State University of New York System

About: State University of New York System is a education organization based out in Albany, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 54077 authors who have published 78070 publications receiving 2985160 citations.

A Mathematical Representation of Near-Fault Ground Motions

Abstract: A simple, yet effective, analytical model is proposed for the representation of near-field strong ground motions. The model adequately describes the impulsive character of near-fault ground motions both qualitatively and quantitatively. In addition, it can be used to analytically reproduce empirical observations that are based on available near-source records. The input parameters of the model have an unambiguous physical meaning. The proposed analytical model has been calibrated using a large number of actual near-field ground-motion records. It successfully simulates the entire set of available near-fault displacement, velocity, and (in many cases) acceleration time histories, as well as the corresponding deformation, velocity, and acceleration response spectra. Furthermore, a very simplified methodology for generating realistic synthetic ground motions that are adequate for engineering analysis and design is outlined and applied. Finally, it should be noted that the analytical model (along with the scaling laws of its parameters) proposed in the present work has the potential to facilitate the study of the elastic and inelastic response of conventional, nonconventional (e.g., base-isolated), and special structures (e.g., suspension bridges, fluid-storage tanks) subjected to near-source seismic excitations as a function of the model input parameters and thus, ultimately, as a function of earthquake size.

Molecular mechanisms of translation initiation in eukaryotes.

Abstract: Translation initiation is a complex process in which initiator tRNA, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the initiation codon of mRNA. The cap-binding complex eIF4F and the factors eIF4A and eIF4B are required for binding of 43S complexes (comprising a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5′ end of capped mRNA but are not sufficient to promote ribosomal scanning to the initiation codon. eIF1A enhances the ability of eIF1 to dissociate aberrantly assembled complexes from mRNA, and these factors synergistically mediate 48S complex assembly at the initiation codon. Joining of 48S complexes to 60S subunits to form 80S ribosomes requires eIF5B, which has an essential ribosome-dependent GTPase activity and hydrolysis of eIF2-bound GTP induced by eIF5. Initiation on a few mRNAs is cap-independent and occurs instead by internal ribosomal entry. Encephalomyocarditis virus (EMCV) and hepatitis C virus epitomize distinct mechanisms of internal ribosomal entry site (IRES)-mediated initiation. The eIF4A and eIF4G subunits of eIF4F bind immediately upstream of the EMCV initiation codon and promote binding of 43S complexes. EMCV initiation does not involve scanning and does not require eIF1, eIF1A, and the eIF4E subunit of eIF4F. Initiation on some EMCV-like IRESs requires additional noncanonical initiation factors, which alter IRES conformation and promote binding of eIF4A/4G. Initiation on the hepatitis C virus IRES is even simpler: 43S complexes containing only eIF2 and eIF3 bind directly to the initiation codon as a result of specific interaction of the IRES and the 40S subunit.

On Fuzzy Mapping and Control

Abstract: A fuzzy mapping from X to Y is a fuzzy set on X × Y. The concept is extended to fuzzy mappings of fuzzy sets on X to Y, fuzzy function and its inverse, fuzzy parametric functions, fuzzy observation, and control. Set theoretical relations are obtained for fuzzy mappings, fuzzy functions, and fuzzy parametric functions. It is shown that under certain conditions a precise control goal can be attained with fuzzy observation and control as long as the observations become sufficiently precise when the goal is approached.