Institution
State University of New York System
Education•Albany, New York, United States•
About: State University of New York System is a education organization based out in Albany, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 54077 authors who have published 78070 publications receiving 2985160 citations.
Topics: Population, Poison control, RNA, Gene, Receptor
Papers published on a yearly basis
Papers
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TL;DR: In this paper, sediment accumulation in the Yellow Sea epicontinental-shelf environment was investigated on 100-yr and 1000-yr time scales using 210Pb and 14C geochronologies.
386 citations
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TL;DR: In this paper, the doped Fe content in zeolitic imidazolate framework (ZIF)-8 precursors and achieved complete atomic dispersion of FeN4 sites, the sole Fe species in the catalyst based on Mosbauer spectroscopy data.
Abstract: Platinum group metal-free (PGM-free) catalysts for the oxygen reduction reaction (ORR) with atomically dispersed FeN4 sites have emerged as a potential replacement for low-PGM catalysts in acidic polymer electrolyte fuel cells (PEFCs). In this work, we carefully tuned the doped Fe content in zeolitic imidazolate framework (ZIF)-8 precursors and achieved complete atomic dispersion of FeN4 sites, the sole Fe species in the catalyst based on Mosbauer spectroscopy data. The Fe–N–C catalyst with the highest density of active sites achieved respectable ORR activity in rotating disk electrode (RDE) testing with a half-wave potential (E1/2) of 0.88 ± 0.01 V vs. the reversible hydrogen electrode (RHE) in 0.5 M H2SO4 electrolyte. The activity degradation was found to be more significant when holding the potential at 0.85 V relative to standard potential cycling (0.6–1.0 V) in O2 saturated acid electrolyte. The post-mortem electron microscopy analysis provides insights into possible catalyst degradation mechanisms associated with Fe–N coordination cleavage and carbon corrosion. High ORR activity was confirmed in fuel cell testing, which also divulged the promising performance of the catalysts at practical PEFC voltages. We conclude that the key factor behind the high ORR activity of the Fe–N–C catalyst is the optimum Fe content in the ZIF-8 precursor. While too little Fe in the precursors results in an insufficient density of FeN4 sites, too much Fe leads to the formation of clusters and an ensuing significant loss in catalytic activity due to the loss of atomically dispersed Fe to inactive clusters or even nanoparticles. Advanced electron microscopy was used to obtain insights into the clustering of Fe atoms as a function of the doped Fe content. The Fe content in the precursor also affects other key catalyst properties such as the particle size, porosity, nitrogen-doping level, and carbon microstructure. Thanks to using model catalysts exclusively containing FeN4 sites, it was possible to directly correlate the ORR activity with the density of FeN4 species in the catalyst.
385 citations
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TL;DR: Results indicate that while some cytoplasmic K+ channel beta subunits affect the inactivation kinetics of alpha subunits, a more general, and perhaps more fundamental, role is to mediate the biosynthetic maturation and surface expression of voltage-gated K+Channel complexes.
384 citations
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TL;DR: Lifestyle interventions for pediatric overweight are efficacious in the short term with some evidence for extended persistence and future research is required to identify moderators and mediators and to determine the optimal length and intensity of treatment required to produce enduring changes in weight status.
Abstract: Identifying and evaluating efficacious treatments for pediatric weight loss is of critical importance. This quantitative review represents the first meta-analysis of the efficacy of randomized controlled trials comparing lifestyle interventions to control conditions. MEDLINE, PsychINFO, and Cochrane Controlled Trials Register were searched up to August 2005. Eligible studies were randomized controlled trials involving lifestyle interventions for pediatric overweight that had as a comparison either a no-treatment or information/education-only control. The primary outcome of interest was change in weight status. Fourteen trials were eligible, resulting in 19 effect sizes. Information on study design, participant characteristics, interventions, and results were extracted using a standardized coding protocol. For trials with no-treatment controls, the mean effect size was 0.75 at end of treatment and 0.60 at follow-up. For trials with information/education only controls, the mean effect size was 0.48 at end of treatment and 0.91 at follow-up. No significant moderator effects were identified. Overall, lifestyle interventions for the treatment of pediatric overweight are efficacious in the short-term with some evidence for persistence of effects. Future research is required to identify moderators and mediators of outcome and to determine the optimal length and intensity of treatment required to produce enduring changes in weight status.
384 citations
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TL;DR: The benefits, obstacles, and challenges that can hinder (and have hindered) implementation of routine outcome monitoring in clinical practice are reviewed.
Abstract: This article reviews the benefits, obstacles, and challenges that can hinder (and have hindered) implementation of routine outcome monitoring in clinical practice. Recommendations for future routine outcome assessment efforts are also provided. Spanning three generations, as well as multiple developed tools and approaches, the four authors of this article have spent much of their careers working to address these issues and attempt to consolidate this learning and experience briefly here. Potential "elephants in the room" are brought into the discussion wherever relevant, rather than leaving them to obstruct silently the field's efforts. Some of these topics have been largely ignored, yet must be addressed if we are to fulfill our promise of integrating science and practice. This article is an attempt to identify these important issues and start an honest and open dialogue.
384 citations
Authors
Showing all 54162 results
Name | H-index | Papers | Citations |
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Meir J. Stampfer | 277 | 1414 | 283776 |
Bert Vogelstein | 247 | 757 | 332094 |
Zhong Lin Wang | 245 | 2529 | 259003 |
Peter Libby | 211 | 932 | 182724 |
Robert M. Califf | 196 | 1561 | 167961 |
Stephen V. Faraone | 188 | 1427 | 140298 |
David L. Kaplan | 177 | 1944 | 146082 |
David Baker | 173 | 1226 | 109377 |
Nora D. Volkow | 165 | 958 | 107463 |
David R. Holmes | 161 | 1624 | 114187 |
Richard J. Davidson | 156 | 602 | 91414 |
Ronald G. Crystal | 155 | 990 | 86680 |
Jovan Milosevic | 152 | 1433 | 106802 |
James J. Collins | 151 | 669 | 89476 |
Mark A. Rubin | 145 | 699 | 95640 |