducted and to reimagine how findings might be used by, for, and with communities.

1,345 citations


Journal ArticleDOI
TL;DR: In this paper, the main features of the climate and climate variability over South America, on the basis of instrumental observations gathered during the 20th century, are described and a basic physical understanding of the mean annual cycle of the precipitation and atmospheric circulation over the continent and the adjacent oceans.

1,246 citations


Journal ArticleDOI
TL;DR: In this paper, positive matrix factorization (PMF) was used to identify and interpret the organic aerosol (OA) data from an Aerodyne Aerosol Mass Spectrometer (Q-AMS) collected at the Pittsburgh Air Quality Study (PAQS) in September 2002.
Abstract: . The organic aerosol (OA) dataset from an Aerodyne Aerosol Mass Spectrometer (Q-AMS) collected at the Pittsburgh Air Quality Study (PAQS) in September 2002 was analyzed with Positive Matrix Factorization (PMF). Three components – hydrocarbon-like organic aerosol OA (HOA), a highly-oxygenated OA (OOA-1) that correlates well with sulfate, and a less-oxygenated, semi-volatile OA (OOA-2) that correlates well with nitrate and chloride – are identified and interpreted as primary combustion emissions, aged SOA, and semivolatile, less aged SOA, respectively. The complexity of interpreting the PMF solutions of unit mass resolution (UMR) AMS data is illustrated by a detailed analysis of the solutions as a function of number of components and rotational forcing. A public web-based database of AMS spectra has been created to aid this type of analysis. Realistic synthetic data is also used to characterize the behavior of PMF for choosing the best number of factors, and evaluating the rotations of non-unique solutions. The ambient and synthetic data indicate that the variation of the PMF quality of fit parameter (Q, a normalized chi-squared metric) vs. number of factors in the solution is useful to identify the minimum number of factors, but more detailed analysis and interpretation are needed to choose the best number of factors. The maximum value of the rotational matrix is not useful for determining the best number of factors. In synthetic datasets, factors are "split" into two or more components when solving for more factors than were used in the input. Elements of the "splitting" behavior are observed in solutions of real datasets with several factors. Significant structure remains in the residual of the real dataset after physically-meaningful factors have been assigned and an unrealistic number of factors would be required to explain the remaining variance. This residual structure appears to be due to variability in the spectra of the components (especially OOA-2 in this case), which is likely to be a key limit of the retrievability of components from AMS datasets using PMF and similar methods that need to assume constant component mass spectra. Methods for characterizing and dealing with this variability are needed. Interpretation of PMF factors must be done carefully. Synthetic data indicate that PMF internal diagnostics and similarity to available source component spectra together are not sufficient for identifying factors. It is critical to use correlations between factor and external measurement time series and other criteria to support factor interpretations. True components with

1,148 citations


Journal ArticleDOI
TL;DR: In this article, the authors investigated the impact of two cultural antecedents, market orientation and learning orientation, and three organizational practices, all aimed at augmenting the supply chain agility of a firm.

978 citations


Journal ArticleDOI
TL;DR: In this article, the authors provide a more direct test of the gender roles hypothesis by analyzing community epidemiological data collected from respondents surveyed in 15 countries as part of the World Health Organization (WHO) World Mental Health (WMH) Survey Initiative.
Abstract: Epidemiological surveys have consistently documented significantly higher rates of anxiety and mood disorders among women than men1, 2 and significantly higher rates of externalizing and substance use disorders among men than women.3–5 Although a number of biological, psychosocial, and biopsychosocial hypotheses have been proposed to account for these patterns,6–8 evidence that gender differences in depression9, 10 and substance use11–13 have narrowed in a number of countries has led to a special interest in the “gender roles” hypothesis. The latter asserts that gender differences in the prevalence of mental disorders are due to differences in the typical stressors, coping resources, and opportunity structures for expressing psychological distress made available differentially to women and men in different countries at different points in history.14, 15 Consistent with this hypothesis, evidence of decreasing gender differences in depression and substance use has been found largely in countries where the roles of women have improved in terms of opportunities for employment, access to birth control, and other indicators of increasing gender role equality, while trend studies in countries where gender roles have been more static11, 16 or over periods of historical time when gender role changes have been small17 have failed to document a reduction in gender differences in depression or substance use. Most research aimed at investigating the gender roles hypothesis has focused on individual-level variation in roles in a single country at a single point in time.18–20 This approach is limited in three ways. First, selection bias into roles due to pre-existing mental illness (e.g., women with agoraphobia having a higher probability than other women of becoming homemakers rather than seeking employment outside the home) confounds attempts to evaluate the causal effects of gender roles. Second, gender differences are largely confined to differences in lifetime risk, with much less evidence for gender differences in recent prevalence among lifetime cases.21 This means that investigation of the determinants of gender difference should focus on lifetime first onset rather than on the recent prevalence that has been the focus of most studies. Third, as the gender roles hypothesis is a hypothesis about the effects of social context, a rigorous test of the hypothesis requires an analysis of societal-level time-space variation rather than analysis of the individual-level variation that has been the focus of most studies. A small number of cross-national comparative studies have examined spatial variation in gender differences in depression22 and alcohol abuse13 at a point in time or, more rarely, at two points in time.11 Although these studies raised the possibility that gender roles might be associated with variation in the magnitude of gender differences in these outcomes, they were unable to test this hypothesis due to the small number of cross-sectional country-level observations included in the analyses. The current report provides a more direct test of the gender roles hypothesis by analyzing community epidemiological data collected from respondents surveyed in 15 countries as part of the World Health Organization (WHO) World Mental Health (WMH) Survey Initiative.21 Previous cross-national comparisons of gender differences in mental illness focused on cross-sectional differences. We, in comparison, use retrospective reports obtained in the WMH surveys about lifetime occurrence and age-of-onset of mental disorders in different birth cohorts to study time-space variation in lifetime risk. Specifically, we examine both variation across cohorts within a single country (i.e., temporal variation) and variation across countries within a single cohort (i.e., special variation) in lifetime risk of mental disorders as a function of time-space variation in the traditionality of gender roles. Lifetime risk is the focus rather than recent prevalence even though accuracy of reporting is doubtlessly better for recent episodes than lifetime occurrence in order to address the fact that gender differences in lifetime risk are much more robust than gender differences in current prevalence among lifetime cases

972 citations


Journal ArticleDOI
TL;DR: The Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors.
Abstract: The commensal fungus Candida albicans causes oropharyngeal candidiasis (OPC; thrush) in settings of immunodeficiency. Although disseminated, vaginal, and oral candidiasis are all caused by C. albicans species, host defense against C. albicans varies by anatomical location. T helper 1 (Th1) cells have long been implicated in defense against candidiasis, whereas the role of Th17 cells remains controversial. IL-17 mediates inflammatory pathology in a gastric model of mucosal candidiasis, but is host protective in disseminated disease. Here, we directly compared Th1 and Th17 function in a model of OPC. Th17-deficient (IL-23p19(-/-)) and IL-17R-deficient (IL-17RA(-/-)) mice experienced severe OPC, whereas Th1-deficient (IL-12p35(-/-)) mice showed low fungal burdens and no overt disease. Neutrophil recruitment was impaired in IL-23p19(-/-) and IL-17RA(-/-), but not IL-12(-/-), mice, and TCR-alphabeta cells were more important than TCR-gammadelta cells. Surprisingly, mice deficient in the Th17 cytokine IL-22 were only mildly susceptible to OPC, indicating that IL-17 rather than IL-22 is vital in defense against oral candidiasis. Gene profiling of oral mucosal tissue showed strong induction of Th17 signature genes, including CXC chemokines and beta defensin-3. Saliva from Th17-deficient, but not Th1-deficient, mice exhibited reduced candidacidal activity. Thus, the Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors.

931 citations


Journal ArticleDOI
TL;DR: In this article, the role of socially constructed gender stereotypes in entrepreneurship and their influence on men and women's entrepreneurial intentions was examined and found that those who perceived themselves as more similar to males (high on male gender identification) had higher entrepreneurial intentions than those who saw themselves as less similar to females (low male identification).
Abstract: In this study we examine the role of socially constructed gender stereotypes in entrepreneurship and their influence on men and women's entrepreneurial intentions. Data on characteristics of males, females, and entrepreneurs were collected from young adults in three countries. As hypothesized, entrepreneurs were perceived to have predominantly masculine characteristics. Additional results revealed that although both men and women perceive entrepreneurs to have characteristics similar to those of males (masculine gender-role stereotype), only women also perceived entrepreneurs and females as having similar characteristics (feminine gender-role stereotype). Further, though men and women did not differ in their entrepreneurial intentions, those who perceived themselves as more similar to males (high on male gender identification) had higher entrepreneurial intentions than those who saw themselves as less similar to males (low male gender identification). No such difference was found for people who saw themselves as more or less similar to females (female gender identification). The results were consistent across the three countries. Practical implications and directions for future research are discussed.

839 citations


Journal ArticleDOI
TL;DR: A meta-analysis of datasets for multiple psychiatric disorders showed a significant association of the microduplication with schizophrenia, bipolar disorder, and autism, while the reciprocal microdeletion was associated only with autism and developmental disorders.
Abstract: Recurrent microdeletions and microduplications of a 600-kb genomic region of chromosome 16p11.2 have been implicated in childhood-onset developmental disorders1, 2, 3. We report the association of 16p11.2 microduplications with schizophrenia in two large cohorts. The microduplication was detected in 12/1,906 (0.63%) cases and 1/3,971 (0.03%) controls (P = 1.2 10-5, OR = 25.8) from the initial cohort, and in 9/2,645 (0.34%) cases and 1/2,420 (0.04%) controls (P = 0.022, OR = 8.3) of the replication cohort. The 16p11.2 microduplication was associated with a 14.5-fold increased risk of schizophrenia (95% CI (3.3, 62)) in the combined sample. A meta-analysis of datasets for multiple psychiatric disorders showed a significant association of the microduplication with schizophrenia (P = 4.8 10-7), bipolar disorder (P = 0.017) and autism (P = 1.9 10-7). In contrast, the reciprocal microdeletion was associated only with autism and developmental disorders (P = 2.3 10-13). Head circumference was larger in patients with the microdeletion than in patients with the microduplication (P = 0.0007).

689 citations


MonographDOI
19 Jan 2009
TL;DR: In this paper, the concepts of space, time, frequency diversity, and MIMO with a holistic approach to principal topics where significant improvements can be obtained are presented, with an ideal textbook for advanced courses on wireless communications.
Abstract: Presenting the fundamentals of cooperative communications and networking, this book treats the concepts of space, time, frequency diversity and MIMO, with a holistic approach to principal topics where significant improvements can be obtained. Beginning with background and MIMO systems, Part I includes a review of basic principles of wireless communications and space-time diversity and coding. Part II then presents topics on physical layer cooperative communications such as relay channels and protocols, performance bounds, multi-node cooperation, and energy efficiency. Finally, Part III focuses on cooperative networking including cooperative and content-aware multiple access, distributed routing, source-channel coding, and cooperative OFDM. Including end-of-chapter review questions, this text will appeal to graduate students of electrical engineering and is an ideal textbook for advanced courses on wireless communications. It will also be of great interest to practitioners in the wireless communications industry. Presentation slides for each chapter and instructor-only solutions are available at www.cambridge.org/9780521895132.

607 citations


Journal ArticleDOI
TL;DR: In this article, an efficient up-and down-converted photoluminescence from the rare-earth ions (Er 3+ and Yb 3+ or Eu 3+ ) doped into fluoride nanomatrix allows optical imaging modality for the nanoprobes.
Abstract: Here, novel nanoprobes for combined optical and magnetic resonance (MR) bioimaging are reported. Fluoride (NaYF 4 ) nanocrystals (20-30 nm size) co-doped with the rare earth ions Gd 3+ and Er 3+ /Yb 3+ /Eu 3+ are synthesized and dispersed in water. An efficient up- and downconverted photoluminescence from the rare-earth ions (Er 3+ and Yb 3+ or Eu 3+ ) doped into fluoride nanomatrix allows optical imaging modality for the nanoprobes. Upconversion nanophosphors (UCNPs) show nearly quadratic dependence of the photoluminescence intensity on the excitation light power, confirming a two-photon induced process and allowing two-photon imaging with UCNPs with low power continuous wave laser diodes due to the sequential nature of the two-photon process. Furthermore, both UCNPs and downconversion nanophosphors (DCNPs) are modified with biorecognition biomolecules such as anti-claudin-4 and anti-mesothelin, and show in vitro targeted delivery to cancer cells using confocal microscopy. The possibility of using nanoprobes for optical imaging in vivo is also demonstrated. It is also shown that Gd 3+ co-doped within the nanophosphors imparts strong T1 (Spin-lattice relaxation time) and T2 (spin-spin relaxation time) for high contrast MR imaging. Thus, nanoprobes based on fluoride nanophosphors doped with rare earth ions are shown to provide the dual modality of optical and magnetic resonance imaging.

Journal ArticleDOI
TL;DR: The reflective and interrogative processes required for developing effective qualitative research questions can give shape and direction to a study in ways that are often underestimated as discussed by the authors, and how the processes of generating and refining questions are critical to the shaping of a qualitative study.
Abstract: The reflective and interrogative processes required for developing effective qualitative research questions can give shape and direction to a study in ways that are often underestimated. Good research questions do not necessarily produce good research, but poorly conceived or constructed questions will likely create problems that affect all subsequent stages of a study. In qualitative studies, the ongoing process of questioning is an integral part of understanding the unfolding lives and perspectives of others. This article addresses both the development of initial research questions and how the processes of generating and refining questions are critical to the shaping of a qualitative study.

Journal ArticleDOI
TL;DR: The study validates an instrument designed to measure teaching, social, and cognitive presence indicative of a community of learners within the community of inquiry (CoI) framework and determined that 70% of the variance in the online students' levels of cognitive presence can be modeled based on their reports of their instructors' skills in fostering teaching presence.
Abstract: In this paper, several recent theoretical conceptions of technology-mediated education are examined and a study of 2159 online learners is presented. The study validates an instrument designed to measure teaching, social, and cognitive presence indicative of a community of learners within the community of inquiry (CoI) framework [Garrison, D. R., Anderson, T., & Archer, W. (2000). Critical inquiry in a text-based environment: Computer conferencing in higher education. The Internet and Higher Education, 2, 1-19; Garrison, D. R., Anderson, T., & Archer, W. (2001). Critical thinking, cognitive presence, and computer conferencing in distance education. American Journal of Distance Education, 15(1), 7-23]. Results indicate that the survey items cohere into interpretable factors that represent the intended constructs. Further it was determined through structural equation modeling that 70% of the variance in the online students' levels of cognitive presence, a multivariate measure of learning, can be modeled based on their reports of their instructors' skills in fostering teaching presence and their own abilities to establish a sense of social presence. Additional analysis identifies more details of the relationship between learner understandings of teaching and social presence and its impact on their cognitive presence. Implications for online teaching, policy, and faculty development are discussed.

Journal ArticleDOI
TL;DR: There is strong and consistent evidence that behavioral treatments are effective for treating ADHD.

Journal ArticleDOI
TL;DR: A multisegment reverse transcription-PCR approach that simultaneously amplifies eight genomic RNA segments, irrespective of virus subtype is developed and used to rescue a contemporary H3N2 virus and a swine origin H1N1 virus directly from human swab specimens.
Abstract: Pandemic influenza A viruses that emerge from animal reservoirs are inevitable. Therefore, rapid genomic analysis and creation of vaccines are vital. We developed a multisegment reverse transcription-PCR (M-RTPCR) approach that simultaneously amplifies eight genomic RNA segments, irrespective of virus subtype. M-RTPCR amplicons can be used for high-throughput sequencing and/or cloned into modified reverse-genetics plasmids via regions of sequence identity. We used these procedures to rescue a contemporary H3N2 virus and a swine origin H1N1 virus directly from human swab specimens. Together, M-RTPCR and the modified reverse-genetics plasmids that we designed streamline the creation of vaccine seed stocks (9 to 12 days).

Posted Content
TL;DR: This article concludes with a strong recommendation for the mandatory electronic recording of interrogations and considers other possibilities for the reform of interrogation practices and the protection of vulnerable suspect populations.
Abstract: Recent DNA exonerations have shed light on the problem that people sometimes confess to crimes they did not commit. Drawing on police practices, laws concerning the admissibility of confession evidence, core principles of psychology, and forensic studies involving multiple methodologies, this White Paper summarizes what is known about police-induced confessions. In this review, we identify suspect characteristics (e.g., adolescence; intellectual disability; mental illness; and certain personality traits), interrogation tactics (e.g., excessive interrogation time; presentations of false evidence; and minimization), and the phenomenology of innocence (e.g., the tendency to waive Miranda rights) that influence confessions as well as their effects on judges and juries. This article concludes with a strong recommendation for the mandatory electronic recording of interrogations and considers other possibilities for the reform of interrogation practices and the protection of vulnerable suspect populations.

Journal ArticleDOI
TL;DR: These studies suggest that astrocytes in the RTT brain carrying MeCP2 mutations have a non–cell autonomous effect on neuronal properties, probably as a result of aberrant secretion of soluble factor(s).
Abstract: The neurodevelopmental disorder Rett syndrome (RTT) is caused by sporadic mutations in the transcriptional factor methyl-CpG-binding protein 2 (MeCP2). Although it is thought that the primary cause of RTT is cell autonomous, resulting from a lack of functional MeCP2 in neurons, whether non-cell autonomous factors contribute to the disease is unknown. We found that the loss of MeCP2 occurs not only in neurons but also in glial cells of RTT brains. Using an in vitro co-culture system, we found that mutant astrocytes from a RTT mouse model, and their conditioned medium, failed to support normal dendritic morphology of either wild-type or mutant hippocampal neurons. Our studies suggest that astrocytes in the RTT brain carrying MeCP2 mutations have a non-cell autonomous effect on neuronal properties, probably as a result of aberrant secretion of soluble factor(s).

Journal ArticleDOI
TL;DR: In this article, a design experiment was conducted over three successive school years, with the teacher's goal of having his Grade 4 students assume increasing levels of collective responsibility for advancing their knowledge of optics.
Abstract: This article reports a design experiment conducted over three successive school years, with the teacher's goal of having his Grade 4 students assume increasing levels of collective responsibility for advancing their knowledge of optics. Classroom practices conducive to sustained knowledge building were co-constructed by the teacher and students, with Knowledge Forum software supporting the production and refinement of the community's knowledge. Social network analysis and qualitative analyses were used to assess online participatory patterns and knowledge advances, focusing on indicators of collective cognitive responsibility. Data indicate increasingly effective procedures, mirrored in students' knowledge advances, corresponding to the following organizations: (a) Year 1—fixed small-groups; (b) Year 2—interacting small-groups with substantial cross-group knowledge sharing; and (c) Year 3—opportunistic collaboration, with small teams forming and disbanding under the volition of community members, based on...

Journal ArticleDOI
TL;DR: In this article, the empirical determinants of China's outward direct investment (ODI) are investigated and it is found that China's investments in developed and developing countries are driven by different sets of factors.
Abstract: We investigate the empirical determinants of China’s outward direct investment (ODI). It is found that China’s investments in developed and developing countries are driven by different sets of factors. Subject to the differences between developed and developing countries, there is evidence that a) both market seeking and resources seeking motives drive China’s ODI, b) the Chinese exports to developing countries induce China’s ODI, c) China’s international reserves promote its ODI, and d) the Chinese capital tends to agglomerate among developed economies but diversify among developing economies. Similar results are obtained using alternative ODI data. We do not find substantial evidence that China invests in African and oil-producing countries mainly for their natural resources.

Journal ArticleDOI
TL;DR: This tutorial review will give an overview of the most versatile reactions of donor/acceptor carbenoids, an exciting class of intermediates capable of highly selective reactions, including cyclopropanation, [4 + 3] cycloaddition, and C-H functionalization methodologies.
Abstract: The metal catalyzed reactions of diazo compounds have been broadly used in organic synthesis. The resulting metal–carbenoid intermediates are capable of undergoing a range of unconventional reactions, and due to their high energy, they are ideal for initiating cascade sequences leading to the rapid generation of structural complexity. This tutorial review will give an overview of the most versatile reactions of donor/acceptor carbenoids, an exciting class of intermediates capable of highly selective reactions. This will include cyclopropanation, [4 + 3] cycloaddition, and C–H functionalization methodologies. The application of this chemistry to the synthesis of a range of natural products will be described.

Journal ArticleDOI
TL;DR: Sharon S. Dawes as discussed by the authors is a senior fellow at the Center for Technology in Government, professor emerita of public administration and policy, and affi leate faculty member in informatics at the University at Albany, State University of New York.
Abstract: Sharon S. Dawes is a senior fellow at the Center for Technology in Government, professor emerita of public administration and policy, and affi liate faculty member in informatics at the University at Albany, State University of New York. As founding director from 1993 to 2007, she led the Center for Technology in Government to international prominence in applied digital government research. A fellow of the National Academy of Public Administration, she was elected the fi rst president of the Digital Government Society of North America in 2006. She serves on advisory committees for the U.S. National Science Foundation, the National Archives and Records Administration, and the United Nations University. Her main re- search interests are government information strategy and management, international research collaboration, and cross-boundary information sharing and integration.

Journal ArticleDOI
TL;DR: This meta-analysis aggregates data from 37 studies from pregnancy to after the birth of the first child and 4 studies that track childless newlywed couples over time and indicates that those who do and do not become parents experience a decrease in relationship satisfaction similar to that of parents across a comparable span of time.
Abstract: The U.S. government has recently spent several hundred million dollars to promote healthy relationships in new parents. The influx of money implies that relationships of new parents are at elevated risk for declining satisfaction and dissolution. This meta-analysis aggregates data from 37 studies that track couples from pregnancy to after the birth of the first child and 4 studies that track childless newlywed couples over time and compare couples who do and do not become parents. Results indicate significant, small declines in relationship satisfaction for both men and women from pregnancy to 11-months post-birth; five studies that followed couples for 12–14 months found moderate-sized declines. Seven variables moderated the decrease in relationship satisfaction from pregnancy to early parenthood. However, the decrease in satisfaction may not indicate anything unique about the transition to parenthood; the four studies following newlyweds indicated that those who do not become parents experience a similar decrease in relationship satisfaction as parents do across a comparable span of time. Implications for prevention and future directions are discussed.

Journal ArticleDOI
TL;DR: In this paper, an advanced particle microphysics model with a number of computationally efficient schemes has been incorporated into a global chemistry transport model (GEOS-Chem) to simulate particle number size distributions and cloud condensation nuclei (CCN) concentrations in the atmosphere.
Abstract: . An advanced particle microphysics model with a number of computationally efficient schemes has been incorporated into a global chemistry transport model (GEOS-Chem) to simulate particle number size distributions and cloud condensation nuclei (CCN) concentrations in the atmosphere. Size-resolved microphysics for secondary particles (i.e., those formed from gaseous species) and sea salt has been treated in the present study. The growth of nucleated particles through the condensation of sulfuric acid vapor and equilibrium uptake of nitrate, ammonium, and secondary organic aerosol is explicitly simulated, along with the scavenging of secondary particles by primary particles (dust, black carbon, organic carbon, and sea salt). We calculate secondary particle formation rate based on ion-mediated nucleation (IMN) mechanism and constrain the parameterizations of primary particle emissions with various observations. Our simulations indicate that secondary particles formed via IMN appear to be able to account for the particle number concentrations observed in many parts of the troposphere. A comparison of the simulated annual mean concentrations of condensation nuclei larger than 10 nm (CN10) with those measured values show very good agreement (within a factor of two) in near all 22 sites around the globe that have at least one full year of CN10 measurements. Secondary particles appear to dominate the number abundance in most parts of the troposphere. Calculated CCN concentration at supersaturation of 0.4% (CCN0.4) and the fraction of CCN0.4 that is secondary (fsecCCN) have large spatial variations. Over the middle latitude in the Northern Hemisphere, zonally averaged CCN0.4 decreases from ~400–700 cm−3 in the boundary layer (BL) to below 100 cm−3 above altitude of ~4 km, the corresponding fsecCCN values change from 50–60% to above ~70%. In the Southern Hemisphere, the zonally averaged CCN0.4 is below 200 cm−3 and fsecCCN is generally above 60% except in the BL over the Southern Ocean.

Journal ArticleDOI
TL;DR: In this paper, two regional joint sets (J1 and J2 sets) are observed in outcrop, core, and borehole images of the marine Middle and Upper Devonian section of the Appalachian Basin.
Abstract: The marine Middle and Upper Devonian section of the Appalachian Basin includes several black shale units that carry two regional joint sets (J1 and J2 sets) as observed in outcrop, core, and borehole images. These joints formed close to or at peak burial depth as natural hydraulic fractures induced by abnormal fluid pressures generated during thermal maturation of organic matter. When present together, earlier J1 joints are crosscut by later J2 joints. In outcrops of black shale on the foreland (northwest) side of the Appalachian Basin, the east-northeast–trending J1 set is more closely spaced than the northwest-striking J2 set. However, J2 joints are far more pervasive throughout the exposed Devonian marine clastic section on both sides of the basin. By geological coincidence, the J1 set is nearly parallel the maximum compressive normal stress of the contemporary tectonic stress field (SHmax). Because the contemporary tectonic stress field favors the propagation of hydraulic fracture completions to the east-northeast, fracture stimulation from vertical wells intersects and drains J2 joints. Horizontal drilling and subsequent stimulation benefit from both joint sets. By drilling in the north-northwest–south-southeast directions, horizontal wells cross and drain J1 joints, whenever present. Then, staged hydraulic fracture stimulations, if necessary, run east-northeast (i.e., parallel to the J1 set) under the influence of the contemporary tectonic stress field thereby crosscutting and draining J2 joints.

Journal ArticleDOI
TL;DR: Moraxella catarrhalis is an exclusively human pathogen and is a common cause of otitis media in infants and children, causing 15%-20% of acute otitisMedia episodes, and in adults with chronic obstructive pulmonary disease.
Abstract: Moraxella catarrhalis is an exclusively human pathogen and is a common cause of otitis media in infants and children, causing 15%-20% of acute otitis media episodes. M. catarrhalis causes an estimated 2-4 million exacerbations of chronic obstructive pulmonary disease in adults annually in the United States. M. catarrhalis resembles commensal Neisseria species in culture and, thus, may be overlooked in samples from the human respiratory tract. The prevalence of colonization of the upper respiratory tract is high in infants and children but decreases substantially in adulthood. Most strains produce beta-lactamase and are thus resistant to ampicillin but susceptible to several classes of oral antimicrobial agents. Recent work has elucidated mechanisms of pathogenesis and focused on vaccine development to prevent otitis media in children and respiratory tract infections caused by M. catarrhalis in adults with chronic obstructive pulmonary disease.

Journal ArticleDOI
TL;DR: In this article, a series of tests were conducted to investigate the blast resistances of slabs constructed with both plain ultra-high performance fiber concrete (UHPFC) and reinforced UHPFC, and slabs reinforced with externally bonded (EB) fibre reinforced polymer (FRP) plates.

Book
01 Jan 2009
TL;DR: The formation and evolution of planetary crusts has been studied in detail in this paper, where a primary crust, the highland crust of the Moon, and a secondary crust, called the lunar maria, are discussed.
Abstract: Preface Acknowledgements List of abbreviations Prologue Notes and references 1. The planets: their formation and differentiation 2. A primary crust: the highland crust of the Moon 3. A secondary crust: the lunar maria 4. Mercury 5. Mars: early differentiation and planetary composition 6. Mars: crustal composition and evolution 7. Venus: a twin planet to Earth? 8. The oceanic crust of the Earth 9. The Hadean crust of the Earth 10. The Archean crust of the Earth 11. The post-Archean continental crust 12. Composition and evolution of the continental crust 13. Crusts on minor bodies 14. Reflections: the elusive patterns of planetary crusts Indexes.

Journal ArticleDOI
TL;DR: In this paper, the influence of leaders on organizational learning is discussed, and Limitations of some well known leadership theories for explaining this influence are described, and ideas for developing more comprehensive and accurate theories are suggested.
Abstract: This essay conveys some of the author's ideas about the influence of leaders on organizational learning. Limitations of some well known leadership theories for explaining this influence are described, and ideas for developing more comprehensive and accurate theories are suggested. Examples of specific ways leaders can influence organizational learning are provided. The methods used for most of the research on the subject are evaluated, and some alternative methods are suggested.

Journal ArticleDOI
TL;DR: Darusentan provides additional reduction in blood pressure in patients who have not attained their treatment goals with three or more antihypertensive drugs, and helps with fluid management with effective diuretic therapy.

Journal ArticleDOI
TL;DR: This "tutorial style" review outlines the theoretical foundation for computations of chiroptical properties for optically active molecules and highlights the strengths and weaknesses of currently popular time-dependent density functional methods.