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Institution

State University of New York System

EducationAlbany, New York, United States
About: State University of New York System is a education organization based out in Albany, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 54077 authors who have published 78070 publications receiving 2985160 citations.
Topics: Population, Poison control, RNA, Gene, Receptor


Papers
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Journal ArticleDOI
TL;DR: Endothelium-dependent relaxation of blood vessels is produced by a large number of agents (e.g., acetylcholine, ATP and ADP, substance P, bradykinin, histamine, thrombin, serotonin). With some agents, relaxation may be limited to certain species and/or blood vessels as mentioned in this paper.
Abstract: Endothelium-dependent relaxation of blood vessels is produced by a large number of agents (e.g., acetylcholine, ATP and ADP, substance P, bradykinin, histamine, thrombin, serotonin). With some agents, relaxation may be limited to certain species and/or blood vessels. Relaxation results from release of a very labile non-prostanoid endothelium-derived relaxing factor (EDRF) or factors. EDRF stimulates guanylate cyclase of the vascular smooth muscle, with the resulting increase in cyclic GMP activating relaxation. EDRF is rapidly inactivated by hemoglobin and superoxide. There is strong evidence that EDRF from many blood vessels and from cultured endothelial cells is nitric oxide (NO) and that its precursor is L-arginine. There is evidence for other relaxing factors, including an endothelium-derived hyperpolarizing factor in some vessels. Flow-induced shear stress also stimulates EDRF release. Endothelium-dependent relaxation occurs in resistance vessels as well as in larger arteries, and is generally more pronounced in arteries than veins. EDRF also inhibits platelet aggregation and adhesion to the blood vessel wall. Endothelium-derived contracting factors appear to be responsible for endothelium-dependent contractions produced by arachidonic acid and hypoxia in isolated systemic vessels and by certain agents and by rapid stretch in isolated cerebral vessels. In all such experiments, the endothelium-derived contracting factor appears to be some product or by-product of cyclooxygenase activity. Recently, endothelial cells in culture have been found to synthesize a peptide, endothelin, which is an extremely potent vasoconstrictor. The possible physiological roles and pathophysiological significance of endothelium-derived relaxing and contracting factors are briefly discussed.

1,868 citations

Journal ArticleDOI
D. S. Akerib1, S. Alsum2, Henrique Araujo3, X. Bai4, A. J. Bailey3, J. Balajthy5, P. Beltrame, Ethan Bernard6, A. Bernstein7, T. P. Biesiadzinski1, E. M. Boulton6, R. Bramante1, P. Brás8, D. Byram9, Sidney Cahn10, M. C. Carmona-Benitez11, C. Chan12, A.A. Chiller9, C. Chiller9, A. Currie3, J. E. Cutter13, T. J. R. Davison, A. Dobi14, J. E. Y. Dobson15, E. Druszkiewicz16, B. N. Edwards10, C. H. Faham14, S. Fiorucci12, R. J. Gaitskell12, V. M. Gehman14, C. Ghag15, K.R. Gibson1, M. G. D. Gilchriese14, C. R. Hall5, M. Hanhardt4, S. J. Haselschwardt11, S. A. Hertel6, D. P. Hogan6, M. Horn6, D. Q. Huang12, C. M. Ignarra17, M. Ihm6, R.G. Jacobsen6, W. Ji1, K. Kamdin6, K. Kazkaz7, D. Khaitan16, R. Knoche5, N.A. Larsen10, C. Lee1, B. G. Lenardo7, K. T. Lesko14, A. Lindote8, M.I. Lopes8, A. Manalaysay13, R. L. Mannino18, M. F. Marzioni, Daniel McKinsey6, D. M. Mei9, J. Mock19, M. Moongweluwan16, J. A. Morad13, A. St. J. Murphy20, C. Nehrkorn11, H. N. Nelson11, F. Neves8, K. O’Sullivan6, K. C. Oliver-Mallory6, K. J. Palladino17, E. K. Pease6, P. Phelps1, L. Reichhart15, C. Rhyne12, S. Shaw15, T. A. Shutt1, C. Silva8, M. Solmaz11, V. N. Solovov8, P. Sorensen14, S. Stephenson13, T. J. Sumner3, Matthew Szydagis19, D. J. Taylor, W. C. Taylor12, B. P. Tennyson10, P. A. Terman18, D. R. Tiedt4, W. H. To1, Mani Tripathi13, L. Tvrznikova6, S. Uvarov13, J.R. Verbus12, R. C. Webb18, J. T. White18, T. J. Whitis1, M. S. Witherell14, F.L.H. Wolfs16, Jilei Xu7, K. Yazdani3, Sarah Young19, Chao Zhang9 
TL;DR: This search yields no evidence of WIMP nuclear recoils and constraints on spin-independent weakly interacting massive particle (WIMP)-nucleon scattering using a 3.35×10^{4} kg day exposure of the Large Underground Xenon experiment are reported.
Abstract: We report constraints on spin-independent weakly interacting massive particle (WIMP)-nucleon scattering using a 3.35×10^{4} kg day exposure of the Large Underground Xenon (LUX) experiment. A dual-phase xenon time projection chamber with 250 kg of active mass is operated at the Sanford Underground Research Facility under Lead, South Dakota (USA). With roughly fourfold improvement in sensitivity for high WIMP masses relative to our previous results, this search yields no evidence of WIMP nuclear recoils. At a WIMP mass of 50 GeV c^{-2}, WIMP-nucleon spin-independent cross sections above 2.2×10^{-46} cm^{2} are excluded at the 90% confidence level. When combined with the previously reported LUX exposure, this exclusion strengthens to 1.1×10^{-46} cm^{2} at 50 GeV c^{-2}.

1,844 citations

Journal ArticleDOI
24 Jan 2008-Nature
TL;DR: Several facets of these kinds of C–H functionalization reactions are discussed and a perspective on how this methodology has affected the synthesis of complex natural products and potential pharmaceutical agents are provided.
Abstract: Novel reactions that can selectively functionalize carbon-hydrogen bonds are of intense interest to the chemical community because they offer new strategic approaches for synthesis. A very promising 'carbon-hydrogen functionalization' method involves the insertion of metal carbenes and nitrenes into C-H bonds. This area has experienced considerable growth in the past decade, particularly in the area of enantioselective intermolecular reactions. Here we discuss several facets of these kinds of C-H functionalization reactions and provide a perspective on how this methodology has affected the synthesis of complex natural products and potential pharmaceutical agents.

1,843 citations

Journal ArticleDOI
TL;DR: Some of the new anatomical, physiological and behavioral findings that have contributed to a reappraisal of function concerning the basal ganglia and cerebellar loops with the cerebral cortex are reviewed.

1,824 citations

Journal ArticleDOI
TL;DR: This paper argues that the total impact of an invader includes three fundamental dimensions: range, abundance, and the per-capita or per-biomass effect of the invader, and recommends previous approaches to measuring impact at different organizational levels, and suggests some new approaches.
Abstract: Although ecologists commonly talk about the impacts of nonindigenous species, little formal attention has been given to defining what we mean by impact, or connecting ecological theory with particular measures of impact. The resulting lack of generalizations regarding invasion impacts is more than an academic problem; we need to be able to distinguish invaders with minor effects from those with large effects in order to prioritize management efforts. This paper focuses on defining, evaluating, and comparing a variety of measures of impact drawn from empirical examples and theoretical reasoning. We begin by arguing that the total impact of an invader includes three fundamental dimensions: range, abundance, and the per-capita or per-biomass effect of the invader. Then we summarize previous approaches to measuring impact at different organizational levels, and suggest some new approaches. Reviewing mathematical models of impact, we argue that theoretical studies using community assembly models could act as a basis for better empirical studies and monitoring programs, as well as provide a clearer understanding of the relationship among different types of impact. We then discuss some of the particular challenges that come from the need to prioritize invasive species in a management or policy context. We end with recommendations about how the field of invasion biology might proceed in order to build a general framework for understanding and predicting impacts. In particular, we advocate studies designed to explore the correlations among different measures: Are the results of complex multivariate methods adequately captured by simple composite metrics such as species richness? How well are impacts on native populations correlated with impacts on ecosystem functions? Are there useful bioindicators for invasion impacts? To what extent does the impact of an invasive species depend on the system in which it is measured? Three approaches would provide new insights in this line of inquiry: (1) studies that measure impacts at multiple scales and multiple levels of organization, (2) studies that synthesize currently available data on different response variables, and (3) models designed to guide empirical work and explore generalities.

1,821 citations


Authors

Showing all 54162 results

NameH-indexPapersCitations
Meir J. Stampfer2771414283776
Bert Vogelstein247757332094
Zhong Lin Wang2452529259003
Peter Libby211932182724
Robert M. Califf1961561167961
Stephen V. Faraone1881427140298
David L. Kaplan1771944146082
David Baker1731226109377
Nora D. Volkow165958107463
David R. Holmes1611624114187
Richard J. Davidson15660291414
Ronald G. Crystal15599086680
Jovan Milosevic1521433106802
James J. Collins15166989476
Mark A. Rubin14569995640
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202325
2022168
20212,825
20202,891
20192,528
20182,456