Institution
State University of New York System
Education•Albany, New York, United States•
About: State University of New York System is a education organization based out in Albany, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 54077 authors who have published 78070 publications receiving 2985160 citations.
Topics: Population, Poison control, RNA, Gene, Receptor
Papers published on a yearly basis
Papers
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TL;DR: This study presents a new method that employs a convolutional neural network for detecting presence of invasive tumor on whole slide images that involves training the classifier on nearly 400 exemplars from multiple different sites, and scanners, and then independently validating on almost 200 cases from The Cancer Genome Atlas.
Abstract: With the increasing ability to routinely and rapidly digitize whole slide images with slide scanners, there has been interest in developing computerized image analysis algorithms for automated detection of disease extent from digital pathology images. The manual identification of presence and extent of breast cancer by a pathologist is critical for patient management for tumor staging and assessing treatment response. However, this process is tedious and subject to inter- and intra-reader variability. For computerized methods to be useful as decision support tools, they need to be resilient to data acquired from different sources, different staining and cutting protocols and different scanners. The objective of this study was to evaluate the accuracy and robustness of a deep learning-based method to automatically identify the extent of invasive tumor on digitized images. Here, we present a new method that employs a convolutional neural network for detecting presence of invasive tumor on whole slide images. Our approach involves training the classifier on nearly 400 exemplars from multiple different sites, and scanners, and then independently validating on almost 200 cases from The Cancer Genome Atlas. Our approach yielded a Dice coefficient of 75.86%, a positive predictive value of 71.62% and a negative predictive value of 96.77% in terms of pixel-by-pixel evaluation compared to manually annotated regions of invasive ductal carcinoma.
380 citations
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TL;DR: The authors examined organizational characteristics such as ideology, size, age, state sponsorship, alliance connections, and control of territory while controlling for factors that may also influence lethality, including the political system and relative wealth of the country in which the organization is based.
Abstract: Why are some terrorist organizations so much more deadly then others? This article examines organizational characteristics such as ideology, size, age, state sponsorship, alliance connections, and control of territory while controlling for factors that may also influence lethality, including the political system and relative wealth of the country in which the organization is based. Using data from the Memorial Institute for the Prevention of Terrorism's Terrorism Knowledge Base (TKB), we use a negative binomial model of organizational lethality, finding that organizational size, ideology, territorial control, and connectedness are important predictors of lethality while state sponsorship, organizational age, and host country characteristics are not.
380 citations
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TL;DR: A new set of luminescent platinum(II) diimine complexes has been synthesized and characterized, showing good Stern-Volmer behavior using 10-methylphenothiazine and N,N,N',N'-tetramethylbenzidine as reductive quenchers.
Abstract: A new set of luminescent platinum(II) diimine complexes has been synthesized and characterized. The anionic ligands in these complexes are arylacetylides. The complexes are brightly emissive in fluid solution with relative emission quantum yields phiem ranging from 3 x 10(-3) to 10(-1). Two series of complexes have been investigated. The first has the formula Pt(Rphen)(C...CC6H5)2 where Rphen is 1,10-phenanthroline substituted in the 5-position with R = H, Me, Cl, Br, NO2, or C...CC6H5, while the second has the formula Pt(dbbpy)(C=CC6H4X)2 where dbbpy = 4,4'-di(tert-butyl)bipyridine and X = H, Me, F, or NO2. From NMR, IR, and electronic spectroscopies, all of the complexes are assigned a square planar coordination geometry with cis-alkynyl ligands. The crystal structure of Pt(phen)(Ce-CC6H4CH3)2 confirms this assignment. All of the complexes exhibit an absorption band at ca. 400 nm that corresponds to a Pt d-->pi*diimine charge-transfer transition. The variation of lambdamax for this band with substituent variation supports this assignment. From similar changes in the energy of the solution luminescence as a function of substituents R and X, the emissive excited state is also of MLCT origin, but with spin-forbidden character on the basis of excited-state lifetime measurements (0.01-5.6 micros). The complexes undergo electron-transfer quenching, showing good Stern-Volmer behavior using 10-methylphenothiazine and N,N,N',N'-tetramethylbenzidine as reductive quenchers. Excited-state reduction potentials are estimated on the basis of a simple thermochemical analysis. Crystal data for Pt(phen)(C...CC6H4CH3)2: monoclinic, space group C2/c, a = 19.0961(1) A, b = 10.4498(1) A, c = 11.8124(2) A, beta = 108.413(1) degrees, V = 2236.49 A3, number of reflections 1614, number of variables 150, R1 = 0.0163, wR2 (I > 2sigma) = 0.0410.
380 citations
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TL;DR: In this article, it was shown that in natural sediments Mn-oxides can completely oxidize solid phase sulfides to SO4− under anoxic conditions and that the reaction is inhibited by DNP (dinitrophenol) and azide, implying biological mediation by a group of chemolithotrophic bacteria.
379 citations
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TL;DR: In this paper, a modified zero-crossing method using curve fitting of voltage samples is proposed, and polynomial fitting of the discrete Fourier transform (DFT) quasi-stationary phasor data for calculation of the rate of change of the positive sequence phase angle.
Abstract: Three new techniques for frequency measurement are proposed. The first is a modified zero-crossing method using curve fitting of voltage samples. The second method is based on polynomial fitting of the discrete Fourier transform (DFT) quasi-stationary phasor data for calculation of the rate of change of the positive sequence phase angle. The third method operates on a complex signal obtained by the standard technique of quadrature demodulation. All three methods are characterized by immunity to reasonable amounts of noise and harmonics in power systems. The performance of the proposed techniques is illustrated for several scenarios by computer simulation. >
379 citations
Authors
Showing all 54162 results
Name | H-index | Papers | Citations |
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Meir J. Stampfer | 277 | 1414 | 283776 |
Bert Vogelstein | 247 | 757 | 332094 |
Zhong Lin Wang | 245 | 2529 | 259003 |
Peter Libby | 211 | 932 | 182724 |
Robert M. Califf | 196 | 1561 | 167961 |
Stephen V. Faraone | 188 | 1427 | 140298 |
David L. Kaplan | 177 | 1944 | 146082 |
David Baker | 173 | 1226 | 109377 |
Nora D. Volkow | 165 | 958 | 107463 |
David R. Holmes | 161 | 1624 | 114187 |
Richard J. Davidson | 156 | 602 | 91414 |
Ronald G. Crystal | 155 | 990 | 86680 |
Jovan Milosevic | 152 | 1433 | 106802 |
James J. Collins | 151 | 669 | 89476 |
Mark A. Rubin | 145 | 699 | 95640 |